DPLM Faculty Profiles — Dr. Liu

Dr. Liu

Jiandong Liu, PhD

Assistant Professor

Office: 919-962-0326

E-mail: jiandong_liu@med.unc.edu

Lab web site: http://liulab.web.unc.edu

Research Interests

Figure 1

Congenital heart diseases are one of the most common birth defects in humans, and these arise from developmental defects during embryogenesis. Many of these diseases have a genetic component, but they might also be affected by environmental factors such as mechanical forces. The Liu Lab combines genetics, molecular and cell biology to study cardiac development and function, focusing on the molecular mechanisms that link mechanical forces and genetic factors to the morphogenesis of the heart. Our studies using zebrafish as a model system serve as the basic foundation to address the key questions in cardiac development and function, and could provide novel therapeutic interventions for cardiac diseases.

Selected Publications

Liu J and Stainier DY (2012). Zebrafish in the study of early cardiac development. Circ Res. 110: 870-874.

Qian L., Wythe JD., Liu J., Cartry J., Vogler G., Mohapatra B., Otway RT., HuanG Y., King IN., Crawley T., Taghli-Lamallem O., Semsarian C., Dunwoodie S., Winlaw D.,Harvey RP., Fatkin D., Towbin JA., Zheng Y., Molkentin J., Srivastava D., Ocorr K., Bruneau BG., and Bodmer R. (2011). A tinman/Nkx2-5 Interaction Screen Identifies the Small Rho-GTPase, Cdc42, as a Regulator of Adult Heart Function. J Cell Biol. 193(7):1181-1196

Liu J., Bressan M., Hassel D., Huisken J., Staudt D., Kikuchi K., Poss KD., Mikawa T., and Stainier D.Y.R. (2010). A dual role for ErbB2 signaling in cardiac trabeculation. Development. 137:3867-3875.

Liu, J. and Stainier, D.Y.R. (2010). Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish. Circ Res. 106:1818-1828.

Qian L., Mohapatra B., Akasaka T., Liu J., Ocorr K., Towbin J.A., and Bodmer R. (2008). Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proc. Natl. Acad. Sci. U.S.A. 105:19833-19838.

Liu J., Qian L., Han Z., Wu X., and Bodmer R. (2008). Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Dev. Biol. 313, 876-886.

Liu J., Qian L., Wessells R.J., Bidet Y., Jagla K., and Bodmer R (2006). Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells. Dev. Biol. 290, 373-385.

Wang D., Qian L., Xiong H., Liu J., Neckameyer W.S., Oldham S., Wang J., Xia K., Bodmer R., and Zhang Z. (2006). Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 103, 13520-13525.

Fujioka M., Wessells R.J., Han Z., Liu J., Fitzgerald K., Yusibova G.L., Zamora M., Ruiz-Lozano P., Bodmer R., and Jaynes JB (2005). Embryonic Even Skipped-Dependent Muscle and Heart Cell Fates Are Required for Normal Adult Activity, Heart Function, and Lifespan. Circ Res. 97, 1108-1114.

Qian L., Liu J., and Bodmer R. (2005). Neuromancer (H15/midline) T-box20-related genes promote cell fate specification and morphogenesis of the Drosophila heart. Dev. Biol. 279, 509–524.

Qian L., Liu J., and Bodmer R. (2005). Slit and Robo control cardiac cell polarity and morphogenesis. Curr. Biol. 15, 2271-2278.