{"id":3020,"date":"2012-11-19T20:20:00","date_gmt":"2012-11-20T01:20:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/"},"modified":"2018-07-05T14:58:23","modified_gmt":"2018-07-05T18:58:23","slug":"study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/","title":{"rendered":"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects"},"content":{"rendered":"

New research from UNC provides a neurological justification for this therapeutic approach, but researchers caution there could be unanticipated effects.<\/p>\n

\n
\n
\"Study
\nclick to enlarge<\/a>
\n In vivo voltammograms showing higher dopamine (DA) release in the nucleus accumbens (NAc) and lower release in the dorsal striatum of Angelman syndrome model mice (Ube3a m-\/p+) compared to wild-type mice (WT). <\/span> <\/span><\/div>\n
\"Study
\n click to enlarge<\/a>
\n Left to right: Benjamin D. Philpot, PhD, and C.J. Malanga, MD, PhD. <\/span> <\/span><\/div>\n
\n

Media contact:<\/b> Tom Hughes, 919-966-6047, tahughes@unch.unc.edu <\/a><\/p>\n

<\/b><\/span>Monday, Nov. 12, 2012<\/p>\n

CHAPEL HILL, N.C. \u2013 Last year a clinical trial of L-DOPA — a mainstay of Parkinson\u2019s disease therapy — was launched for Angelman syndrome, a rare intellectual disorder that shares similar motor symptoms such as tremors and difficulty with balance. The clinical trial is based on a 10-year-old case report showing benefit with the drug, but few studies since have explored the neurological justification for using L-DOPA to treat parkinsonian features in Angelman syndrome.<\/p>\n

New research from the University of North Carolina School of Medicine<\/a>, conducted in animal models of the disorder, now provides justification for this therapeutic approach. The study, published online ahead of print on Nov. 12 by the Journal of Clinical Investigation<\/a>, suggests that L-DOPA could compensate for a loss of the neurochemical dopamine in the brain\u2019s motor pathways and improve motor symptoms. However, it also indicates that the drug could add to an already increased amount of dopamine in the brain\u2019s reward pathways and thus have unanticipated consequences on emotion and attention.<\/p>\n

\u201cThe results were extremely surprising, because we don\u2019t know of any other disorder where dopamine is affected one way in one brain pathway and the opposite way in another,\u201d said Benjamin D. Philpot, PhD<\/a>, associate professor of cell biology and physiology at UNC.<\/p>\n

\u201cIf what we see in humans mirrors what we see in mice, then it does provide some optimism that L-DOPA might provide benefit for tremor,\u201d said C.J. Malanga, MD, PhD<\/a>, associate professor of neurology at UNC. \u201cBut it also raises caution that researchers might want to consider assessing other aspects of Angelman syndrome that might be affected by dopamine — not just motor symptoms but also other neuropsychiatric features.\u201d Malanga and Philpot are senior authors of the study.<\/p>\n

Angelman syndrome affects about every one out of every 15,000 people. Individuals with the disorder have minimal verbal communication \u2013 some never speak a single word \u2013 as well as seizures and motor problems. It is caused by defects in UBE3A, a gene involved in the development of the brain\u2019s wiring. Much of what has been learned about this gene has come from a mouse model lacking UBE3A.<\/p>\n

Philpot and Malanga decided to use these Angelman syndrome model mice to explore how dopamine is affected in Angelman syndrome. Dopamine is a well-known neurotransmitter, one of many chemicals responsible for transmitting signals between neurons in the brain. In their experiments, the researchers found that the behavioral deficits seen in the Angelman syndrome model were not due to the loss of dopamine-producing brain cells — as in Parkinson\u2019s disease — or reduced production of the important neurochemical.<\/p>\n

Rather, they found that it was associated with differences in release of the dopamine molecule from brain cells. Specifically, dopamine release was decreased in one brain pathway — the motor or nigrostriatal pathway — and increased in another — the reward or mesolimbic pathway. But instead of having a greater effect on reward, dopamine also appeared to be less effective at motivating behavior in these mice.<\/p>\n

\u201cOne of the interesting features of people with Angelman syndrome is that they generally have a very happy disposition and a lower threshold for humor. It is interesting that we found this effect in the reward pathway, because it could provide a biological basis for this happy disposition,\u201d said Philpot.<\/p>\n

Malanga cautions that this happy disposition, as well as the lack of communication skills, might make it hard for researchers to tell if their Angelman syndrome patients are experiencing negative consequences of an altered reward pathway, such as changes in mood or compulsive behaviors. Therefore, he recommends that clinical trials assess many different outcome measures to ensure that L-DOPA treatment does not lead to unanticipated outcomes.<\/p>\n

The research was funded by the National Institutes of Health, the Simons Foundation, the Angelman Syndrome Foundation and Autism Speaks. Study co-authors from UNC were Thorfinn T. Riday; Elyse C. Dankoski; Michael C. Krouse; Eric W. Fish, PhD; Paul L. Walsh; Ji Eun Han; Clyde W. Hodge, PhD; and R. Mark Wightman, PhD.<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

New research from UNC provides a neurological justification for this therapeutic approach, but researchers caution there could be unanticipated effects.<\/p>\n","protected":false},"author":80868,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3020","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"\nStudy suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"New research from UNC provides a neurological justification for this therapeutic approach, but researchers caution there could be unanticipated effects.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:published_time\" content=\"2012-11-20T01:20:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-07-05T18:58:23+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg\" \/>\n<meta name=\"author\" content=\"Nathaniel Bailey\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:site\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Nathaniel Bailey\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\"},\"author\":{\"name\":\"Nathaniel Bailey\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"headline\":\"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects\",\"datePublished\":\"2012-11-20T01:20:00+00:00\",\"dateModified\":\"2018-07-05T18:58:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\"},\"wordCount\":771,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\",\"name\":\"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects | UNC Neuroscience Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg\",\"datePublished\":\"2012-11-20T01:20:00+00:00\",\"dateModified\":\"2018-07-05T18:58:23+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage\",\"url\":\"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg\",\"contentUrl\":\"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/\",\"name\":\"UNC Neuroscience Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994\",\"name\":\"Nathaniel Bailey\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g\",\"caption\":\"Nathaniel Bailey\"},\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/author\/nathaniel-bailey\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects | UNC Neuroscience Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/","og_locale":"en_US","og_type":"article","og_title":"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects | UNC Neuroscience Center","og_description":"New research from UNC provides a neurological justification for this therapeutic approach, but researchers caution there could be unanticipated effects.","og_url":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/","og_site_name":"UNC Neuroscience Center","article_published_time":"2012-11-20T01:20:00+00:00","article_modified_time":"2018-07-05T18:58:23+00:00","og_image":[{"url":"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg","type":"","width":"","height":""}],"author":"Nathaniel Bailey","twitter_card":"summary_large_image","twitter_creator":"@uncneuro","twitter_site":"@uncneuro","twitter_misc":{"Written by":"Nathaniel Bailey","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/"},"author":{"name":"Nathaniel Bailey","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994"},"headline":"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects","datePublished":"2012-11-20T01:20:00+00:00","dateModified":"2018-07-05T18:58:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/"},"wordCount":771,"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage"},"thumbnailUrl":"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/","url":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/","name":"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects | UNC Neuroscience Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage"},"thumbnailUrl":"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg","datePublished":"2012-11-20T01:20:00+00:00","dateModified":"2018-07-05T18:58:23+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#primaryimage","url":"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg","contentUrl":"http:\/\/news.unchealthcare.org\/news\/2012\/november\/ldopa-for-angelman\/@@images\/d11d41e8-96df-42ab-b558-d92b4ac2b2b3.jpeg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neuroscience\/study-suggests-l-dopa-therapy-for-angelman-syndrome-may-have-both-benefits-and-unanticipated-effects\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neuroscience\/"},{"@type":"ListItem","position":2,"name":"Study suggests L-DOPA therapy for Angelman syndrome may have both benefits and unanticipated effects"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website","url":"https:\/\/www.med.unc.edu\/neuroscience\/","name":"UNC Neuroscience Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/5858263096b03dd1d401a4f6e847b994","name":"Nathaniel Bailey","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1cc270581bd216cabc0f29913fe2581f219e2e9cf331ed4c50c22821a81d0208?s=96&d=mm&r=g","caption":"Nathaniel Bailey"},"url":"https:\/\/www.med.unc.edu\/neuroscience\/author\/nathaniel-bailey\/"}]}},"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/neuroscience\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/3020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/users\/80868"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=3020"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/3020\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=3020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=3020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=3020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}