Research Interests
Molecular and functional roles of RhoGaps in hypertension and metabolism regulation
Selected Publications
Bai X, Mangum K, Kakoki M, Smithies O, Mack CP, Taylor JM. GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure. Small GTPases. 2017 Nov 3:1-10. doi: 10.1080/21541248.2017.1375602. [Epub ahead of print] PubMed PMID: 29099324.
Bai X, Mangum KD, Dee RA, Stouffer GA, Lee CR, Oni-Orisan A, Patterson C, Schisler JC, Viera AJ, Taylor JM, Mack CP. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. J Clin Invest. 2017 Feb 1;127(2):670-680. doi: 10.1172/JCI88899. Epub 2017 Jan 23. PubMed PMID: 28112683; PubMed Central PMCID: PMC5272192.
Bai X, Lenhart KC, Bird KE, Suen AA, Rojas M, Kakoki M, Li F, Smithies O, Mack CP, Taylor JM. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nat Commun. 2013;4:2910. doi: 10.1038/ncomms3910. PubMed PMID: 24335996; PubMed Central PMCID: PMC4237314.
Bai X, Margariti A, Hu Y, Sato Y, Zeng L, Ivetic A, Habi O, Mason JC, Wang X, Xu Q. Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2467-74. doi: 10.1161/ATVBAHA.110.215723. Epub 2010 Sep 30. PubMed PMID: 20884873.
Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, Shyy JY, Wang X. Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1485-92. doi: 10.1152/ajpcell.00173.2010. Epub 2010 Sep 29. PubMed PMID: 20881236.
Bai X, Wang X, Xu Q. Endothelial damage and stem cell repair in atherosclerosis. Vascul Pharmacol. 2010 May-Jun;52(5-6):224-9. doi: 10.1016/j.vph.2010.02.001. Epub 2010 Feb 13. Review. PubMed PMID: 20156585.
Wang L, Zheng J, Bai X, Liu B, Liu CJ, Xu Q, Zhu Y, Wang N, Kong W, Wang X. ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries. Circ Res. 2009 Mar 13;104(5):688-98. doi: 10.1161/CIRCRESAHA.108.188425. Epub 2009 Jan 22. PubMed PMID: 19168437.
