{"id":4282,"date":"2024-01-30T19:32:33","date_gmt":"2024-01-30T19:32:33","guid":{"rendered":"https:\/\/www.med.unc.edu\/oor\/experts\/?post_type=faculty-expert&#038;p=4282"},"modified":"2024-07-23T22:52:19","modified_gmt":"2024-07-24T02:52:19","slug":"kathleen-m-caron-phd","status":"publish","type":"faculty-expert","link":"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/kathleen-m-caron-phd\/","title":{"rendered":"Kathleen M. Caron, PhD"},"content":{"rendered":"<p>Studies in the Caron Lab are focused on elucidating unique G protein-coupled receptor pathways that are important for the development and function of the cardiovascular system. Using a variety of gene-targeted animal models in conjunction with state-of-the-art\u00a0<em>in vitro<\/em>\u00a0cell biological systems, we have discovered fundamental roles for several secretin- and chemokine-family receptors in cardiovascular development and disease. Much of our recent work has focused on the pivotal roles that RAMPs (receptor activity-modifying proteins) play in controlling receptor function, cellular signaling, and physiology. The importance of the RAMP-receptor interaction is best exemplified by our work centered on the small blood protein, adrenomedullin \u2013 a potent lymphangiogenic vasodilator that serves as a strong prognostic indicator for many disease conditions.<\/p>\n","protected":false},"featured_media":4284,"template":"","meta":{"_acf_changed":false},"affiliation":[20],"database-category":[307],"expert-year":[287],"class_list":["post-4282","faculty-expert","type-faculty-expert","status-publish","has-post-thumbnail","hentry","affiliation-cellbio","database-category-circulatory-system-health-and-disorders","expert-year-287","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Kathleen M. 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