{"id":4435,"date":"2024-02-08T13:10:28","date_gmt":"2024-02-08T18:10:28","guid":{"rendered":"https:\/\/www.med.unc.edu\/oor\/experts\/?post_type=faculty-expert&#038;p=4435"},"modified":"2024-07-23T22:09:58","modified_gmt":"2024-07-24T02:09:58","slug":"benjamin-d-philpot-phd","status":"publish","type":"faculty-expert","link":"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/benjamin-d-philpot-phd\/","title":{"rendered":"Benjamin D. Philpot, PhD"},"content":{"rendered":"<p><u>Understanding the molecular, cellular, and circuit-level basis for the pathophysiology underlying monogenic neurodevelopmental disorders<\/u>.\u00a0 A number of neurodevelopmental disorders are caused by mutations in different, seemingly unrelated, genes (e.g. \u2013\u00a0<em>UBE3A and TCF4<\/em>).\u00a0 However, similar phenotypic manifestations suggest that these disorders share underlying cellular phenotypes, or give rise to perturbances that converge pathophysiologically at the circuit level. We employ an array of modern scientific approaches to understand the pathophysiology underlying monogenic neurodevelopmental disorders, and leverage the knowledge gained from these approaches to develop gene therapies and novel drug treatments.<\/p>\n<p><u>Identification and validation of novel therapeutics for the treatment of monogenic neurodevelopmental disorders<\/u>. \u00a0My lab is passionate about identifying novel treatments for monogenic neurodevelopmental disorders such as Angelman, Pitt-Hopkins, and Dup15q syndromes. We focus on strategies to restore or normalize gene expression, through gene therapy and the development of small molecule compounds. My lab has optimized a\u00a0<strong>high-throughput approach for screening small molecules in primary neurons<\/strong>, which have many properties that are not mirrored in dividing cell types.<\/p>\n","protected":false},"featured_media":4436,"template":"","meta":{"_acf_changed":false},"affiliation":[20,35],"database-category":[290],"expert-year":[287],"class_list":["post-4435","faculty-expert","type-faculty-expert","status-publish","has-post-thumbnail","hentry","affiliation-cellbio","affiliation-neuroscience-center","database-category-neuroscience-and-psychiatric-disorders","expert-year-287","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Benjamin D. Philpot, PhD | UNC Expertscape-ranked Faculty<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/benjamin-d-philpot-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Benjamin D. Philpot, PhD | UNC Expertscape-ranked Faculty\" \/>\n<meta property=\"og:description\" content=\"Understanding the molecular, cellular, and circuit-level basis for the pathophysiology underlying monogenic neurodevelopmental disorders.\u00a0 A number of neurodevelopmental disorders are caused by mutations in different, seemingly unrelated, genes (e.g. \u2013\u00a0UBE3A and TCF4).\u00a0 However, similar phenotypic manifestations suggest that these disorders share underlying cellular phenotypes, or give rise to perturbances that converge pathophysiologically at the circuit &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/benjamin-d-philpot-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Expert Database\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-24T02:09:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/oor\/experts\/wp-content\/uploads\/sites\/1368\/2024\/02\/DSCF6177-scaled-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1706\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/benjamin-d-philpot-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/oor\/experts\/faculty-expert\/benjamin-d-philpot-phd\/\",\"name\":\"Benjamin D. 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