My research interests are around immune-mediated glomerular diseases and vasculitis. My current studies focus on defining the immunopathological mechanisms involved in autoimmune glomerulonephritis and vasculitis with particular emphasis on understanding the role of anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA and Pr3-ANCA) in the pathogenesis of glomerular/vascular injury. In the past years, I generated a MPO-ANCA disease mouse model that facilitated the studies of the mechanisms of the ANCA disease. By using this mouse model, I have studied the role of inflammatory cells, cytokines and complements in the pathogenesis of ANCA disease. Recently I have been working on developing a Pr3-ANCA mouse disease model as well. My goal aims to find out potential targets for therapeutic intervention of ANCA glomerulonephritis and vasculitis.
Xiao H, Hu P, Falk RJ, Jennette JC. Overview of the Pathogenesis of ANCA-Associated Vasculitis. Kidney Diseases 2015;1:205–215.
Xiao H, Dairaghi DJ, Powers JP, Ertl LS, Baumgart T, Wang Y, Seitz LC, Penfold MET, Gao L, Hu1 P, Lu B, Gerard NP, Gerard C, Schall TJ, Jaen JC, Falk RJ, Jennette JC. C5a Receptor (CD88) Blockade Protects against MPO-ANCA Glomerulonephritis. J Am Soc Nephrol 2014; 25:225-231.
Xiao H, Ciavatta DJ, Aylor LD., Hu P, de Villena FPM, Falk RJ, and Jennette JC: Genetically Determined Severity of Anti-Myeloperoxidase Glomerulonephritis. Am J Pathol April 2013; vol 182 (4):1219-1226.
Xiao H: The role of genetic background in an animal model of ANCA-associated vasculitis. La Presse Médicale April 2013;Vol 42 (4), Part 2, 517–517–520.
Schreiber A, Xiao H, Jennette JC, Schneider W, Luft FC, Kettritz R: C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis. J Am Soc Nephrol. 2009 Feb; 20(2):289-98.
Huugen D, van Esch A, Xiao H, Peutz-kootstra CJ, Buuman WA, Tervaert JW, Jennette JC, Herringa P.Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int. 2007 Apr; 71(7):646-54.
Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies. Am J Pathol January 2007, Vol. 170 (1): 52-64.
Schreiber A, Xiao H, Falk RJ, Jennette JC. Bone Marrow-Derived Cells Are Sufficient and Necessary Targets to Mediate Glomerulonephritis and Vasculitis Induced by Anti-Myeloperoxidase Antibodies. J Am Soc Nephrol 2006 Dec; 17 (12): 3355-64.
Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 2006 May, 17(5):1235-42.
Xiao H, Heeringa P, Liu Z, Huugen D, Hu P, Falk RJ, Jennette JC: A major role for neutrophils in anti-myeloperoxidase antibody induced necrotizing and crescentic glomerulonephritis. Am J Pathol 167:39-45, 2005.
Huugen D, Xiao H, Jennette JC, Heeringa P: Aggravation of anti-myeloperoxidase antibody induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor a. Am J Pathol 167:47-58, 2005.
Xiao H, Heringa Peter, Hu P, Liu Z, Zhao M, Aratani Y, Maeda NN, Falk RJ, Jennette JC. Antineutrophil Cytoplasmic Autoantibodies Specific for Myeloperoxidase Cause Glomerulonephritis and Vesculitis in Mice. J Clin Invest 2002; 110:955-963.