{"id":3138,"date":"2014-12-08T15:55:00","date_gmt":"2014-12-08T20:55:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/philpot-and-zylka-labs-pinpoint-chemo-effect-on-brain-cells\/"},"modified":"2018-07-05T14:19:05","modified_gmt":"2018-07-05T18:19:05","slug":"philpot-and-zylka-labs-pinpoint-chemo-effect-on-brain-cells","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/philpot-and-zylka-labs-pinpoint-chemo-effect-on-brain-cells\/","title":{"rendered":"Philpot and Zylka Labs pinpoint chemo effect on brain cells"},"content":{"rendered":"

Ben Philpot, PhD, and Mark Zylka, PhD, discovered a biochemical mechanism that could cause “chemo brain”, the neurological side effects of chemotherapy.<\/p>\n

\n

Ben Philpot and Mark Zylka have discovered a biochemical mechanism that could be the cause of the neurological side effects of chemotherapy, including memory loss, confusion, difficulty thinking, and trouble concentrating.<\/p>\n

Their research, found in Proceedings of the National Academy of Sciences<\/a> and recently feature in the News and Observer<\/a>, shows how the drug topotecan, commonly used in chemotherapy, can drastically suppress the expression of Topoisomerase-1, a gene that triggers the creation of proteins essential for normal brain functions. While the drug is present in the cells, they are in a dormant state; however, after the drug is eliminated, the synaptic function returned to normal.<\/p>\n

In addition to the chemotherapy implications, they suggest that if these enzymes are affected during brain development, the result could be long-term neurodevelopmental problems, such as those found in people with Autism Spectrum Disorder.<\/p>\n

For more information, visit the UNC Newsroom<\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

Ben Philpot, PhD, and Mark Zylka, PhD, discovered a biochemical mechanism that could cause “chemo brain”, the neurological side effects of chemotherapy.<\/p>\n","protected":false},"author":40519,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3138","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"\nPhilpot and Zylka Labs pinpoint chemo effect on brain cells | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/philpot-and-zylka-labs-pinpoint-chemo-effect-on-brain-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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