{"id":2939,"date":"2009-05-26T16:00:00","date_gmt":"2009-05-26T20:00:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/5-26-09-philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome-1\/"},"modified":"2018-07-05T15:23:24","modified_gmt":"2018-07-05T19:23:24","slug":"5-26-09-philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome-1","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/5-26-09-philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome-1\/","title":{"rendered":"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome"},"content":{"rendered":"

 <\/p>\n

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In a paper published in this week’s issue of Nature Neuroscience researchers in Ben Philpot\u2019s lab have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome, an autism spectrum disorder. In a study published in the journal Nature Neuroscience, they found that the gene, UBE3A, is needed so that neurons in the brain can adjust their connections with other neurons for storing sensory information. They also made the exciting discovery that this brain plasticity could be restored in Angelman model mice by sensory deprivation. This finding suggests that this latent ability to express plasticity in Angelman syndrome patients might be tapped into through future pharmaceutical or behavioral treatments to restore lost cognitive functions.<\/p>\n

[Full paper]<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

  In a paper published in this week’s issue of Nature Neuroscience researchers in Ben Philpot\u2019s lab have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome, an autism spectrum disorder. In a study published in the journal Nature Neuroscience, they found that the … Read more<\/a><\/p>\n","protected":false},"author":80868,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2939","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"\nPhilpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/5-26-09-philpot-lab-reverses-plasticity-defects-in-a-mouse-model-of-the-mental-retardation-angelman-syndrome-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Philpot lab reverses plasticity defects in a mouse model of the mental retardation Angelman syndrome | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"  In a paper published in this week’s issue of Nature Neuroscience researchers in Ben Philpot\u2019s lab have discovered in mice how a single disrupted gene can cause a form of severe mental retardation known as Angelman syndrome, an autism spectrum disorder. 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