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Ophthalmology Clinical Trials (Updated 1/23/2020)

Contact Eliza Dubose, MPH at (984) 974-2057 or Sandy Barnhart, MPH at (919) 843-0076 for details regarding clinical trials in the UNC Department of Ophthalmology.

 

CORNEA CLINICAL TRIALS – Ongoing Recruitment

Zoster Burden of Eye Disease/GSK (PI: Gower)

This is an observational, public health study in partnership with Rutgers University for patients with new or recurring herpes zoster.

 

GLAUCOMA CLINICAL TRIALS – Ongoing Recruitment

HSC-MS-15-1053 – The AGS Second Aqueous Shunt Implant vs. TransScleral Cyclophotocoagulation Treatment Study (ASSISTS) (PI: Fleischman)

Patients who have undergone previous glaucoma surgery, and require additional surgery.  The study will last for five years (follow-up will be the same as your standard of care visits).

 

NEURO-OPHTHALMOLOGY CLINICAL TRIALS – Ongoing Recruitment

None currently

 

OCULOPLASTICS CLINICAL TRIALS – Ongoing Recruitment

None currently

 

PEDIATRIC CLINICAL TRIALS – Ongoing Recruitment

Idiopathic Bilateral Cataracts/ Retrophin CTX Study (PI: Whitfield)

This is a study looking at the relationship between idiopathic bilateral cataracts and the diagnosis of CTX.  Patients will be identified via chart review (or referral), and will have some labs done to test for the presence of CTX.  Study consists of one visit.

Pediatric Eye Disease Investigator Group (PEDIG) (PI: Whitfield)

  1. ATS20: Binocular Dig Rush Game Treatment for Amblyopia

This is a study for children ages 4 to 7 with amblyopia.  Subjects will be randomly assigned to either observation or to play a computer game 1 hour per day for at least 5 days a week.  The study will last for 16 weeks.  Those assigned to observation will have the option to switch to the computer game group after 8 weeks.

 

Pediatric Myopia/Sydnexis STAAR Study (PI: Whitfield)

This is a 4 year study testing low dose atropine to prevent progression of pediatric myopia.  Patients must be between the ages of 3 and 14, and meet certain vision criteria.

 

RETINA CLINICAL TRIALS – Ongoing Recruitment

Diabetic Retinopathy Clinical Research Network (PI: Ulrich)

None Currently

 

UPCOMING STUDIES – NOT YET RECRUITING

 

Pediatric Eye Disease Investigator Group (PEDIG) (PI: Grace)

None Currently

 

STUDIES IN PROGRESS (NO LONGER ENROLLING):

Diabetic Retinopathy Clinical Research Network (PI: Ulrich)

DRCR W: Intravitreous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk

This is a 4 year study looking at patients with Severe Non-Proliferative Diabetic Retinopathy (Severe NPDR).  Patients will be randomized to either study drug or sham injections to see if study drug injections help to prevent worsening of NPDR.  Participants will have best-corrected vision of 20/25 or better and not have any active diabetic macular edema, or any treatment for diabetic macular edema within the past year (including laser and injections).

 

DRCR AA: Peripheral DR Lesions on Ultrawide-field Fundus Images and Risk of Diabetic Retinopathy

Worsening Over Time

This is a 4 year study that will be obtaining ultrawide imaging on patients with diabetic retinopathy.  Patients will be followed annually for the study.