{"id":3140,"date":"2016-03-31T21:09:41","date_gmt":"2016-04-01T01:09:41","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/philpot-lab-publishes-research-in-neuron\/"},"modified":"2018-07-05T14:03:28","modified_gmt":"2018-07-05T18:03:28","slug":"philpot-lab-publishes-research-in-neuron","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/philpot-lab-publishes-research-in-neuron\/","title":{"rendered":"Philpot lab publishes research in Neuron"},"content":{"rendered":"
\n

<\/p>\n

In the journal Neuron, Ben Philpot, PhD, professor of cell biology and physiology, published his lab\u2019s research analyzing the spatial determinants for UBE3A loss in the development of seizures and other hyperexcitability phenotypes in the brain<\/p>\n

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In the journal Neuron<\/i>, Ben Philpot, PhD, professor of cell biology and physiology, published his lab\u2019s research analyzing the spatial determinants for UBE3A loss in the development of seizures and other hyperexcitability phenotypes in the brain. Philpot\u2019s team used novel mouse models to show that selective UBE3A loss from GABAergic brain circuits \u2013 comprising neurons that release the inhibitory neurotransmitter GABA \u2013 led to the same kinds of seizure behaviors and electroencephalographic (EEG) abnormalities typically found in AS model mice, which lack UBE3A in all neurons.<\/p>\n

Matt Judson, PhD, the study\u2019s first author and a research associate in Philpot\u2019s lab, said that the findings open the door for further investigations into the specific effects of UBE3A loss in other types of neurons.<\/p>\n

For more information, visit the UNC News Room<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

In the journal Neuron, Ben Philpot, PhD, professor of cell biology and physiology, published his lab\u2019s research analyzing the spatial determinants for UBE3A loss in the development of seizures and other hyperexcitability phenotypes in the brain<\/p>\n","protected":false},"author":40519,"featured_media":3141,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3140","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nPhilpot lab publishes research in Neuron | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/philpot-lab-publishes-research-in-neuron\/\" \/>\n<meta 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