DPLM Faculty Profiles — Dr. Godfrey

Virginia Godfrey

Virginia L. Godfrey, DVM, PhD

Professor

Office: 919-966-2903

E-mail: vgodfrey@med.unc.edu

Research Interests

My interests include veterinary pathology, animal models of disease, T cell development and biology, and autoimmunine disease.

Selected Publications

Castillo A, Morse HC, Godfrey VL, Naeem R, Justice, MJ. 2007. Misexpression of Eg5 causes genomic instability and tumor formation in mice. Cancer Research. In press.

Bultman SJ, Herschkowitz JI, Godfrey V, Gebuhr TC, Yaniv M, Perou CM, Magnuson T. 2007. Characterization of mammary tumors in Brg1 heterozygous mice. Oncogene. Jul 16 [Epub ahead of print].

Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Yan, Wang Y, Liu X, Chan M, Liu J-Q, Love R, Liu C-g, Godfrey V, Shen R, Huang T, Yang T, Park B, Wang C-Y, Zheng P, Liu Yang. 2007. FOXP3 is an X-linked breast suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell. Jun 29; 129(7): 1275-86.

Chai J, Lu X, Godfrey V, Fletcher C, Roberts CW, Van Dyke T, Weissman BE. 2007. Tumor-specific cooperation of retinoblastoma family and Snf5 inactivation. Cancer Res. Apr.1: 67(7): 3002-9.

Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V, Koller BH. 2006. Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice. Mol. Cell Biol. 26(24): 9571.

Chang X, Chen L, Jing W, Godfrey VL, Qiao G, Hussien Y, Zhang J, Gao JX 2006. Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Clin. Immunol. 121(3): 274-285.

Garcia-Contreras L, Sethuraman V, Kazantseva M, Godfrey V, Hickey AJ. 2006. Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. J. Antimicrobial Chemotherapy. 58: 980-986. The Mouse in Biomedical Research, Second Edition, Volume 2: Diseases. Elsevier Inc. San Diego, CA. Eds. James G. Fox, Christian Newcomer, Abigail Smith, Stephen Barthold, Fred Quimby, Muriel Davisson. Chapter 20: Fungal diseases in laboratory mice, pp. 507-514. 2007.

Bissahoyo A, Pearsall RS, Hanlon K, Amann V, Hicks D, Godfrey VL, Threadgill DW. 2005. Azoxymethane is a genetic background-dependent colorectal tumor initiator and promotor in mice: effects of dose, route, and diet. Toxicol. Sci. 88(2): 340-5.

Chang X, Gao JX, Jiang Q, Wen J, Seifers N, Su L, Godfrey VL, Zuo T, Zheng P, Liu Y. 2005. The scurfy mutation of foxp3 in the thymic stroma lead to defective thymopoieisis and over-expression of the erbB2 gene. J. Exp. Med. 202(8): 1141-51.

Werner CG, Godfrey V, Arnold RR, Featherstone GL, Bender D, Schlossmann J, Schiemann M, Hofmann F, Pryzwansky KB. 2005. Neutrophil dysfunction in guanosine 3’, 5’-cyclic monophosphate-dependent protein kinase I – deficient mice. J. Immunol. 175:1919–1929.

Gebuhr TC, Kovalev GI, Bultman S, Godfrey V, Su L, Magnuson T. 2003. The role of Brg 1, a catalytic subunit of mammalian chromatin- remodeling complexes, in T cell development. J Exp Med 198(12):1937-49.

Dai Q, Zhang C, Wu Y, McDonough H, Whaley R, Godfrey V, Li H-H, Madamanchi N, Xu W, Neckers L, Cyr D, Patterson C. 2003. CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J. 22(20): 1-13.

Boivin GP, Washington K, Yang K, Ward J, Pretlow TP, Russell R, Besselsen DG, Godfrey VL, Doetschman T, Groden J, Halberg RB, Itzkowitz SH, Coffey RJ. 2003. Pathology of mouse models of intestinal cancer: Consensus report and recommendations. Gastroenterology. 124(3): 762-777.

Bai F , Pei X-H , Godfrey VL, Xiong Y. 2003. Haploinsufficiency of p18INK4c sensitizes mice to carcinogen-induced tumorigenesis . Mole. Cell. Biol. 23(4): 1269-1277.

Southern KW, Funkhouser WK, Kazachkova I, Godfrey VL, Fordham LA, Gatzy JT, Barker PM. 2002. Airway surface liquid recovered by lavage with perfluorocarbon liquid in cats. Eur. J Clin. Invest. 32(12): 956-61.

Backlund MG. Trasti SL. Backlund DC. Cressman VL. Godfrey V. Koller BH. 2001. Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice. Cancer Research. 61(17):6577-82.

Franklin DS, Godfrey VL, O’Brien DA, Deng C, Xiong Y. 2000. Functional collaboration between differnent cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificities. Mole. Cell. Biol. 20 (16): 6147-6158.

Makris C, Godfrey VL, Krahn-Senftleben G, Takahashi T, Roberts JL, Schwatz, T, Fene L, Johnson RS, Karin M. 2000. Female mice heterozygous for IKK?/NEMO deficiencies develop a dermatopathy similar to human X-linked disorder Incontinentia Pigmenti. Molecular Cell, 5(6): 969-979.

Nishimura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T, Brenner DA, Meyer AA. 2000. Gene expression and cytomkine and enzyme activation in the liver after a burn injury. J. of Burn Care & Rehabilitation, 21(2): 135-141.

Cressman VL, Backlund DC, Arutskaya AV, Leadon SA, Godfrey V, and BH Koller. 1999. Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA-1 deficient mice. Molecular & Cellular Biology. 19(10): 7061-7075.

Schultz M, Tonkonogy SL, Sellon RK, Velkamp C, Godfrey VL, Grenther WB, Balish E, Horak I, Sartor RB. 1999. Interleukin-2 deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. American Journal of Physiology. 276(6 Pt.1), G1461-1472.

Cressman VL, Backlund DC, Hicks EM, Gowen LC, Godfrey V, Koller BH. 1999. Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth and Differentiation. 10, 1-10.

Kulwichit W, Hood RE, Davenport EM, Baskar JF, Godfrey V, Raab-Traub N. 1998. Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. PNAS. 95, 11963-11968.

Franklin DS, Godfrey VL, Lee H, Kovalev GI, O’Brien DA, Schoonhoven R, Chen-Kiang S, Su L, Xiong Y. 1998. CDK Inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes and Development . 12, 2899-2911.

Weintraub JP, Godfrey V, Wolthusen PA, Cheek RL, Eisenberg RA, Cohen. PL 1997. Immunological and pathological consequences of mutations in both Fas and Fas ligand. Cellular Immunology. 186(1), 8-17.

Potter MD, Shinpock SG, Popp RA, Godfrey V, Carpenter DA, Bernstein A, Johnson DK, Rinchik EM. 1997 Mutations in the murine fitness 1 gene result in defective hematopoiesis. Blood. 90(5), 1850-1857.

Kanangat S, Blair P, Reddy R, Deheshia M, Godfrey V, Rouse B, Wilkinson E. 1996. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes. European Journal of Immunology. 26(1), 161-165.

Dees C, Godfrey VL, Schultz RD, Travis CC. 1996. Wild-type p53 reduces the size of tumors caused by bovine leukemia virus-infected cells. Cancer Letters. 101(1), 115-122.

Banks TA, Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin NA, Bouley DM, Thomas J, Kanangat S, Mucenski MM. 1995. Lymphotoxin -?-deficient mice: Effects on secondary lymphoid organ development and humoral responsiveness. J. Immunol. 155(4), 1685-93.

Derry JMJ, Wiedeman P, Blair PJ, Wang Y, Kearns JA, Lemahieu V, Godfrey VL, Wilkinson JE, Francke U. 1995. The murine homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near scurfy (sf) on the mouse X chromosome. Genomics. 29, 471-477.

Niemialtowski MG, Godfrey VL, Rouse BT. 1994. Quantitative studies on CD4+ and CD8+ cytotoxic T lymphocyte responses against herpes simplex virus type 1 in normal and beta 2-microglobulin deficient mice. Immunobiology. 190(3), 183-194.

Dees C, Godfrey VL, Foster JS, Schultz RD, Travis CC. 1994. Stabilization of the p53 gene product in two bovine leukemia virus - infected cell lines. Cancer Letters. 86, 33-40.

Blair PJ, Carpenter DA, Godfrey VL, Russell LB, Wilkinson JE, Rinchik EM. 1994. The mouse scurfy (sf) mutation is tightly linked to Gata-1 and Tfe-3 on the proximal X chromosome. Mamm. Genome. 5, 652-654.

Blair PJ, Wilkinson JE, Rouse B, Godfrey VL. 1994. CD4 T cells are the critical mediators of disease in the scurfy mouse. J. Immunol. 153, 3764-3774.

Moyer JH, Lee-Tischler MJ, Kwon H-Y, Schrick J, Avner ED, Sweeney WE, Godfrey VL, Cacheiro NLA, Wilkinson JE, Woychik RP. 1994. Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science. 264, 1329-1333.

Godfrey VL, Rouse BT, Wilkinson JE. 1994. Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse. Amer. J. Pathol. 145 (2), 218-286.

Selkirk JK, Hite MC, Godfrey V, Merrick BA, He C, Griesemer RA, Daluge DR, Mansfield BK. 1992. Two-dimensional polyacrylamide gel electrophorectic characterization of proteins from the organs of C3H mice expressing the scurfy (sf) mutation during early and late stages of disease progression. Applied and Theoretical Electrophoresis 3, 97-107.

Kennel SJ, Godfrey VL, Ch'ang LY, Lankford TK, Foote LJ, Makkinje A. 1992. The b4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice. J. Cell Sci. 101, 145-150.

Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB. 1991. Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment. Proc. Natl. Acad. Sci. (USA) 88, 5528-5532.

Godfrey VL, Wilkinson JE, Russell LB. 1991. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol, 138(6), 1379-1387.

Riond JL, Cullen JM, Godfrey VL, Hunt EL, Anderson KL. 1990. Bovine viral diarrhea virus-induced cerebellar disease in a calf. J Am Vet Med Assoc. 197(12): 1631-2.