Rad18 E3 ubiquitin ligase is the main enzyme for Trans-Lesion Synthesis (TLS) pathway, and is known to respond to several forms of DNA damage including replication stalling, DNA single stranded breaks, DNA double stranded breaks. However, the precise mechanisms by which Rad18 promotes tolerance of genotoxic/oncogenic stress and chemotherapeutic drug are still ambiguous. My research goal is to identify the mechanisms by which Rad18 is promoting tolerance of DNA damage and replication stress in vitro and in vivo.
Yang Yang, Yanzhe Gao, Anastasia Zlatanou, Satoshi Tateishi, Vyacheslav Yurchenko, Igor B. Rogozin and Cyrus Vaziri. Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis. Cell Cycle, 2018 May 8:1-11.
Yang Yang, Yanzhe Gao, Liz Mutter-Rottmayer, Anastasia Zlatanou, Michael Durando, Weimin Ding, David Wyatt, Dale Ramsden, Yuki Tanoue, Satoshi Tateishi and Cyrus Vaziri. RAD18 and DNA Polymerase kappa (Polκ) Are Necessary for Tolerance of Oncogene-Induced DNA Replication Stress. Journal of Cell Biology, 2017 Oct 2;216(10):3097-3115.
Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel Martinez-Chacin, Kenneth Pearce, Satoshi Tateishi, Ben Major, and Cyrus Vaziri. A Neomorphic Cancer Cell-Specific Role of MAGE-A4 in Trans-Lesion Synthesis, Nature Communications. 2016 Jul 5;7:12105. [PMID: 27377895]
Yang Yang, Jonathan C. Poe, Lisong Yang, Andrew Fedoriw, Siddhi Desai, Terry Magnuson, Zhiguo Li, George Fedoriw, Kimi Araki, Satoshi Tateishi, Stefanie Sarantopoulos and Cyrus Vaziri. Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in mice, Nucleic Acids Research, 2016 May 19;44(9):4174-88. [PMID:26883629]
Yang Yang, Micheal Durando, Stephanie L. Smith-Roe, Chris Sproul, Alicia M. Greenwalt, William Kaufmann, Sehyun Oh, Eric A. Hendrickson and Cyrus Vaziri. Cell Cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage, Nucleic Acids Research, 2013 Feb 1; 41(4):2296-312 [PMID:23295675]
Ti-Cheng Chang, Yang Yang, Ernest F. Retzel, Wan-Sheng Liu. The male-specific region of the bovine Y chromosome is gene-rich with a high transcriptomic activity in testis development, Proc. Natl. Acad. Sci. USA 2013 Jul 23;110(30):12373-8. [PMID:23842086]
Yang Yang, Ti-Cheng Chang, Hiroshi Yasue, Arvind K Bharti, Ernest F Retze, Wan-Sheng Liu. ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in Bovidae, BMC Genomics 2011, 12:13 [PMID:21214936]
Chang T-C, Yang Y, Yasue H, Bharti AK, Retzel EF, et al. The Expansion of the PRAME Gene Family in Eutheria. PLoS ONE 2011 6(2): e16867. [PMID:21347312]
Liu, W.-S., Wang, A.-H., Yang, Y., Chang, T.-C., Landrito, E., Yasue, H. Molecular characterization of the DDX3Y gene and its homologs in cattle. Cytogenetic and Genome Research 2009;126(4):318-28. [PMID:20016128]
Kei Miyamoto , Tomoyuki Tsukiyama , Yang Yang , Ning Li , Naojiro Minami , Masayasu Yamada , and Hiroshi Imai. Cell-Free Extracts from Mammalian Oocytes Partially Induce Nuclear Reprogramming in Somatic Cells, Biol Reprod 2009 May;80(5):935-43. [PMID:19164171]
Y.Yang, W. Liu, Z.L. Liu, X.X. Hu, N. Li. 2004, Mapping NANOG to Chromosome 5 in Swine, ANIMAL GENETICS 35 (5): 411 [PMID:15373748]