{"id":2930,"date":"2012-04-19T18:20:00","date_gmt":"2012-04-19T22:20:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/4-19-12-unc-neuroscientists-awarded-2-million-to-study-roots-of-cognitive-disabilities\/"},"modified":"2018-07-05T15:05:19","modified_gmt":"2018-07-05T19:05:19","slug":"4-19-12-unc-neuroscientists-awarded-2-million-to-study-roots-of-cognitive-disabilities","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/4-19-12-unc-neuroscientists-awarded-2-million-to-study-roots-of-cognitive-disabilities\/","title":{"rendered":"4\/19\/12: UNC neuroscientists awarded $2 million to study roots of cognitive disabilities"},"content":{"rendered":"
\n

<\/p>\n

UNC researchers will attempt to understand the cognitive disabilities in patients with RAS\/MARK syndromes.<\/p>\n

\n
\"image2\"
William Snider, MD<\/figcaption><\/figure>\n<\/div>\n

Thursday, April 19, 2012<\/p>\n

CHAPEL HILL, N.C. \u2013 In the developing fetus, a number of genes encode the components of a powerful intracellular signaling pathway known as ERK\/MAPK. Mutations in these genes have been shown to cause neurodevelopmental delays, cardiac and craniofacial abnormalities, and autism-related disorders.<\/p>\n

Collectively, these disorders are known as \u201cRasopathies,\u201d or \u201cRAS\/MAPK syndromes,\u201d a term that incorporates the signaling pathway, RAS, that regulates the expression of autism-linked genes.<\/p>\n

With a new 5-year grant totaling roughly $2 million from the National Institutes of Health, researchers at the University of North Carolina at Chapel Hill Neuroscience Center<\/a> (UNC-NC) will attempt to understand the cognitive disabilities in patients with these syndromes. Co-investigators in this work are UNC-NC director William Snider, MD<\/a>, professor of neurology and cell and molecular physiology, and neuroscientist Benjamin Philpot, PhD<\/a>, associate professor of cell and molecular physiology.<\/p>\n

\u201cWe plan to disrupt this ERK\/MAPK pathway in specific cell types in the developing brains of mice,\u201d Snider says. \u201cWe will also generate a mouse model that allows reversal of ERK\/MAPK signaling abnormalities in postnatal animals. Ability to manipulate the pathway in postnatal life may enable the development of new treatment strategies.\u201d<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

UNC researchers will attempt to understand the cognitive disabilities in patients with RAS\/MARK syndromes.<\/p>\n","protected":false},"author":80868,"featured_media":2931,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2930","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\n4\/19\/12: UNC neuroscientists awarded $2 million to study roots of cognitive disabilities | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/4-19-12-unc-neuroscientists-awarded-2-million-to-study-roots-of-cognitive-disabilities\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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