{"id":10204,"date":"2024-11-08T14:47:43","date_gmt":"2024-11-08T19:47:43","guid":{"rendered":"https:\/\/www.med.unc.edu\/ophth\/?p=10204"},"modified":"2024-11-10T12:57:27","modified_gmt":"2024-11-10T17:57:27","slug":"jackie-bower-oxford-harrington-rare-disease","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/ophth\/2024\/11\/jackie-bower-oxford-harrington-rare-disease\/","title":{"rendered":"Jackie Bower Named One of 10 Inaugural Oxford-Harrington Rare Disease Centre (OHC) Scholars"},"content":{"rendered":"

\"\"<\/p>\n

UNC Ophthalmology congratulates Research Assistant Professor Jackie Bower, PhD<\/b>, for being named one of 10 scientists worldwide to the inaugural class of Oxford-Harrington Rare Disease Centre (OHC) Scholar Award recipients. The OHC is a trans-Atlantic partnership between University of Oxford (Oxford, UK) and the Harrington Discovery Institute at University Hospitals (Cleveland, Ohio). The Centre brings together world-leading researchers, therapeutics development experts and industry backers to advance toward market breakthrough therapeutic solutions for treating neurologic, oncologic, and metabolic disease and rare\/ultra-rare diseases.<\/p>\n

\n

Dr. Bower is an established leader of large-scale sponsored studies to identify and develop therapeutic approaches to treating uveal melanoma. Her area of translational research focus is studying ocular tumorigenesis mechanisms and DNA-damage related causes of ocular pathogenesis. The OHC awards each Oxford-Harrington Rare Disease Centre (OHC) scholar $100K to support therapeutics-driven rare disease projects in their area of expertise. Dr. Bower will apply her OHC award funding to support her lab’s study entitled: “Novel viral gene therapy to treat lethal rare eye tumors.”\u00a0 This study advances the aims of her lab’s investigative work in developing therapeutic solutions to treat uveal melanoma.<\/p>\n

Dr. Bower noted: \u201cMost cancers are unsuitable for a traditional gene therapy-based treatment approach, but uveal melanoma is somewhat of a genetic anomaly in that respect. About 90% harbor a single mutation that is required for tumor cell survival.\u00a0 My team\u2019s approach is based on using a non-pathogenic virus [adeno-associated virus, AAV] to inhibit the function of that survival protein, presenting a unique opportunity to use gene therapy for a rare tumor type.”<\/p>\n

To read the Oxford-Harrington Centre news announcement on the selection of the Inaugural 2024 Rare Disease Scholar Award class, click HERE<\/strong><\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

UNC Ophthalmology congratulates Research Assistant Professor Jackie Bower, PhD, for being named one of 10 scientists worldwide to the inaugural class of Oxford-Harrington Rare Disease Centre (OHC) Scholar Award recipients. The OHC is a trans-Atlantic partnership between University of Oxford (Oxford, UK) and the Harrington Discovery Institute at University Hospitals (Cleveland, Ohio). The Centre brings … Read more<\/a><\/p>\n","protected":false},"author":17488,"featured_media":10230,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-10204","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nJackie Bower Named One of 10 Inaugural Oxford-Harrington Rare Disease Centre (OHC) Scholars | Department of Ophthalmology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/ophth\/2024\/11\/jackie-bower-oxford-harrington-rare-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jackie Bower Named One of 10 Inaugural Oxford-Harrington Rare Disease Centre (OHC) Scholars | Department of Ophthalmology\" \/>\n<meta property=\"og:description\" content=\"UNC Ophthalmology congratulates Research Assistant Professor Jackie Bower, PhD, for being named one of 10 scientists worldwide to the inaugural class of Oxford-Harrington Rare Disease Centre (OHC) Scholar Award recipients. 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