Reciprocal Regulation of Acute and Chronic Virulence Factor Expression in Pseudomonas aeruginosa During Cystic Fibrosis Airway Infection



Kimberly Coggan


Research Mentor:

Dr. Matthew Wolfgang, PhD


Clinical Co-Mentor;

Dr. Richard Boucher, MD

Project Description:

Kimberly studies how the pathogenic bacterium Pseudomonas aeruginosa converts from production of acute to chronic virulence factors. As part of her studies she will compare the gene expression profile of P. aeruginosa during acute infection with bacteria from chronically infected patients with cystic fibrosis. Understanding control of virulence factor production will lead to new therapies.