{"id":2991,"date":"2012-06-04T19:05:00","date_gmt":"2012-06-04T23:05:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/"},"modified":"2018-07-05T15:04:19","modified_gmt":"2018-07-05T19:04:19","slug":"deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/","title":{"rendered":"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death"},"content":{"rendered":"
\n
\n
\"image2\"
<\/figcaption><\/figure>\n<\/div>\n

CHAPEL HILL, N.C. \u2013 Embryonic stem cells \u2014 those revered cells that give rise to every cell type in the body \u2014 just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study published online May 3, 2012 in the journal Molecular Cell<\/a>.<\/p>\n

The finding offers a new glimpse into the private lives of stem cells that could help scientists use them to grow new neurons or other cells to replace those that have been lost in patients with Parkinson\u2019s and other diseases. \u201cDespite the huge potential of stem cells for therapeutic use, very few people have actually investigated their basic biology,\u201d said study senior researcher Mohanish Deshmukh, PhD<\/a>, professor of cell and developmental biology at the University of North Carolina at Chapel Hill<\/a>. \u201cThese results could have significant implications from a therapeutic perspective.\u201d<\/p>\n

Of all the important things our bodies\u2019 cells do, staying alive is clearly key. But a cell\u2019s ability to die when something goes wrong is equally critical. For example, a faulty self-destruct button is one factor that allows cancer cells to proliferate unchecked and cause tumors.<\/p>\n

Deshmukh and his colleagues discovered stem cells are extremely sensitive to DNA damage, which can be caused by factors like chemicals, radiation or viruses. The experiment showed that virtually 100 percent of human embryonic stem cells treated with a DNA-damaging drug killed themselves within 5 hours, as compared to 24 hours for other types of cells. \u201cThat\u2019s an incredibly rapid rate of death,\u201d said Deshmukh, who also is a member of the UNC Neuroscience Center<\/a> and Lineberger Comprehensive Cancer Center.<\/a><\/p>\n

The hair-trigger suicidal response is an important adaptation for embryonic stem cells, said the UNC School of Medicine<\/a> researcher, because a slower response could allow DNA damage to proliferate and harm the embryo. \u201cMutations that develop in these cells could be catastrophic for the developing organism, so it would make sense for these cells to be rapidly eliminated.\u201d<\/p>\n

The key to the stem cells\u2019 quick response is that they pre-activate a critical protein called Bax, the researchers found. In most cells, Bax is is kept in an inactive form, waiting for a long chain of events to rouse it into action if the cell becomes damaged enough to kill itself. In human embryonic stem cells, the team found Bax standing at attention in its active form in the Golgi apparatus, a part of the cell that processes and modifies proteins.<\/p>\n

\u201cWhat these cells do is very clever,\u201d said Deshmukh. \u201cThey have activated Bax, but they\u2019ve also parked it in a safe little compartment\u2014the Golgi.\u201d If the cell detects DNA damage, Bax zips over to the mitochondrion (the cell\u2019s power plant), where it signals other proteins to shut the cell down.<\/p>\n

It\u2019s like starting a 100-yard race at the 80-yard line, said Deshmukh. You\u2019re guaranteed to get to the finish line first because you did most of the work before the race began. However, there are built-in safeguards against a hair trigger activation of death. Pre-activated Bax is housed in the Golgi keeping the protein from accidentally triggering cell death when it\u2019s not warranted.<\/p>\n

This extreme sensitivity to DNA damage lasts only a few days during early development. After the embryonic stem cells begin differentiating into early progenitors that give rise to specific cell types (like heart cells or skin cells), Bax reverts to its inactive state.<\/p>\n

UNC Co-first authors of this study are \u2013 Raluca Dumitru and Vivian Gama. Other UNC Co-authors include B. Matthew Fagan, Jacquelyn J Bower, Vijay Swahari and Larysa H Pevny. The study was funded by grants from the National Institutes of Health (National Institute of General Medical Sciences) and UNC\u2019s University Cancer Research Fund.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

CHAPEL HILL, N.C. \u2013 Embryonic stem cells \u2014 those revered cells that give rise to every cell type in the body \u2014 just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study … Read more<\/a><\/p>\n","protected":false},"author":80868,"featured_media":2992,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-2991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\n6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"CHAPEL HILL, N.C. \u2013 Embryonic stem cells \u2014 those revered cells that give rise to every cell type in the body \u2014 just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:published_time\" content=\"2012-06-04T23:05:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-07-05T19:04:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1271\" \/>\n\t<meta property=\"og:image:height\" content=\"843\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Nathaniel Bailey\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:site\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nathaniel Bailey\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\"},\"author\":{\"name\":\"Nathaniel Bailey\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"headline\":\"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death\",\"datePublished\":\"2012-06-04T23:05:00+00:00\",\"dateModified\":\"2018-07-05T19:04:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\"},\"wordCount\":646,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\",\"name\":\"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death | UNC Neuroscience Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg\",\"datePublished\":\"2012-06-04T23:05:00+00:00\",\"dateModified\":\"2018-07-05T19:04:19+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg\",\"width\":1271,\"height\":843},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/\",\"name\":\"UNC Neuroscience Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\",\"name\":\"Nathaniel Bailey\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g\",\"caption\":\"Nathaniel Bailey\"},\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/author\/nathaniel-bailey\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death | UNC Neuroscience Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/","og_locale":"en_US","og_type":"article","og_title":"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death | UNC Neuroscience Center","og_description":"CHAPEL HILL, N.C. \u2013 Embryonic stem cells \u2014 those revered cells that give rise to every cell type in the body \u2014 just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study … Read more","og_url":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/","og_site_name":"UNC Neuroscience Center","article_published_time":"2012-06-04T23:05:00+00:00","article_modified_time":"2018-07-05T19:04:19+00:00","og_image":[{"width":1271,"height":843,"url":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg","type":"image\/jpeg"}],"author":"Nathaniel Bailey","twitter_card":"summary_large_image","twitter_creator":"@uncneuro","twitter_site":"@uncneuro","twitter_misc":{"Written by":"Nathaniel Bailey","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/"},"author":{"name":"Nathaniel Bailey","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994"},"headline":"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death","datePublished":"2012-06-04T23:05:00+00:00","dateModified":"2018-07-05T19:04:19+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/"},"wordCount":646,"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/","url":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/","name":"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death | UNC Neuroscience Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg","datePublished":"2012-06-04T23:05:00+00:00","dateModified":"2018-07-05T19:04:19+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#primaryimage","url":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg","width":1271,"height":843},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neuroscience\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neuroscience\/"},{"@type":"ListItem","position":2,"name":"6\/4\/12: Deshmukh Lab Publishes in Molecular Cell about Stem Cells Primed for Rapid Death"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website","url":"https:\/\/www.med.unc.edu\/neuroscience\/","name":"UNC Neuroscience Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994","name":"Nathaniel Bailey","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g","caption":"Nathaniel Bailey"},"url":"https:\/\/www.med.unc.edu\/neuroscience\/author\/nathaniel-bailey\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2-300x199.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2-768x509.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2-1024x679.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/deshmukh-lab-publishes-in-molecular-cell-about-stem-cells-primed-for-rapid-death-image2-150x150.jpeg","featured_image_alt":"","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/neuroscience\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/users\/80868"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=2991"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/2991\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media\/2992"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=2991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=2991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=2991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}