{"id":3116,"date":"2015-07-13T15:10:00","date_gmt":"2015-07-13T19:10:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/mark-zylka-awarded-rsrt-grant-for-long-genes-screening\/"},"modified":"2018-07-05T14:12:01","modified_gmt":"2018-07-05T18:12:01","slug":"mark-zylka-awarded-rsrt-grant-for-long-genes-screening","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/mark-zylka-awarded-rsrt-grant-for-long-genes-screening\/","title":{"rendered":"Mark Zylka Awarded RSRT Grant for Long Genes Screening"},"content":{"rendered":"<div>\n<p><!-- description --><\/p>\n<p class=\"lead\">Rett Syndrome Research Trust has awarded Mark Zylka $400,000 to screen for other compounds of topoisomerase inhibitors that can rebalance expression of long genes safely.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-3117\" src=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/mark-zylka-awarded-rsrt-grant-for-long-genes-screening-image2.jpeg\" alt=\"image2\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Mark Zylka, PhD<\/figcaption><\/figure>\n<\/div>\n<div>\n<p>Mark Zylka discovered that a class of drugs called topoisomerase inhibitors reduces the expression of long genes, raising the possibility that this class of drugs could be clinically relevant for Rett. One such drug is topotecan which is FDA approved for cancer. While the Greenberg lab at Harvard Medical School is currently testing Topotecan in Rett mice models, the drug may not be ideal since it doesn\u2019t get into the brain easily and would be toxic for long term use. As a result, Dr. Zylka has been awarded $400,000 from RSRT to screen for other compounds that can rebalance expression of long genes safely.<\/p>\n<p>For more information, visit the RSRT <a class=\"external-link\" title=\"\" href=\"https:\/\/rettsyndrome.wordpress.com\/2015\/07\/09\/rsrt-awards-400000-to-mark-zylka-for-long-genes-screening\/\" target=\"_blank\" rel=\"noopener\">website<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Rett Syndrome Research Trust has awarded Mark Zylka $400,000 to screen for other compounds of topoisomerase inhibitors that can rebalance expression of long genes safely.<\/p>\n","protected":false},"author":40519,"featured_media":3117,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3116","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mark Zylka Awarded RSRT Grant for Long Genes Screening | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/mark-zylka-awarded-rsrt-grant-for-long-genes-screening\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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