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X-WR-CALDESC:Events for Department of Orthopaedics
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DTSTART;TZID=America/New_York:20251023T120000
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SUMMARY:OrthoRaMS Seminar Series - Karen Kruger
DESCRIPTION:Join us for the fall OrthoRaMS Seminar series featuring Karen Kruger\, PhD presenting “From Childhood to Adulthood” Innovative Tools for Evaluating Foot and Ankle Deformities” on October 23\, 2025 from 12:00 – 1:00 PM. \nClinical gait analysis provides an objective evaluation of walking\npatterns in children with orthopaedic and neurologic conditions\,\nmost commonly for preoperative planning in cerebral palsy. This\nanalysis combines motion capture\, force plate data\, physical\nexam\, electromyography\, x-rays\, and advanced modeling. Foot\nand ankle analysis is particularly challenging in this population\,\nespecially given the limitations of conventional marker-based\nmotion capture and x-rays. This talk will focus on novel imaging\nmodalities we are using to improve diagnoses of foot deformities.\nThis talk presents two complementary projects that address\nthese gaps. First\, we are using weightbearing computed tomogra-\nphy (WBCT)\, a technology that provides 3D imaging with similar\nradiation exposure than conventional radiographs to define\nstructural predictors of symptom progression and improve early\ndiagnosis and treatment planning. Second\, we are developing\nmethods for use of biplane fluoroscopy for evaluating hindfoot\nkinematics in adults with cerebral palsy. Together\, these efforts\naim to bridge research from childhood through adulthood\,\nadvancing imaging and motion analysis to guide clinical deci-\nsion-making and improve lifelong outcomes. \n  \nAbout Dr. Kruger: \nDr. Karen Kruger is a research associate professor at Marquette\nUniversity and Scientific Staff at Shriners Children. She completed\nher BS in Mechanical Engineering at Michigan Technological Uni-\nversity and PhD in Biomedical Engineering at the University of\nlowa with a concentration in orthopaedic biomechanics. Her\ncurrent work focuses on using motion analysis and imaging to\nimprove diagnosis and treatment of foot disorders\, with a focus\non improving understanding during growth and development. \n  \nView the seminar flier.
URL:https://www.med.unc.edu/ortho/event/orthorams-seminar-series-karen-kruger/
LOCATION:Dickson Conference Room\, 3200 Thurston Building\, 104 Manning Drive\, Chapel Hill\, NC\, 27599\, United States
CATEGORIES:Ortho RAMS
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20251023T120000
DTEND;TZID=America/New_York:20251023T130000
DTSTAMP:20260427T214123
CREATED:20251009T201050Z
LAST-MODIFIED:20251009T201051Z
UID:10000024-1761220800-1761224400@www.med.unc.edu
SUMMARY:OrthoRaMS Seminar Series - Karen Kruger\, PhD
DESCRIPTION:Karen Kruger\, PhD is presenting\, “From Childhood to Adulthood: Innovative Tools for Evaluating Foot and Ankle Deformities” on Thursday\, October 23rd from 12 – 1 PM in the Dickson Conference Room of the Thurston Building (3200 Thurston Building). \nClinical gait analysis provides an objective evaluation of walking patterns in children with orthopaedic and neurologic conditions\, most commonly for preoperative planning in cerebral palsy. This analysis combines motion capture\, force plate data\, physical exam\, electromyography\, x-rays\, and advanced modeling. Foot and ankle analysis is particularly challenging in this population\, especially given the limitations of conventional marker-based motion capture and x-rays. This talk will focus on novel imaging modalities we are using to improve diagnoses of foot deformities.\nThis talk presents two complementary projects that address these gaps. First\, we are using weightbearing computed tomography (WBCT)\, a technology that provides 3D imaging with similar tradiation exposure than conventional radiographs to define structural predictors of symptom progression and improve early diagnosis and treatment planning. Second\, we are developing methods for use of biplane fluoroscopy for evaluating hindfoot kinematics in adults with cerebral palsy. Together\, these efforts aim to bridge research from childhood through adulthood\, advancing imaging and motion analysis to guide clinical decision-making and improve lifelong outcomes. \nAbout Dr. Kruger\nDr. Karen Kruger is a research associate professor at Marquette University and Scientific Staff at Shriners Children. She completed her BS in Mechanical Engineering at Michigan Technological University and PhD in Biomedical Engineering at the University of Ilowa with a concentration in orthopaedic biomechanics. Her current work focuses on using motion analysis and imaging to improve diagnosis and treatment of foot disorders\, with a focus on improving understanding during growth and development. \nSee the event flier here.
URL:https://www.med.unc.edu/ortho/event/orthorams-seminar-series-karen-kruger-phd/
LOCATION:Dickson Conference Room\, 3200 Thurston Building\, 104 Manning Drive\, Chapel Hill\, NC\, 27599\, United States
CATEGORIES:Ortho RAMS
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241205T130000
DTEND;TZID=America/New_York:20241205T140000
DTSTAMP:20260427T214123
CREATED:20241107T161800Z
LAST-MODIFIED:20241120T183830Z
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SUMMARY:OrthoRaMS - Gurpreet Baht\, PhD
DESCRIPTION:“ApoE: A new target to improve aged bone fracture healing” \nPresented by Gurpreet S. Baht\, PhD (Duke University) \nJoin us for our next seminar in the OrthRaMS Seminar Series on December 5th\, 2024 from 1-2 PM. \nBone fracture healing is impaired with advanced age however the underlying mechanism is unknown. Our previous work indicated circulating apolipoprotein E (ApoE) as an aging factor\, increasing with age and impairing bone regeneration. Since the liver is the primary source of circulating ApoE\, we deleted hepatic expression of ApoE using Albumin-Cre;ApoEfl/fl (∆ApoE) mice and investigated tibial fracture healing in aged (24-month-old) mice. ∆ApoE mice displayed 95% reduction in circulating ApoE; micro-CT and histological analysis demonstrated increased bone deposition in 21-day fracture calluses. ApoE-treatment of aged BMSCs in tissue culture models inhibited osteoblast differentiation. Subsequent RNA sequencing of these cultures indicated that the Wnt/β-catenin was the primary target of this ApoE-based inhibition. Indeed\, A p o treatment had no inhibitory effect on cultures in which β-catenin levels were stabilized. We determined Lp4\, whose expression was required in ApoE-based inhibition of Wnt/ß-catenin signaling and osteoblast differentiation\, to be the osteoblast cell surface receptor to ApoE. Importantly\, we validated this ApoE-Lrp4-Wnt/β-catenin molecular mechanism in human osteoblast differentiation. Finally\, we identified an ApoE-neutralizing antibody (NAb) able to lower levels of circulating ApoE when delivered systemically. Aged\, wildtype mice underwent fracture surgery and were treated with NAb 3 days post injury. Their fracture calluses contained 35% more bone tissue\, evidencing improved aged fracture healing. Our work here identifies novel cross-organ communication\, liver-to-bone cross-talk via hepatic ApoE expression. Using this information\, we have developed a noninvasive\, translatable therapeutic intervention for bone regeneration and provides a translatable therapeutic intervention. \n  \nBaht_OrthoRaMS_flyer
URL:https://www.med.unc.edu/ortho/event/orthorams-gurpreet-baht-phd/
LOCATION:Dickson Conference Room\, 3200 Thurston Building\, 104 Manning Drive\, Chapel Hill\, NC\, 27599\, United States
CATEGORIES:Ortho RAMS
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241114T130000
DTEND;TZID=America/New_York:20241114T140000
DTSTAMP:20260427T214123
CREATED:20241014T131436Z
LAST-MODIFIED:20241106T134514Z
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SUMMARY:OrthoRaMS - Shadow Huang
DESCRIPTION:“Mechanics and Computational Modeling of Biological Tissues” \nPresented by Shadow Huang\, PhD (NC State University) \nThe mechanics of biological tissues\, including both soft and hard tissues\, si a multidisciplinary research area. There si a growing recognition that mathematical modeling plays a crucial role ni understanding and predicting tissue growth and remodeling. These models can guide the identification and interpretation of insightful experiments and enable efficient exploration of the implications of various hypotheses. nI my research group at NC State University\, we employ a combination of experimental\, microstructural\, continuum mechanical\, and com- putational methods to gain a deeper understanding of the relationships among tissue structure\, properties\, and functions. I wil present examples from cardio- vascular tissues\, such as venous tissue\, and musculoskeletal tissues\, specifically tendon-bone insertion. The in-silico models we construct in this research are verified and refined by comparing them to our in-situ biaxial mechanical testing results\, making them valuable translational tools for accurately predicting the material behavior of biological tissues. \nIf you have questions or would like more information\, contact Dr. Geoffrey Handsfield via email. \nOrthoRaMS - Shadow Huang
URL:https://www.med.unc.edu/ortho/event/orthorams-shadow-huang/
LOCATION:Dickson Conference Room\, 3200 Thurston Building\, 104 Manning Drive\, Chapel Hill\, NC\, 27599\, United States
CATEGORIES:Ortho RAMS
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