{"id":3079,"date":"2017-09-01T15:15:06","date_gmt":"2017-09-01T19:15:06","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/gupton-lab-featured-on-cover-of-molecular-biology-of-the-cell\/"},"modified":"2018-07-05T13:41:55","modified_gmt":"2018-07-05T17:41:55","slug":"gupton-lab-featured-on-cover-of-molecular-biology-of-the-cell","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/gupton-lab-featured-on-cover-of-molecular-biology-of-the-cell\/","title":{"rendered":"Gupton Lab Featured on Cover of Molecular Biology of the Cell"},"content":{"rendered":"
\n

<\/p>\n

The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. In this study, we detail a novel molecular mechanism by which the brain-enriched E3 ubiquitin ligase TRIM9 orchestrates multimerization of DCC, requisite activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, all during netrin-dependent neuronal morphogenesis. We are the first to show that non-degradative ubiquitination of a receptor alters kinase activation and signaling pathways during morphogenesis.<\/p>\n

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\"image2\"
Stephanie Gupton, PhD<\/figcaption><\/figure>\n<\/div>\n
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To read the full publication, click here<\/a>.<\/p>\n

For more information about the Gupton Lab, click here<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. In this study, we detail a novel molecular mechanism by which the brain-enriched E3 ubiquitin ligase TRIM9 orchestrates multimerization of DCC, requisite activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, all during netrin-dependent neuronal morphogenesis. We are the first to show that non-degradative ubiquitination of a receptor alters kinase activation and signaling pathways during morphogenesis.<\/p>\n","protected":false},"author":70069,"featured_media":3080,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[4,33,32,7],"class_list":["post-3079","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-4","tag-molecular-cellular-neuroscience","tag-molecular-biology-of-the-cell","tag-publication","odd"],"acf":[],"yoast_head":"\nGupton Lab Featured on Cover of Molecular Biology of the Cell | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/gupton-lab-featured-on-cover-of-molecular-biology-of-the-cell\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gupton Lab Featured on Cover of Molecular Biology of the Cell | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. 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