{"id":7436,"date":"2025-12-04T12:00:03","date_gmt":"2025-12-04T17:00:03","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/?p=7436"},"modified":"2025-12-04T13:29:24","modified_gmt":"2025-12-04T18:29:24","slug":"tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/","title":{"rendered":"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex"},"content":{"rendered":"<p>Congratulations to Neuroscience Center Dr. Eva Anton and Dr. Jason Stein for their recent publication in Nature!<\/p>\n<p>Casingal et al. finds that TSC proteins regulate the balance between radial and intermediate progenitors, shaping cortical organization and upper-layer neuron production. <span data-olk-copy-source=\"MessageBody\">Evolutionary downregulation of TSC expression in humans likely supports expansion of upper layer neurons necessary for the development of complex cognitive functions.<\/span><\/p>\n<p>Full publication can be found <a href=\"https:\/\/www.nature.com\/articles\/s41586-025-09810-5?WT.ec_id=NATURE-202512\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Neuroscience Center Dr. Eva Anton and Dr. Jason Stein for their recent publication in Nature! Casingal et al. finds that TSC proteins regulate the balance between radial and intermediate progenitors, shaping cortical organization and upper-layer neuron production. Evolutionary downregulation of TSC expression in humans likely supports expansion of upper layer neurons necessary for &hellip; <a href=\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\" aria-label=\"Read more about Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex\">Read more<\/a><\/p>\n","protected":false},"author":96491,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-7436","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"Congratulations to Neuroscience Center Dr. Eva Anton and Dr. Jason Stein for their recent publication in Nature! Casingal et al. finds that TSC proteins regulate the balance between radial and intermediate progenitors, shaping cortical organization and upper-layer neuron production. Evolutionary downregulation of TSC expression in humans likely supports expansion of upper layer neurons necessary for &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-04T17:00:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-04T18:29:24+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:site\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\"},\"author\":{\"name\":\"\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/4ed09047c0dd4a42adfeb4b3b58284b4\"},\"headline\":\"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex\",\"datePublished\":\"2025-12-04T17:00:03+00:00\",\"dateModified\":\"2025-12-04T18:29:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\"},\"wordCount\":82,\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\",\"name\":\"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex | UNC Neuroscience Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\"},\"datePublished\":\"2025-12-04T17:00:03+00:00\",\"dateModified\":\"2025-12-04T18:29:24+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/4ed09047c0dd4a42adfeb4b3b58284b4\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/\",\"name\":\"UNC Neuroscience Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/4ed09047c0dd4a42adfeb4b3b58284b4\",\"name\":\"\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/df33fc64d74e94c5c724cac1b4e5d1fdc95cd880fb2456ceb936f10bc86edafc?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/df33fc64d74e94c5c724cac1b4e5d1fdc95cd880fb2456ceb936f10bc86edafc?s=96&d=mm&r=g\"},\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/author\/-7021\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex | UNC Neuroscience Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/","og_locale":"en_US","og_type":"article","og_title":"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex | UNC Neuroscience Center","og_description":"Congratulations to Neuroscience Center Dr. Eva Anton and Dr. Jason Stein for their recent publication in Nature! Casingal et al. finds that TSC proteins regulate the balance between radial and intermediate progenitors, shaping cortical organization and upper-layer neuron production. Evolutionary downregulation of TSC expression in humans likely supports expansion of upper layer neurons necessary for &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/","og_site_name":"UNC Neuroscience Center","article_published_time":"2025-12-04T17:00:03+00:00","article_modified_time":"2025-12-04T18:29:24+00:00","twitter_card":"summary_large_image","twitter_creator":"@uncneuro","twitter_site":"@uncneuro","twitter_misc":{"Written by":"","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/"},"author":{"name":"","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/4ed09047c0dd4a42adfeb4b3b58284b4"},"headline":"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex","datePublished":"2025-12-04T17:00:03+00:00","dateModified":"2025-12-04T18:29:24+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/"},"wordCount":82,"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/","url":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/","name":"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex | UNC Neuroscience Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website"},"datePublished":"2025-12-04T17:00:03+00:00","dateModified":"2025-12-04T18:29:24+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/4ed09047c0dd4a42adfeb4b3b58284b4"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neuroscience\/tsc-tunes-progenitor-balance-and-upper-layer-neuron-generation-in-neocortex\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neuroscience\/"},{"@type":"ListItem","position":2,"name":"Published in Nature, study reveals TSC tunes progenitor balance and upper-layer neuron generation in neocortex"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website","url":"https:\/\/www.med.unc.edu\/neuroscience\/","name":"UNC Neuroscience Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/4ed09047c0dd4a42adfeb4b3b58284b4","name":"","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/df33fc64d74e94c5c724cac1b4e5d1fdc95cd880fb2456ceb936f10bc86edafc?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/df33fc64d74e94c5c724cac1b4e5d1fdc95cd880fb2456ceb936f10bc86edafc?s=96&d=mm&r=g"},"url":"https:\/\/www.med.unc.edu\/neuroscience\/author\/-7021\/"}]}},"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/neuroscience\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/7436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/users\/96491"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/comments?post=7436"}],"version-history":[{"count":6,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/7436\/revisions"}],"predecessor-version":[{"id":7442,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/posts\/7436\/revisions\/7442"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=7436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/categories?post=7436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/tags?post=7436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}