{"id":2307,"date":"2025-03-15T19:11:06","date_gmt":"2025-03-15T23:11:06","guid":{"rendered":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/?page_id=2307"},"modified":"2026-01-28T11:33:47","modified_gmt":"2026-01-28T16:33:47","slug":"publication","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/publication\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2404\" src=\"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-content\/uploads\/sites\/1441\/2025\/04\/Weixin-Image_20250406141438-232x300.jpg\" alt=\"Superior and inferior image of computational tendon model including subtendons\" width=\"185\" height=\"259\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2400\" src=\"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-content\/uploads\/sites\/1441\/2025\/04\/Picture5-268x300.png\" alt=\"Fiber tractography of three compartments of soleus muscle from DTI\" width=\"211\" height=\"250\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2428\" src=\"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-content\/uploads\/sites\/1441\/2025\/04\/Picture9-281x300.png\" alt=\"Muscle volume profiles of 15 NCAA D1 sprinters\" width=\"223\" height=\"246\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2429\" src=\"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-content\/uploads\/sites\/1441\/2025\/04\/Picture10-300x300.png\" alt=\"Muscle volume profile from 10 adolescent cerebral palsy patients and 2 adolescent controls\" width=\"237\" height=\"246\" \/> \u00a0\u00a0\u00a0 <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2432\" src=\"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-content\/uploads\/sites\/1441\/2025\/04\/DTI_calf-258x300.png\" alt=\"Fiber tractography of the muscle in the lower leg from DTI\" width=\"199\" height=\"252\" \/><\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/journals\/sports-and-active-living\/articles\/10.3389\/fspor.2020.00070\/full\" target=\"_blank\" rel=\"noopener\">(Handsfield et al., 2020)<\/a> \u00a0 \u00a0 \u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/journals.plos.org\/plosone\/article\/file?id=10.1371\/journal.pone.0205944&amp;type=printable\" target=\"_blank\" rel=\"noopener\">(Sahrmann et al., 2019)<\/a> \u00a0 \u00a0 \u00a0\u00a0\u00a0\u00a0 <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.12723\" target=\"_blank\" rel=\"noopener\">(Handsfield et al., 2017)<\/a> \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0 \u00a0\u00a0 <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.24972\" target=\"_blank\" rel=\"noopener\">(Handsfield et al., 2016)<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0 <a href=\"https:\/\/doi.org\/10.6084\/m9.figshare.28773770.v1\" target=\"_blank\" rel=\"noopener\">(Handsfield, 2025)<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Bin Ghouth, S., Besier, T. &amp; Handsfield, G. <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10439-025-03866-0\" target=\"_blank\" rel=\"noopener\">Statistical Shape and Fibre Orientation Model for Muscle Architecture Characterisation of the Medial Gastrocnemius<\/a>.<em> Ann Biomed Eng<\/em> (2025).<\/p>\n<p>Perera, M. R., Condron, P., &amp; Handsfield, G. (2025). <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/21681163.2025.2504445?scroll=top&amp;needAccess=true\" target=\"_blank\" rel=\"noopener\">An in vivo imaging study of fascia thickness and muscle volume in the lower limb of healthy adult humans<\/a>.\u00a0<i>Computer Methods in Biomechanics and Biomedical Engineering: Imaging &amp; Visualization<\/i>,\u00a0<i>13<\/i>(1).<\/p>\n<p>Perera, M. R., Bydder, G. M., Holdsworth, S. J., &amp; Handsfield, GG (2025). <a href=\"https:\/\/www.mdpi.com\/2313-433X\/11\/2\/43\" target=\"_blank\" rel=\"noopener\">Imaging and Image Processing Techniques for High-Resolution Visualization of Connective Tissue with MRI: Application to Fascia, Aponeurosis, and Tendon<\/a>.\u00a0<i data-ogsc=\"\">Journal of Imaging<\/i>, 11(2), 43.<\/p>\n<p>Perera, M.R., Su, P., Holdsworth, S. &amp; Handsfield, GG (2025) <a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12891-024-08254-8\" target=\"_blank\" rel=\"noopener\">Changes to muscle and fascia tissue after eighteen days of ankle immobilization post-ankle sprain injury: an MRI case study<\/a>. <i data-ogsc=\"\">BMC Musculoskelet Disord<\/i>\u00a026, 34<\/p>\n<p>Sahrmann, AS, Vosse, L, Siebert, T, Handsfield, G, and Rohrle, O. (2024) <a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=quJQX0gAAAAJ&amp;sortby=pubdate&amp;citation_for_view=quJQX0gAAAAJ:M05iB0D1s5AC\" target=\"_blank\" rel=\"noopener\">Determination of Muscle Shape Deformations of the Tibialis Anterior during Dynamic Contractions Using 3D Ultrasound<\/a>, <i data-ogsc=\"\">Frontiers in Bioengineering and Biotechnology 12: 1388907<\/i><\/p>\n<p>Cornfeld D, Condron P, Newburn G, McGeown J, Scadeng M, Bydder M, Griffin M, Handsfield G, Perera MR, Melzer T, Holdsworth S. (2024) <a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=quJQX0gAAAAJ&amp;sortby=pubdate&amp;citation_for_view=quJQX0gAAAAJ:ldfaerwXgEUC\" target=\"_blank\" rel=\"noopener\">Ultra-High Contrast MRI: Using Divided Subtracted Inversion Recovery (dSIR) and Divided Echo Subtraction (dES) Sequences to Study the Brain and Musculoskeletal System<\/a> <i data-ogsc=\"\">Bioengineering<\/i>\u00a011(5):441.<\/p>\n<p>Sahrmann, A., Vosse, L., Siebert, T., Handsfield, G., &amp; R\u00f6hrle, O. (2024). <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10237-024-01837-3\" target=\"_blank\" rel=\"noopener\">3D Ultrasound based Determination of Skeletal Muscle Fascicle Orientations<\/a>. <i data-ogsc=\"\">Biomechanics and Modeling in Mechanobiology 23(4): 1263-1276.<\/i><\/p>\n<p>Sahrmann, A. S., Handsfield, G. G., Gizzi, L., Gerlach, J., Verl, A., Besier, T. F., &amp; R\u00f6hrle, O. (2024). <a href=\"https:\/\/ieeexplore.ieee.org\/abstract\/document\/10416373\" target=\"_blank\" rel=\"noopener\">A System for Reproducible 3D Ultrasound Measurements of Skeletal Muscles<\/a>. <i data-ogsc=\"\">IEEE Transactions on Biomedical Engineering<\/i> 71(7): 2022-2032.<\/p>\n<p>Khuu, S, Fernandez, J, Handsfield, GG (2023) <a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1011042\" target=\"_blank\" rel=\"noopener\">Delayed Skeletal Muscle Repair Following Inflammatory Damage in Simulated Agent-Based Models of Muscle Regeneration<\/a> <i data-ogsc=\"\">PLoS Computational Biology\u00a0<\/i>19(4): e1011042.<\/p>\n<p>Handsfield, GG, Williams, S, Khuu, S, Lichtwark,G, and Stott, NS (2022) <a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12891-022-05110-5\" target=\"_blank\" rel=\"noopener\">Muscle Architecture, Growth, and Biological Remodelling in Cerebral Palsy<\/a> <i data-ogsc=\"\">BMC Musculoskeletal Disorders\u00a0<\/i>23(1): 1-17.<\/p>\n<p>Bin Ghouth, S, Williams, S, Reid, SL, Besier, TF, Handsfield, GG (2022) <a href=\"https:\/\/www.nature.com\/articles\/s41598-022-11611-z\" target=\"_blank\" rel=\"noopener\">A Statistical Shape Model of Soleus Muscle Morphology in Spastic Cerebral Palsy<\/a> <em>Nature <\/em><i data-ogsc=\"\">Scientific Reports\u00a0<\/i>12(1): 1-10.<\/p>\n<p>Varvik, J., Besier, T.F., and Handsfield, G.G. (2021) <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/cnm.3521\" target=\"_blank\" rel=\"noopener\">CFD Simulations for 3D Muscle Fiber Architecture in Finite Element Analysis: Comparisons between CFD and Diffusion Tensor Imaging<\/a> <i data-ogsc=\"\">International Journal for Numerical Methods in Biomedical Engineering\u00a0<\/i>e3521-e3521<\/p>\n<p>Khuu, S, Fernandez, J, Handsfield, GG (2021) <a href=\"https:\/\/www.frontiersin.org\/journals\/bioengineering-and-biotechnology\/articles\/10.3389\/fbioe.2021.689714\/full\" target=\"_blank\" rel=\"noopener\">A Coupled Mechanobiological Model of Muscle Regeneration in Cerebral Palsy<\/a> <i data-ogsc=\"\">Frontiers in Bioengineering and Biotechnology\u00a0<\/i>9: 689714.<\/p>\n<p>Choisne, J., Fourrier, N., Handsfield, G., Signal, N., Taylor, D., Wilson, N., Stott, S., Besier, T. (2020) <a href=\"https:\/\/www.mdpi.com\/2077-0383\/9\/5\/1432\" target=\"_blank\" rel=\"noopener\">An unsupervised data-driven model to classify gait patterns in children with cerebral palsy<\/a> <i data-ogsc=\"\">Journal of Clinical Medicine<\/i> 9(5):1432.<\/p>\n<p>Yeung, S., Fernandez, J.W., Handsfield, G.G., Walker, C., Besier, T., Zhang, J. (2020) <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10237-019-01243-0\" target=\"_blank\" rel=\"noopener\">Rapid muscle volume prediction using anthropometric measurements and population derived statistical models<\/a> <i data-ogsc=\"\">Biomechanics and Modeling in Mechanobiology\u00a0<\/i>19(4): 1239-1249.<\/p>\n<p>Handsfield, GG, Greiner, J, Madl, J, Rog-Zielinska, E, Holville, E, Vanwanseele, B, and Shim, V (2020) <a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=quJQX0gAAAAJ&amp;cstart=20&amp;pagesize=80&amp;sortby=pubdate&amp;citation_for_view=quJQX0gAAAAJ:RHpTSmoSYBkC\" target=\"_blank\" rel=\"noopener\">Achilles Subtendon Structure and Behavior as Evidenced from Tendon Imaging and Computational Modeling<\/a> <i data-ogsc=\"\">Frontiers in Sports and Active Living\u00a0<\/i>2: 70.<\/p>\n<p>Sahrmann, A.S., Stott, N.S., Besier, T.F., Fernandez, J.W., Handsfield, G.G. (2019) <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0205944\" target=\"_blank\" rel=\"noopener\">Soleus Muscle Weakness in Cerebral Palsy: Muscle Architecture Revealed with Diffusion Tensor Imaging<\/a> <i data-ogsc=\"\">PLoS One<\/i>\u00a014(2): e0205944.<\/p>\n<p>Handsfield, GG, Knaus, K, Fiorentino, N, Meyer, C, Hart, J &amp; Blemker, SS (2017). <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/sms.12723\" target=\"_blank\" rel=\"noopener\">Adding Muscle Where You Need It: Non-uniform Hypertrophy Patterns in Elite Sprinters<\/a> <i data-ogsc=\"\">Scandinavian Journal of Medicine and Science in Sports,\u00a0<\/i>27(10): 1050-1060.<\/p>\n<p>Handsfield, G. G., Inouye, J.M., Slane, L.C., Thelen, D.G., Miller, G.W., &amp; Blemker, S. S. (2017). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021929016312416\" target=\"_blank\" rel=\"noopener\">A 3D Model of the Achilles Tendon to Determine the Mechanisms Underlying Nonuniform Tendon Displacements<\/a> <i data-ogsc=\"\">J Biomechanics\u00a0<\/i>51: 17-25<\/p>\n<p>Handsfield, G.G., Bolsterlee, B., Inouye, J.I., Besier, T.F., and Fernandez, J. (2017) <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10237-017-0923-5\" target=\"_blank\" rel=\"noopener\">Determining skeletal muscle architecture with Laplacian simulations: A validation with diffusion tensor imaging<\/a> <i data-ogsc=\"\">Biomechanics and Modeling in Mechanobiology 16: 1845-1855.<\/i><\/p>\n<p>Norte, GE, Knaus, KR, Kuenze, C, Handsfield, GG, Meyer, C, Blemker, SS, and Hart, JM (2017) <a href=\"https:\/\/journals.humankinetics.com\/view\/journals\/jsr\/27\/3\/article-p201.xml\" target=\"_blank\" rel=\"noopener\">MRI-based assessment of lower extremity muscle volumes in patients before and after ACL reconstruction<\/a>, <i data-ogsc=\"\">Journal of Sport Rehabilitation\u00a0<\/i>27(3): 201-212.<\/p>\n<p>Handsfield, G.G., Meyer, C.H., Hart, J.M., Abel, M.F. and Blemker, S.S. (2016) <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mus.24972\" target=\"_blank\" rel=\"noopener\">Heterogeneity of Muscle Sizes in the Lower Limbs of Children with Cerebral Palsy<\/a>, <i data-ogsc=\"\">Muscle and Nerve\u00a0<\/i>53(6): 933-945.<\/p>\n<p>Feger, M.A., Snell, S., Handsfield, G.G., Blemker, S.S., Wombacher, E., Fry, R., Hart, J.M., Saliba, S.A., Park, J.S., Hertel, J. (2016) <a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/2325967116653719\" target=\"_blank\" rel=\"noopener\">Diminished foot and ankle muscle volumes in young adults with chronic ankle instability<\/a>, <i data-ogsc=\"\">Orthopaedic Journal of Sports Medicine\u00a0<\/i>4(6): 2325967116653719.<\/p>\n<p>Handsfield, G. G., Slane, L.C., Screen, H.R.C. (2016) <a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=quJQX0gAAAAJ&amp;cstart=20&amp;pagesize=80&amp;sortby=pubdate&amp;citation_for_view=quJQX0gAAAAJ:Se3iqnhoufwC\" target=\"_blank\" rel=\"noopener\">Nomenclature of the Tendon Hierarchy: An Overview of Inconsistent Terminology and a Proposed Size-Based Naming Scheme with Terminology for Multi-Muscle Tendons<\/a>, <i data-ogsc=\"\">Journal of Biomechanics\u00a0<\/i>49(13): 3122-3124.<\/p>\n<p>Handsfield, G.G., Meyer, C.H., Hart, J.M., Abel, M.F. and Blemker, S.S. (2014) <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021929013006234\" target=\"_blank\" rel=\"noopener\">Relationships of 35 Lower Limb Muscles to Height and Mass Quantified Using MRI<\/a>, <i data-ogsc=\"\">Journal of Biomechanics<\/i>\u00a047(3): 631-638.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u00a0\u00a0\u00a0 (Handsfield et al., 2020) \u00a0 \u00a0 \u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0 (Sahrmann et al., 2019) \u00a0 \u00a0 \u00a0\u00a0\u00a0\u00a0 (Handsfield et al., 2017) \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0\u00a0 \u00a0 \u00a0\u00a0 (Handsfield et al., 2016) \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0 (Handsfield, 2025) &nbsp; Bin Ghouth, S., Besier, T. &amp; Handsfield, G. Statistical Shape and Fibre &hellip; <a href=\"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/publication\/\" aria-label=\"Read more about Publications\">Read more<\/a><\/p>\n","protected":false},"author":120624,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2307","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/pages\/2307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/users\/120624"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/comments?post=2307"}],"version-history":[{"count":14,"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/pages\/2307\/revisions"}],"predecessor-version":[{"id":2558,"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/pages\/2307\/revisions\/2558"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/ortho\/mobioslab\/wp-json\/wp\/v2\/media?parent=2307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}