Nathan D. Montgomery, MD, PhD

Assistant Professor

Director of Molecular Hematopathology
Associate Director of Hematopathology and Molecular Pathology

Office: 822 Brinkhous-Bullitt Bldg.
Phone: 919-445-6414
Email:

Research Interests

  • Genomic features of hematologic malignancies
  • Diagnostic capacity building in resource-limited settings

Overview of Research and Clinical Work

Dr. Montgomery’s primary clinical and research interests center on the underlying biology and genetic features of hematolymphoid neoplasms. Much of his work centers on application of molecular and cytogenetic tools to clinical diagnostics. This work has included both retrospective studies to better understand test performance characteristics of existing molecular and cytogenetic assays, as well as new assay development focused on mutation and virus detection in tumor specimens. A separate research focus is based on diagnostic capacity building in sub-Saharan Africa, with an emphasis on HIV-associated lymphoma and other virally-driven lymphoproliferative disorders.

Selected Publications

Johnson SM, Umakanthan JM, Yuan J, Fedoriw Y, Bociek RG, Kaiser-Rogers K, Sanmann JN, Montgomery ND. “Lymphomas with pseudo-double-hit BCL6-MYC translocations due to t(3;8)(q27;q24) are associated with a germinal center immunophenotype, extranodal involvement, and frequent BCL2 translocations.” Hum Pathol. 2018. 80:192-200. PMID: 29902576

Anders PM, Montgomery ND, Montgomery SA, Bhatt AP, Dither DP, Damania B. “Human herpesvirus-encoded kinase induces B cell lymphomas in vivo.” J Clin Invest. 2018. 128(6):2519-2534. PMID: 29733294

Montgomery ND, Tomoka T, Krysias R, Powers E, Mulenga M, Kampani C, Chimzimu F, Owino MK, Dhungel BM, Gopal S, Fedoriw Y. “Practical Successes in Telepathology Experiences in Africa.” Clin Lab Med. 2018. 38(1):141-150. PMID: 29412878

Montgomery ND, Selitsky SR, Patel NM, Hayes DN, Parker JS, Weck KE. “Identification of Germline Variants in Tumor Genomic Sequencing Analysis.” J Mol Diagn. 2018. 20(1):123-125. PMID: 29249243

Montgomery ND, Coward WB 4th, Johnson S, Yuan J, Gulley ML, Mathews SP, Kaiser-Rogers K, Rao KW, Sanger WG, Sanmann JN, Fedoriw Y. “Karyotypic abnormalities associated with Epstein-Barr virus status in classical Hodgkin lymphoma.” Cancer Genet. 2016. 209(9):408-416. PMID: 27751359

Montgomery ND, Liomba NG, Kampani C, Krysiak R, Stanley CC, Tomoka T, Kamiza S, Dhungel BM, Gopal S, Fedoriw Y. “Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences: A Model of Pathology Services in Sub-Saharan Africa.” Am J Clin Pathol. 2016. 146(4):423-30. PMID: 27594430

Montgomery ND, Mathews SP. “Transformation in Low-grade B-cell Neoplasms.” Surg Pathol Clin. 2016. 9(1):79-92. PMID: 26940269

Treece AL, Montgomery ND, Patel NM, Cavalier CJ, Dodd LG, Gulley ML, Booker JK, Weck KE. “FNA smears as a potential source of DNA for targeted next-generation sequencing of lung adenocarcinomas.” Cancer Cytopathol. 2016. 124(6):406-414. PMID: 26882436

Gopal S, Fedoriw Y, Montgomery ND, Kampani C, Krysiak R, Sanders MK, Dittmer DP, Liomba NG. “Multicentric Castleman’s disease in Malawi.” Lancet 2014. 384(9948):1158. PMID: 25241721

Montgomery ND, Fedoriw Y. “Pathology consultations on intermediate-to-large B-cell lymphomas.” Am J Clin Pathol. 2014. 141(3):305-317. PMID: 24515757

Montgomery ND, Mathews SP, Coward WB 4th, Rao KW, Fedoriw Y. “Clonal karyotypic abnormalities associated with reactive lymphoid hyperplasia.” Cancer Genet. 2013. 206(4):135-9. PMID: 23623181

Montgomery ND, Dunphy CH, Mooberry M, Laramore A, Foster MC, Park SI, Fedoriw YD. “Diagnostic complexities of eosinophilia.” Arch Pathol Lab Med. 2013. 137(2):259-69. PMID: 23368869

List of publications from PubMed