{"id":4260,"date":"2024-01-30T19:06:33","date_gmt":"2024-01-30T19:06:33","guid":{"rendered":"https:\/\/www.med.unc.edu\/oor\/experts\/?post_type=faculty-expert&p=4260"},"modified":"2024-09-30T13:19:56","modified_gmt":"2024-09-30T17:19:56","slug":"richard-c-boucher-md","status":"publish","type":"faculty-expert","link":"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/richard-c-boucher-md\/","title":{"rendered":"Richard C. Boucher, MD"},"content":{"rendered":"

Dr. Boucher\u2019s lab has focused on the normal physiology of airway surface liquids (ASL) and how this system fails in airways diseases, e.g., cystic fibrosis and COPD. The lab pursues a variety of investigations into the functions of airway epithelia in health and disease. In general terms, the lab focuses on five interrelated areas of research:<\/p>\n

    \n
  1. Airway Surface Liquid (ASL) physiology in health and how it fails in major airways diseases, e.g. the \u201cdehydration hypothesis as relates to CF\u201d.<\/li>\n
  2. Airway epithelial Na+ transport, including studies of normal regulation of airway epithelial Na+ transport, and role of Na+ transport in airways disease, including mouse models over-expressing subunits of the epithelial Na+ channel (ENaC).<\/li>\n
  3. Extracellular nucleotides and their role in airways homeostasis, including the role of P2 receptors in airway epithelial function, extracellular nucleotidases; and measuring the rates of metabolism of nucleotides and nucleotide release from cells.<\/li>\n
  4. Gene therapy for CF lung disease, particularly focusing on investigations of barriers to gene transfer, and improved vector targeting.<\/li>\n
  5. Clinical studies: a current area of interest focuses on Na+ channel blockers and hypertonic saline.<\/li>\n<\/ol>\n","protected":false},"featured_media":4261,"template":"","meta":{"_acf_changed":false},"affiliation":[206,49,60],"database-category":[297],"expert-year":[287],"class_list":["post-4260","faculty-expert","type-faculty-expert","status-publish","has-post-thumbnail","hentry","affiliation-dom-pulm","affiliation-medicine","affiliation-marsico-lung-institute","database-category-respiratory-care-and-diseases","expert-year-287","odd"],"acf":[],"yoast_head":"\nRichard C. Boucher, MD | UNC Expertscape-ranked Faculty<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/richard-c-boucher-md\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Richard C. Boucher, MD | UNC Expertscape-ranked Faculty\" \/>\n<meta property=\"og:description\" content=\"Dr. Boucher\u2019s lab has focused on the normal physiology of airway surface liquids (ASL) and how this system fails in airways diseases, e.g., cystic fibrosis and COPD. The lab pursues a variety of investigations into the functions of airway epithelia in health and disease. In general terms, the lab focuses on five interrelated areas of … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/richard-c-boucher-md\/\" \/>\n<meta property=\"og:site_name\" content=\"Expert Database\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-30T17:19:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/oor\/experts\/wp-content\/uploads\/sites\/1368\/2024\/01\/RBoucher.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"200\" \/>\n\t<meta property=\"og:image:height\" content=\"242\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/richard-c-boucher-md\/\",\"url\":\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/richard-c-boucher-md\/\",\"name\":\"Richard C. 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