{"id":2912,"date":"2008-11-18T19:54:57","date_gmt":"2008-11-19T00:54:57","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/"},"modified":"2018-07-05T15:27:54","modified_gmt":"2018-07-05T19:27:54","slug":"11-17-08-snider-lab-publishes-article-in-pnas","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/","title":{"rendered":"11\/17\/08: Snider lab publishes article in PNAS"},"content":{"rendered":"<p>&nbsp;<\/p>\n<div style=\"margin: 0in 0in 0pt; text-indent: 0.5in;\" align=\"left\">\n<p>A large multi-institutional collaboration, including Dr. William Snider\u2019s laboratory, published an article in the Proceedings of the National Academy of Science which identifies a critical component in the development of human syndromes involving craniofacial and cardiac defects.\u00a0This work began by characterizing patients with craniofacial and cardiac abnormalities akin to those seen in DiGeorge\/Velocardiofacial Syndrome.\u00a0Interestingly, these patients possess a unique deletion encompassing roughly 11 genes, including the ERK2 gene, a key element of the MAP kinase intracellular signaling pathway.\u00a0The research shows that these patients exhibit reduced expression of ERK2.<\/p>\n<p>A transient, pluripotent cell population known as neural crest contributes to the development of the craniofacial and cardiac structures disrupted in these patients and those with DiGeorge syndrome.\u00a0Thus, the authors generated mice with deletions of ERK2 and other components of the MAP Kinase pathway, specifically in neural crest.\u00a0Remarkably, these animals have defects in craniofacial and cardiac development comparable to those seen in the patients.\u00a0Further work demonstrates that all elements of the MAP kinase cascade, including a downstream transcription factor, SRF, are absolutely necessary for the appropriate development of neural crest derived structures.<\/p>\n<p>Overall, the evidence suggests that of the 11 genes deleted in these patients, ERK2 is most critical.\u00a0These data provide the first direct evidence for an essential role for MAP kinase signaling in neural crest development in mouse and humans.\u00a0This work further argues that MAP kinase signaling is part of a common pathway disrupted in other human syndromes involving certain types of craniofacial and cardiac defects.\u00a0Correcting aberrations in MAPK signaling may represent an interesting therapeutic possibility for future study.<\/p>\n<p>Full Article: <a href=\"http:\/\/www.pnas.org\/content\/105\/44\/17115.full.pdf+html\" target=\"_blank\" rel=\"noopener\">http:\/\/www.pnas.org\/content\/105\/44\/17115.full.pdf+html<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; A large multi-institutional collaboration, including Dr. William Snider\u2019s laboratory, published an article in the Proceedings of the National Academy of Science which identifies a critical component in the development of human syndromes involving craniofacial and cardiac defects.\u00a0This work began by characterizing patients with craniofacial and cardiac abnormalities akin to those seen in DiGeorge\/Velocardiofacial Syndrome.\u00a0Interestingly, &hellip; <a href=\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\" aria-label=\"Read more about 11\/17\/08: Snider lab publishes article in PNAS\">Read more<\/a><\/p>\n","protected":false},"author":5952,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2912","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>11\/17\/08: Snider lab publishes article in PNAS | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"11\/17\/08: Snider lab publishes article in PNAS | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"&nbsp; A large multi-institutional collaboration, including Dr. William Snider\u2019s laboratory, published an article in the Proceedings of the National Academy of Science which identifies a critical component in the development of human syndromes involving craniofacial and cardiac defects.\u00a0This work began by characterizing patients with craniofacial and cardiac abnormalities akin to those seen in DiGeorge\/Velocardiofacial Syndrome.\u00a0Interestingly, &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:published_time\" content=\"2008-11-19T00:54:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-07-05T19:27:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:site\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"11\/17\/08: Snider lab publishes article in PNAS\",\"datePublished\":\"2008-11-19T00:54:57+00:00\",\"dateModified\":\"2018-07-05T19:27:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\"},\"wordCount\":284,\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\",\"name\":\"11\/17\/08: Snider lab publishes article in PNAS | UNC Neuroscience Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\"},\"datePublished\":\"2008-11-19T00:54:57+00:00\",\"dateModified\":\"2018-07-05T19:27:54+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"11\/17\/08: Snider lab publishes article in PNAS\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/\",\"name\":\"UNC Neuroscience Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/author\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"11\/17\/08: Snider lab publishes article in PNAS | UNC Neuroscience Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/","og_locale":"en_US","og_type":"article","og_title":"11\/17\/08: Snider lab publishes article in PNAS | UNC Neuroscience Center","og_description":"&nbsp; A large multi-institutional collaboration, including Dr. William Snider\u2019s laboratory, published an article in the Proceedings of the National Academy of Science which identifies a critical component in the development of human syndromes involving craniofacial and cardiac defects.\u00a0This work began by characterizing patients with craniofacial and cardiac abnormalities akin to those seen in DiGeorge\/Velocardiofacial Syndrome.\u00a0Interestingly, &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/","og_site_name":"UNC Neuroscience Center","article_published_time":"2008-11-19T00:54:57+00:00","article_modified_time":"2018-07-05T19:27:54+00:00","twitter_card":"summary_large_image","twitter_creator":"@uncneuro","twitter_site":"@uncneuro","twitter_misc":{"Written by":"","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/"},"author":{"name":"","@id":""},"headline":"11\/17\/08: Snider lab publishes article in PNAS","datePublished":"2008-11-19T00:54:57+00:00","dateModified":"2018-07-05T19:27:54+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/"},"wordCount":284,"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/","url":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/","name":"11\/17\/08: Snider lab publishes article in PNAS | UNC Neuroscience Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website"},"datePublished":"2008-11-19T00:54:57+00:00","dateModified":"2018-07-05T19:27:54+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neuroscience\/11-17-08-snider-lab-publishes-article-in-pnas\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neuroscience\/"},{"@type":"ListItem","position":2,"name":"11\/17\/08: Snider lab publishes article in PNAS"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website","url":"https:\/\/www.med.unc.edu\/neuroscience\/","name":"UNC Neuroscience Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"","url":"https:\/\/www.med.unc.edu\/neuroscience\/author\/"}]}},"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/neuroscience\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/users\/5952"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=2912"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2912\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=2912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=2912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=2912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}