Education & Research

Recent Divisional Publications

• Carboplatin dosing in the treatment of ovarian cancer: An NRG oncology group study May 25, 2023
  CONCLUSION: The formula used to estimate CrCl affects carboplatin dosing. Estimated CrCl
  Aaron M Praiss
• PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin May 11, 2023
  Endometrial epithelia are known to harbor cancer driver mutations in the absence of any pathologies, including mutations in PIK3CA. Insulin plays an important role in regulating uterine metabolism during pregnancy, and hyperinsulinemia is associated with conditions impacting fertility. Hyperinsulinemia also promotes cancer, but the direct action of insulin on mutated endometrial epithelial cells is unknown. […]
  Mike R Wilson
• The effect of older age on treatment outcomes in women with advanced ovarian cancer receiving chemotherapy: An NRG-Oncology/Gynecologic Oncology Group (GOG-0182-ICON5) ancillary study May 6, 2023
  CONCLUSIONS: In women with advanced EOC receiving chemotherapy, age ≥ 70 was associated with shorter OS and cancer specific survival. Older patients receiving carboplatin and paclitaxel reported higher rates of grade ≥ 2 neuropathy but were not more likely to suffer from other chemotherapy related toxicities. Clintrials.gov: NCT00011986.
  Tiffany Y Sia
• Tissue factor-positive extracellular vesicles in plasma are not associated with venous thromboembolism in patients with ovarian cancer May 2, 2023
  No abstract
  Yohei Hisada
• A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer April 18, 2023
  Poly ADP-ribose polymerase (PARP) inhibitors are effective therapies for cancer patients with homologous recombination (HR) deficient tumors. The imipridone ONC206 is an orally bioavailable dopamine receptor D2 antagonist and mitochondrial protease ClpP agonist that has anti-tumorigenic effects in endometrial cancer via induction of apoptosis, activation of the integrated stress response and modulation of PI3K/AKT signaling. […]
  Sarah E Paraghamian