{"id":2976,"date":"2009-09-07T16:00:00","date_gmt":"2009-09-07T20:00:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/"},"modified":"2018-07-05T15:20:56","modified_gmt":"2018-07-05T19:20:56","slug":"9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/","title":{"rendered":"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation"},"content":{"rendered":"
\n
\n
\"image2\"
<\/figcaption><\/figure>\n<\/div>\n
\n

n the cover article<\/a> published in the September 4th issue of Cell, Franck Polleux\u2019s lab discovered that establishing the neural wiring necessary to function normally depends on the ability of neurons to make finger-like projections of their membrane called filopodia.<\/p>\n

In laying down the neural circuitry of the developing brain, billions of neurons must first migrate to their correct destinations and then form complex synaptic connections with their new neighbors.<\/p>\n

When the process goes awry, neurodevelopmental disorders such as mental retardation, dyslexia or autism may result. The Polleux lab discovered that establishing the neural wiring necessary to function normally depends on the ability of neurons to make finger-like projections of their membrane called filopodia. The finding indicates that the current notion regarding how cells change shape, migrate or differentiate need<\/p>\n

s to be revisited.<\/p>\n

Scientists have thought that the only way for a cell to morph and move is through the action of the cytoskeleton or the scaffold inside the cell, pushing membrane forward or sucking it in, said senior study investigator Franck Polleux, Ph.D., <\/a><\/span>Associate Professor at the UNC Neuroscience Center.<\/p>\n

But Polleux\u2019s study shows that the brain protein srGAP2 can also impose cell shape by directly bending membranes, forming filopodia as a mean to control the migration and branching of neurons during brain development.<\/p>\n

Interestingly, srGAP2 is one of a family of proteins that have been implicated in a severe mental retardation syndrome called the 3p- syndrome. Therefore this research could also yield important insights into the underlying causes of this and other forms of mental retardation.<\/p>\n

Polleux and his colleagues began looking at srGAP2 because the gene was almost exclusively \u201cturned on\u201d or expressed during brain development. The brain protein contains a unique combination of domains \u2013 small functional chunks of protein sequence that may be common to other proteins as well. The star of these domains is one called the F-BAR domain, one of a handful of similarly termed \u201cBAR domains\u201d that have recently become a hotbed of research.<\/p>\n

The UNC researchers were among the first to master a laboratory technique that enabled them to manipulate which genes are turned on or off in neurons, a notoriously difficult cell type.<\/p>\n

Working with slices of mouse brain, they used electrical current to intro<\/p>\n

duce pieces of genetic material that would either ramp up or, conversely, knock down the action of the protein\u2019s F-BAR domain. They then cultured brain slices in petri dishes allowing researchers to watch how the neurons behaved \u2019in the wild\u2019 in their native environment. When the researchers ramped up the activity of the domain, they saw that the neurons formed the finger-like filopodia which blocked migration by inducing too many branches.<\/p>\n

\u201cThe textbook notion is that F-BAR proteins fold inward, but here we show it can do the opposite\u201d said Polleux. \u201cThis is a completely novel mechanism for producing filopodia.\u201d<\/p>\n

The researchers then found that when they reduced the expression of this protein, the neurons migrated at a faster rate and branched less. Under a microscope, neurons move like little inchworms. In front, the long thin cellular protrusion of the neuron extends, pauses, then drags the bulbous cell body behind it, then extends again, and so on.<\/p>\n

Polleux says the F-BAR domain of srGAP2 appears to tightly control the amount of branching neurons undergo so they can be more streamlined when they need to migrate, and branch when they need to establish connections with other neurons.<\/p>\n

Because disruptions in these critical connections would have detrimental effects on brain development, Polleux will now collaborate with clinicians at UNC to determine whether mutations in the srGAP2 gene are involved in autism or in other forms of mental retardation in addition to the 3p- syndrome. His laboratory is also interested in determining the function of approximately 25 other genes containing F-BAR-like domains, many of which are expressed in the developing brain.<\/p>\n

Funding for the studies led at UNC came from the National Institutes of Health<\/a><\/span><\/span> and the Pew Charitable Trusts<\/a><\/span><\/span>. Study co-authors from UNC include Sabrice Guerrier, Ph.D., former graduate student; Jaeda Coutinho-Budd, graduate student; Takayuki Sassa, Ph.D., former postdoctoral fellow; Aur\u00e9lie Gresset, graduate student; and Nicole Vincent Jordan, graduate student.<\/p>\n

Video interview with Dr. Franck Polleux<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

n the cover article published in the September 4th issue of Cell, Franck Polleux\u2019s lab discovered that establishing the neural wiring necessary to function normally depends on the ability of neurons to make finger-like projections of their membrane called filopodia. In laying down the neural circuitry of the developing brain, billions of neurons must first … Read more<\/a><\/p>\n","protected":false},"author":80868,"featured_media":2977,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2976","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\n9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"n the cover article published in the September 4th issue of Cell, Franck Polleux\u2019s lab discovered that establishing the neural wiring necessary to function normally depends on the ability of neurons to make finger-like projections of their membrane called filopodia. In laying down the neural circuitry of the developing brain, billions of neurons must first … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:published_time\" content=\"2009-09-07T20:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-07-05T19:20:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"277\" \/>\n\t<meta property=\"og:image:height\" content=\"357\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Nathaniel Bailey\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:site\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nathaniel Bailey\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\"},\"author\":{\"name\":\"Nathaniel Bailey\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"headline\":\"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation\",\"datePublished\":\"2009-09-07T20:00:00+00:00\",\"dateModified\":\"2018-07-05T19:20:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\"},\"wordCount\":716,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\",\"name\":\"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation | UNC Neuroscience Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg\",\"datePublished\":\"2009-09-07T20:00:00+00:00\",\"dateModified\":\"2018-07-05T19:20:56+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg\",\"width\":277,\"height\":357},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/\",\"name\":\"UNC Neuroscience Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\",\"name\":\"Nathaniel Bailey\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g\",\"caption\":\"Nathaniel Bailey\"},\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/author\/nathaniel-bailey\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation | UNC Neuroscience Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/","og_locale":"en_US","og_type":"article","og_title":"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation | UNC Neuroscience Center","og_description":"n the cover article published in the September 4th issue of Cell, Franck Polleux\u2019s lab discovered that establishing the neural wiring necessary to function normally depends on the ability of neurons to make finger-like projections of their membrane called filopodia. In laying down the neural circuitry of the developing brain, billions of neurons must first … Read more","og_url":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/","og_site_name":"UNC Neuroscience Center","article_published_time":"2009-09-07T20:00:00+00:00","article_modified_time":"2018-07-05T19:20:56+00:00","og_image":[{"width":277,"height":357,"url":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","type":"image\/jpeg"}],"author":"Nathaniel Bailey","twitter_card":"summary_large_image","twitter_creator":"@uncneuro","twitter_site":"@uncneuro","twitter_misc":{"Written by":"Nathaniel Bailey","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/"},"author":{"name":"Nathaniel Bailey","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994"},"headline":"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation","datePublished":"2009-09-07T20:00:00+00:00","dateModified":"2018-07-05T19:20:56+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/"},"wordCount":716,"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/","url":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/","name":"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation | UNC Neuroscience Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","datePublished":"2009-09-07T20:00:00+00:00","dateModified":"2018-07-05T19:20:56+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#primaryimage","url":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","width":277,"height":357},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neuroscience\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neuroscience\/"},{"@type":"ListItem","position":2,"name":"9\/7\/09: Polleux lab identifies critical gene for brain development and mental retardation"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website","url":"https:\/\/www.med.unc.edu\/neuroscience\/","name":"UNC Neuroscience Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994","name":"Nathaniel Bailey","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g","caption":"Nathaniel Bailey"},"url":"https:\/\/www.med.unc.edu\/neuroscience\/author\/nathaniel-bailey\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2-233x300.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/9-7-09-polleux-lab-identifies-critical-gene-for-brain-development-and-mental-retardation-2-image2-150x150.jpeg","featured_image_alt":"","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/neuroscience\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/users\/80868"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=2976"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2976\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media\/2977"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=2976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=2976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=2976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}