{"id":6501,"date":"2024-11-07T11:18:00","date_gmt":"2024-11-07T16:18:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/ortho\/?post_type=tribe_events&#038;p=6501"},"modified":"2024-11-20T13:38:30","modified_gmt":"2024-11-20T18:38:30","slug":"orthorams-gurpreet-baht-phd","status":"publish","type":"tribe_events","link":"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/","title":{"rendered":"OrthoRaMS &#8211; Gurpreet Baht, PhD"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-6502 aligncenter\" src=\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1.jpg\" alt=\"Image of Gurpreet Baht\" width=\"209\" height=\"209\" srcset=\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1.jpg 300w, https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1-150x150.jpg 150w\" sizes=\"auto, (max-width: 209px) 100vw, 209px\" \/><\/p>\n<p style=\"text-align: center\"><strong>&#8220;ApoE: A new target to improve aged bone fracture healing&#8221;<\/strong><\/p>\n<p style=\"text-align: center\"><strong>Presented by <a href=\"https:\/\/ortho.duke.edu\/personnel\/gurpreet-s-baht-phd\">Gurpreet S. Baht<\/a>, PhD (Duke University)<\/strong><\/p>\n<p>Join us for our next seminar in the OrthRaMS Seminar Series on December 5th, 2024 from 1-2 PM.<\/p>\n<p>Bone fracture healing is impaired with advanced age however the underlying mechanism is unknown. Our previous work indicated circulating apolipoprotein E (ApoE) as an aging factor, increasing with age and impairing bone regeneration. Since the liver is the primary source of circulating ApoE, we deleted hepatic expression of ApoE using Albumin-Cre;ApoEfl\/fl (\u2206ApoE) mice and investigated tibial fracture healing in aged (24-month-old) mice. \u2206ApoE mice displayed 95% reduction in circulating ApoE; micro-CT and histological analysis demonstrated increased bone deposition in 21-day fracture calluses. ApoE-treatment of aged BMSCs in tissue culture models inhibited osteoblast differentiation. Subsequent RNA sequencing of these cultures indicated that the Wnt\/\u03b2-catenin was the primary target of this ApoE-based inhibition. Indeed, A p o treatment had no inhibitory effect on cultures in which \u03b2-catenin levels were stabilized. We determined Lp4, whose expression was required in ApoE-based inhibition of Wnt\/\u00df-catenin signaling and osteoblast differentiation, to be the osteoblast cell surface receptor to ApoE. Importantly, we validated this ApoE-Lrp4-Wnt\/\u03b2-catenin molecular mechanism in human osteoblast differentiation. Finally, we identified an ApoE-neutralizing antibody (NAb) able to lower levels of circulating ApoE when delivered systemically. Aged, wildtype mice underwent fracture surgery and were treated with NAb 3 days post injury. Their fracture calluses contained 35% more bone tissue, evidencing improved aged fracture healing. Our work here identifies novel cross-organ communication, liver-to-bone cross-talk via hepatic ApoE expression. Using this information, we have developed a noninvasive, translatable therapeutic intervention for bone regeneration and provides a translatable therapeutic intervention.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/Baht_OrthoRaMS_flyer.pdf\">Baht_OrthoRaMS_flyer<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;ApoE: A new target to improve aged bone fracture healing&#8221; Presented by Gurpreet S. Baht, PhD (Duke University) Join us for our next seminar in the OrthRaMS Seminar Series on December 5th, 2024 from 1-2 PM. Bone fracture healing is impaired with advanced age however the underlying mechanism is unknown. Our previous work indicated circulating &hellip; <a href=\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/\" aria-label=\"Read more about OrthoRaMS &#8211; Gurpreet Baht, PhD\">Read more<\/a><\/p>\n","protected":false},"author":115151,"featured_media":0,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","_links_to":"","_links_to_target":""},"tags":[],"tribe_events_cat":[32],"class_list":["post-6501","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-ortho-rams","cat_ortho-rams","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>OrthoRaMS - Gurpreet Baht, PhD | Department of Orthopaedics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OrthoRaMS - Gurpreet Baht, PhD | Department of Orthopaedics\" \/>\n<meta property=\"og:description\" content=\"&#8220;ApoE: A new target to improve aged bone fracture healing&#8221; Presented by Gurpreet S. Baht, PhD (Duke University) Join us for our next seminar in the OrthRaMS Seminar Series on December 5th, 2024 from 1-2 PM. Bone fracture healing is impaired with advanced age however the underlying mechanism is unknown. Our previous work indicated circulating &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Orthopaedics\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCOrthopedics\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-20T18:38:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/\",\"name\":\"OrthoRaMS - Gurpreet Baht, PhD | Department of Orthopaedics\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1.jpg\",\"datePublished\":\"2024-11-07T16:18:00+00:00\",\"dateModified\":\"2024-11-20T18:38:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2024\/11\/baht_burpreet_1.jpg\",\"width\":300,\"height\":300,\"caption\":\"Image of Gurpreet Baht\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/ortho\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Events\",\"item\":\"https:\/\/www.med.unc.edu\/ortho\/events\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"OrthoRaMS &#8211; Gurpreet Baht, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/ortho\/\",\"name\":\"Department of Orthopaedics\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/ortho\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/#organization\",\"name\":\"UNC Department of Orthopaedics\",\"url\":\"https:\/\/www.med.unc.edu\/ortho\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2019\/03\/Orthopaedics_logo_rgb_h.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/ortho\/wp-content\/uploads\/sites\/406\/2019\/03\/Orthopaedics_logo_rgb_h.png\",\"width\":982,\"height\":151,\"caption\":\"UNC Department of Orthopaedics\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/ortho\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/UNCOrthopedics\/\",\"https:\/\/www.youtube.com\/user\/uncorthopaedics\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"OrthoRaMS - Gurpreet Baht, PhD | Department of Orthopaedics","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/ortho\/event\/orthorams-gurpreet-baht-phd\/","og_locale":"en_US","og_type":"article","og_title":"OrthoRaMS - Gurpreet Baht, PhD | Department of Orthopaedics","og_description":"&#8220;ApoE: A new target to improve aged bone fracture healing&#8221; Presented by Gurpreet S. 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