The University of North Carolina at Chapel Hill
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UNC School of Medicine

Steven T. Shipley, DVM, DACLAM

Research Professor Associate Director of Veterinary Services, Division of Comparative Medicine

Research Interests

My research has focused in three primary areas—composite tissue transplantation, infectious disease research, and control algorithms for automated critical care systems. 

As a member of the Division of Comparative Medicine and a Laboratory Animal Veterinarian, I am very interested in health problems that affect both humans and animals. An excellent area to combine these interests is in the area of infectious disease, since many diseases affect both people and animals. In addition to this work a longstanding collaboration in the transplantation of composite tissue and the modulation of the immune response to this tissue has been both challenging and exciting. My recent collaboration with engineering colleagues to help develop automated critical care systems using swine models has also been very stimulating. I look forward to continuing these areas of study and taking advantage of whatever additional research opportunities present themselves in the future.

Publications

  1. Limei Shen, Zhongbo Li, Alice Ma, Carlos Cruz-Teran, Anne Talkington, Steven T. Shipley, and Samuel K. Lai.  Free PEG Suppresses Anaphylaxis to PEGylated Nanomedicine in Swine. ACS Nano Article ASAP. https://pubs.acs.org/doi/10.1021/acsnano.3c11165
  2. Haney, M. J., Yuan, H., Shipley, S. T., Wu, Z., Zhao, Y., Pate, K., Frank, J. E., Massoud, N., Stewart, P. W., Perlmutter, J. S., Batrakova, E. V., Biodistribution of Biomimetic Drug Carriers, Mononuclear Cells, and Extracellular Vesicles, in Nonhuman Primates. Adv. Biology 2021, 2101293. https://doi.org/10.1002/adbi.202101293
  3. Galex, l.A., Shipley, S. Residents and regulations—always an adventure. Lab Anim 49, 235 (2020). https://doi.org/10.1038/s41684-020-0619-9
  4. J. Zhu, X. Jin, R. Bighamian, C.S. Kim, S.T. Shipley, J.O. Hahn. Semi-Adaptive Infusion Control of Medications with Excitatory Dose-Dependent Effects. IEEE Transactions on Control Systems Technology.  Vol 27, Issue 4.  P 1735-1743.  July 2019. DOI: 10.1109/TCST.2018.2815551
  5. Jin X, Kim C, Shipley S, Dumont GA, Hahn J. Semi-Adaptive Closed-Loop Control for Infusion of Medications with Transport Delay in Clinical Effects. ASME. J. Comput. Nonlinear Dynam. 2019;():. doi:10.1115/1.4042686.
  6. E.E. Higginson, G. Ramachandran, A. Panda, S. Shipley, E.H. Kriel, L.J. DeTolla, M. Lipsky, D.J. Perkins, R. Salerno-Goncalves, M.B. Sztein, M.F. Pasetti, M.M. Levine, S.M. Tennant.  Improved tolerability of a Salmonella Typhimurium live-attenuated vaccine strain by balancing inflammatory potential with immunogenicity.  Infection and Immunity.  2018 Nov 20;86(12).
  7. Shipley ST, Estes J.  Response to Protocol Review Scenario:  Reporting is unnecessary, but preventing further unexpected deaths is key.  Lab Anim (NY). 2018 Jan 31;47(2):30-31. doi: 10.1038/laban.1402
  8. Xin Jin, Chang-Sei Kim, Steven Shipley, Guy Dumont, Jin-Oh Hahn.  Coordinated Semi-Adaptive Closed-Loop Control for Infusion of Two Interacting Medications.  International Journal of Adaptive Control and Signal Processing. Vol. 21, No. 1, pp. 134-146, January 2018.
  9. Xin Jin, Chang-Sei Kim, Steven Shipley, Guy Dumont, Jin-Oh Hahn.  Coordinated and Semi-Adaptive Cardiorespiratory Control Via Sedative and Opioid Drugs.  Oral presentation and published paper in proceedings.  2017 ASME Dynamic Systems and Control Conference, October 11-13, 2017.  Tysons Corner, VA.

List of publications from PubMed

Image of Steve Shipley