{"id":4344,"date":"2024-01-31T13:06:07","date_gmt":"2024-01-31T18:06:07","guid":{"rendered":"https:\/\/www.med.unc.edu\/oor\/experts\/?post_type=faculty-expert&p=4344"},"modified":"2024-09-30T13:16:17","modified_gmt":"2024-09-30T17:16:17","slug":"yohei-hisada-phd","status":"publish","type":"faculty-expert","link":"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/yohei-hisada-phd\/","title":{"rendered":"Yohei Hisada, PhD"},"content":{"rendered":"

My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. I have found that tumor-derived tissue factor positive extracellular vesicles, neutrophils and neutrophil extracellular traps, and plasminogen activator inhibitor-1 independently contribute to venous thrombosis in mouse models of pancreatic cancer. Another interest is the mechanisms of acute leukemia-associated disseminating intravascular coagulation. I am currently investigating the levels of different biomarkers that reflect activation of coagulation and fibrinolysis, as well as fibrinolysis inhibitors in plasma samples from patients with different types of acute leukemia. I am also developing mouse models of acute leukemia to study the roles of host cells versus leukemia cells and different coagulation and fibrinolysis proteins and their inhibitors in acute leukemia-associated disseminated intravascular coagulation.<\/p>\n","protected":false},"featured_media":4345,"template":"","meta":{"_acf_changed":false},"affiliation":[201,213,49],"database-category":[307],"expert-year":[287],"class_list":["post-4344","faculty-expert","type-faculty-expert","status-publish","has-post-thumbnail","hentry","affiliation-dom-hem","affiliation-blood-center","affiliation-medicine","database-category-circulatory-system-health-and-disorders","expert-year-287","odd"],"acf":[],"yoast_head":"\nYohei Hisada, PhD | UNC Expertscape-ranked Faculty<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/yohei-hisada-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Yohei Hisada, PhD | UNC Expertscape-ranked Faculty\" \/>\n<meta property=\"og:description\" content=\"My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. 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