{"id":3149,"date":"2015-05-20T20:31:58","date_gmt":"2015-05-21T00:31:58","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/roth-lab-demonstrates-how-brain-circuits-control-mice-behavior\/"},"modified":"2018-07-05T14:15:33","modified_gmt":"2018-07-05T18:15:33","slug":"roth-lab-demonstrates-how-brain-circuits-control-mice-behavior","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/roth-lab-demonstrates-how-brain-circuits-control-mice-behavior\/","title":{"rendered":"Roth Lab Discovers New Tool to Study and Control Brain Circuits"},"content":{"rendered":"<div>\n<p><!-- description --><\/p>\n<p class=\"lead\">Using a new \u2018chemogenetic\u2019 technique invented by Bryan Roth\u2019s lab at UNC, scientists turn neurons \u2018on\u2019 and \u2018off\u2019 to demonstrate how brain circuits control behavior in mice. This unique tool \u2013 the first to result from the NIH BRAIN Initiative \u2013 will help scientists understand how to modulate neurons to more effectively treat diseases.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3150\" src=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/roth-lab-demonstrates-how-brain-circuits-control-mice-behavior-image2-300x205.jpeg\" alt=\"image2\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Bryan L Roth, MD, PhD<\/figcaption><\/figure>\n<\/div>\n<div>\n<div class=\"plain\">Roth lab has perfected a noninvasive \u201cchemogenetic\u201d technique that allows researchers to turn off a specific behavior in mice and then switch it back on. The method they named KORD (k-opioid receptor DREADD) was funded by the NIH BRAIN Initiative It works by targeting two different cell surface receptors of neurons that are responsible for triggering the specific chemical signals that control brain functions and complex behaviors. The KORD technology will play a role in showing how brain circuits can be more effectively targeted to treat human disease.<\/div>\n<p>For more information, visit the <a class=\"external-link\" title=\"A BRAIN Initiative first\" href=\"http:\/\/news.unchealthcare.org\/news\/2015\/april\/new-brain-initiative-technology-can-switch-behavior-2018on2019-and-2018off2019\" target=\"_blank\" rel=\"noopener\">UNC School of Medicine Newsroom<\/a>.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Using a new \u2018chemogenetic\u2019 technique invented by Bryan Roth\u2019s lab at UNC, scientists turn neurons \u2018on\u2019 and \u2018off\u2019 to demonstrate how brain circuits control behavior in mice. This unique tool \u2013 the first to result from the NIH BRAIN Initiative \u2013 will help scientists understand how to modulate neurons to more effectively treat diseases.<\/p>\n","protected":false},"author":40519,"featured_media":3150,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3149","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Roth Lab Discovers New Tool to Study and Control Brain Circuits | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/roth-lab-demonstrates-how-brain-circuits-control-mice-behavior\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Roth Lab Discovers New Tool to Study and Control Brain Circuits | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"Using a new \u2018chemogenetic\u2019 technique invented by Bryan Roth\u2019s lab at UNC, scientists turn neurons \u2018on\u2019 and \u2018off\u2019 to demonstrate how brain circuits control behavior in mice. 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