{"id":7367,"date":"2025-07-01T12:01:39","date_gmt":"2025-07-01T16:01:39","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/?p=7367"},"modified":"2025-07-01T12:02:20","modified_gmt":"2025-07-01T16:02:20","slug":"alzheimers-risk-gene-may-disrupt-brain-health","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/alzheimers-risk-gene-may-disrupt-brain-health\/","title":{"rendered":"Alzheimer\u2019s risk gene may disrupt brain health"},"content":{"rendered":"<p dir=\"ltr\">A discovery by a\u00a0<a href=\"https:\/\/www.med.unc.edu\/\" target=\"_blank\" rel=\"noopener\">UNC School of Medicine<\/a>\u00a0cell biology lab could reshape how scientists understand and treat Alzheimer\u2019s disease.<\/p>\n<p dir=\"ltr\">The research team is led by\u00a0<a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/sarah-cohen-phd\/\">Sarah Cohen<\/a>, assistant professor in the medical school\u2019s cell biology and physiology department and member of the\u00a0<a href=\"https:\/\/unclineberger.org\/\" target=\"_blank\" rel=\"noopener\">UNC Lineberger Comprehensive Cancer Center<\/a>.<\/p>\n<p dir=\"ltr\">Cohen\u2019s lab found that Apolipoprotein E4, a protein long known as the strongest genetic risk factor for late-onset Alzheimer\u2019s, has a surprising effect on certain brain cells.<\/p>\n<p dir=\"ltr\">Original full article can be found <a href=\"https:\/\/www.unc.edu\/posts\/2025\/06\/17\/alzheimers-risk-gene-may-disrupt-brain-health\/\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\n<p dir=\"ltr\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-7301\" src=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2024\/12\/Sarah-Cohen-200x300-1.jpg\" alt=\"\" width=\"200\" height=\"300\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A discovery by a\u00a0UNC School of Medicine\u00a0cell biology lab could reshape how scientists understand and treat Alzheimer\u2019s disease. The research team is led by\u00a0Sarah Cohen, assistant professor in the medical school\u2019s cell biology and physiology department and member of the\u00a0UNC Lineberger Comprehensive Cancer Center. Cohen\u2019s lab found that Apolipoprotein E4, a protein long known as &hellip; <a href=\"https:\/\/www.med.unc.edu\/neuroscience\/alzheimers-risk-gene-may-disrupt-brain-health\/\" aria-label=\"Read more about Alzheimer\u2019s risk gene may disrupt brain health\">Read more<\/a><\/p>\n","protected":false},"author":7858,"featured_media":7301,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-7367","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alzheimer\u2019s risk gene may disrupt brain health | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/alzheimers-risk-gene-may-disrupt-brain-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s risk gene may disrupt brain health | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"A discovery by a\u00a0UNC School of Medicine\u00a0cell biology lab could reshape how scientists understand and treat Alzheimer\u2019s disease. The research team is led by\u00a0Sarah Cohen, assistant professor in the medical school\u2019s cell biology and physiology department and member of the\u00a0UNC Lineberger Comprehensive Cancer Center. Cohen\u2019s lab found that Apolipoprotein E4, a protein long known as &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/alzheimers-risk-gene-may-disrupt-brain-health\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-01T16:01:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-01T16:02:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2024\/12\/Sarah-Cohen-200x300-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sue Modlin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncneuro\" \/>\n<meta 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