Fighting Pseudomonas aeruginosa Bacterial Pneumonia



Julianne Huang


Research Mentor:

Matt Redinbo


Clinical Co-mentor:

Stephen Tilley

Home Department Chemistry
Project Description Critical-care infection rates can be as high as 70% in ICU patients hospitalized for longer than 7 days. Pseudomonas aeruginosa is the principal gram-negative opportunistic bacterial pathogen in nosocomial pneumonias. Furthermore, P. aeruginosa is the leading multi-drug resistant (MDR) gram-negative organism causing ventilator associated pneumonia (VAP) in both ICU and burn patients. We seek to investigate new potential prophylactic agents for this pathogen. The Redinbo group has recently shown that the P. aeruginosa type IV pilus-associated factor PilY1 has several atomic features relevant to initiating and establishing infections. We will use those data to investigate prophylactic therapies for bacterial pneumonia.