{"id":6647,"date":"2025-12-19T15:42:36","date_gmt":"2025-12-19T20:42:36","guid":{"rendered":"https:\/\/www.med.unc.edu\/oor\/?p=6647"},"modified":"2025-12-19T15:42:36","modified_gmt":"2025-12-19T20:42:36","slug":"five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/","title":{"rendered":"Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects"},"content":{"rendered":"<p><em>The UNC School of Medicine Office of Research provided pilot funding to five teams for cutting-edge New Approach Methodologies research.<\/em><\/p>\n<p><em>\u00a0<\/em><\/p>\n<p>The School of Medicine Office of Research sponsors an annual pilot program,\u00a0<em>Emerging Challenges in Biomedical Research (ECBR),\u00a0<\/em>that provides support for innovative, early-stage research relevant to external strategic priorities. The fall 2025 round of funding was focused on advancing translational biomedical research through the use or development of New Approach Methodologies\/Non-Animal Models (NAMs) and New Approach Technologies (NATs). Previous ECBR rounds have provided pilot support for Basic Science, Health Equity Research, COVID-19, Zika, Alzheimer\u2019s Disease, Precision Healthcare and Vaping research.<\/p>\n<p>&nbsp;<\/p>\n<p>Five teams received ECBR funding for cutting-edge NAM\/NAT projects. The teams are:<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/unclineberger.org\/directory\/sarah-shelton\/\"><strong>Sarah Shelton, PhD<\/strong><\/a>, assistant professor in the Lampe Joint Department of Biomedical Engineering, with <a href=\"https:\/\/unclineberger.org\/directory\/brian-c-miller\/\"><strong>Brian Miller, MD, PhD,<\/strong><\/a> (Oncology), and <a href=\"https:\/\/unclineberger.org\/directory\/gianpietro-dotti\/\"><strong>Gianpietro Dotti, MD<\/strong><\/a> (Microbiology &amp; Immunology), will develop advanced tissue-on-chip models to improve CAR T cell therapy for solid tumors. Their project, <strong><em>A New Approach Method for the Discovery of Targets to Improve CAR T Cell Therapy<\/em><\/strong>, aims to enhance CAR T cell infiltration into the tumor microenvironment and identify pathways for engineering more effective therapies.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/douglas-cyr-phd\/\"><strong>Douglas M. Cyr, PhD<\/strong><\/a>, professor in the Department of Cell Biology and Physiology, leads the project, <strong><em>The Mechanism for ProSP-CI73T Proteotoxicity in Idiopathic Lung Fibrosis<\/em><\/strong>. Using induced pluripotent stem cell-derived alveolar epithelial cells, the team will uncover how a common surfactant protein mutation disrupts cell homeostasis and drives IPF onset, paving the way for new therapeutic strategies.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/pathology\/directory\/vaziri\/\"><strong>Cyrus Vaziri, PhD<\/strong><\/a>, professor in Pathology &amp; Laboratory Medicine, with <a href=\"https:\/\/unclineberger.org\/directory\/jessica-l-bowser\/\"><strong>Jessica Bowser, PhD<\/strong><\/a> (Pathology), and <a href=\"https:\/\/www.med.unc.edu\/obgyn\/people\/victoria-bae-jump\/\"><strong>Victoria Bae-Jump, MD, PhD<\/strong><\/a> (OBGYN\/Oncology), will investigate metastatic cancer biology in their proposal, <strong><em>Defining Molecular Vulnerabilities of Metastatic Cancer Spheroids Using Non-Animal Models<\/em><\/strong>. By leveraging patient-relevant 3D spheroid systems, the team seeks to identify protein kinase signaling pathways that sustain metastatic spread and reveal actionable targets for therapy.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/microimm\/people\/sarah-rowe-conlon-phd\/\"><strong>Sarah Rowe-Conlon, PhD<\/strong><\/a>, associate professor in Microbiology and Immunology, with collaborators <a href=\"https:\/\/www.med.unc.edu\/medicine\/infdis\/people\/tessa-andermann\/\"><strong>Tessa Andermann, MD, MPH<\/strong><\/a><strong>,<\/strong> (Medicine\/Infectious Diseases), and <a href=\"https:\/\/www.med.unc.edu\/genetics\/directory\/adriana-beltran\/\"><strong>Adriana Beltran, PhD<\/strong><\/a> (Genetics\/HPCC), will create a human liver organoid model to study hypervirulent <em>Klebsiella pneumoniae<\/em>. Their project, <strong><em>Human Liver Organoid Model to Phenotype Hypervirulent Klebsiella pneumoniae Clinical Isolates<\/em><\/strong>, will improve detection of high-risk strains and reduce reliance on animal models for infection research.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/childrensresearch\/directory\/timothy-p-moran-md-phd\/\"><strong>Timothy P. Moran, MD, PhD<\/strong><\/a>, associate professor in Pediatrics, with <a href=\"https:\/\/www.med.unc.edu\/childrensresearch\/directory\/mike-kulis-phd\/\"><strong>Michael Kulis, PhD<\/strong><\/a> (Peds), <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/scott-randell-phd\/\"><strong>Scott Randell, PhD<\/strong><\/a> (Cell Biology &amp; Physiology), <a href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/directory\/phillip-clapp-phd\/\"><strong>Phillip Clapp, PhD<\/strong><\/a> (Cell Biology &amp; Physiology), <a href=\"https:\/\/www.med.unc.edu\/ent\/directory\/adam-j-kimple-md\/\">Adam Kimple, MD, PhD<\/a> (Otolaryngology), will develop human lymphoid organoids to study food allergy immunotherapy. Their proposal, <strong><em>Development of a Human Lymphoid Organoid Model to Study Food Allergy Immunotherapy<\/em><\/strong>, aims to identify Th1-promoting adjuvants that enhance the efficacy of sublingual immunotherapy for peanut allergy.<\/p>\n<p>&nbsp;<\/p>\n<p>More about the ECBR mechanism and other funding provided by the Office of Research\u00a0<a href=\"https:\/\/www.med.unc.edu\/oor\/research\/funding\/\">can be found here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The UNC School of Medicine Office of Research provided pilot funding to five teams for cutting-edge New Approach Methodologies research. \u00a0 The School of Medicine Office of Research sponsors an annual pilot program,\u00a0Emerging Challenges in Biomedical Research (ECBR),\u00a0that provides support for innovative, early-stage research relevant to external strategic priorities. The fall 2025 round of funding &hellip; <a href=\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\" aria-label=\"Read more about Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects\">Read more<\/a><\/p>\n","protected":false},"author":68915,"featured_media":2249,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[155],"tags":[],"class_list":["post-6647","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects - Office of Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects - Office of Research\" \/>\n<meta property=\"og:description\" content=\"The UNC School of Medicine Office of Research provided pilot funding to five teams for cutting-edge New Approach Methodologies research. \u00a0 The School of Medicine Office of Research sponsors an annual pilot program,\u00a0Emerging Challenges in Biomedical Research (ECBR),\u00a0that provides support for innovative, early-stage research relevant to external strategic priorities. The fall 2025 round of funding &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\" \/>\n<meta property=\"og:site_name\" content=\"Office of Research\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-19T20:42:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/oor\/wp-content\/uploads\/sites\/580\/2018\/02\/image.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"181\" \/>\n\t<meta property=\"og:image:height\" content=\"279\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Andrew Mara-Williams\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Andrew Mara-Williams\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\"},\"author\":{\"name\":\"Andrew Mara-Williams\",\"@id\":\"https:\/\/www.med.unc.edu\/oor\/#\/schema\/person\/04aa6ae36ba311b0e3b4a4fd62edf724\"},\"headline\":\"Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects\",\"datePublished\":\"2025-12-19T20:42:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\"},\"wordCount\":486,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/oor\/wp-content\/uploads\/sites\/580\/2018\/02\/image.jpeg\",\"articleSection\":[\"Featured\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\",\"url\":\"https:\/\/www.med.unc.edu\/oor\/five-teams-receive-ecbr-grants-for-new-approach-methodologies-research-pilot-projects\/\",\"name\":\"Five Teams Receive ECBR Grants for New Approach Methodologies Research Pilot Projects - 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