Dr. Iuga

Alina Iuga, MD

Associate Professor

Director of Gastrointestinal Pathology

Office: 984-974-9148
Email: Alina.Iuga@unchealth.unc.edu

Research Interests

Histopathology as a tool to support innovation and discovery through clinical and translational research on inflammatory and neoplastic disorders of the digestive system.

Selected Publications

Cysteine depletion induces pancreatic tumor ferroptosis in mice. Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP. Science. 2020 Apr 3;368(6486):85-89.

Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques – an experimental study. Berglund E, Alonso-Guallart P, Danton M, Sellberg F, Binder C, Fröbom R, Berglund D, Llore N, Sakai H, Iuga A, Ekanayake-Alper D, Reimann KA, Sachs DH, Sykes M, Griesemer A. Transpl Int. 2020 Jan;33(1):98-107.

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC. Cancer Cell. 2018 Jan 8;33(1):75-90.e7.

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness. Renz BW, Tanaka T, Sunagawa M, Takahashi R, Jiang Z, Macchini M, Dantes Z, Valenti G, White RA, Middelhoff MA, Ilmer M, Oberstein PE, Angele MK, Deng H, Hayakawa Y, Westphalen CB, Werner J, Remotti H, Reichert M, Tailor YH, Nagar K, Friedman RA, Iuga AC, Olive KP, Wang TC. Cancer Discov. 2018 Nov;8(11):1458-1473

Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma. Dunkin D, Iuga AC, Mimouna S, Harris CL, Haure-Mirande JV, Bozec D, Yeretssian G, Dahan S. Oncotarget. 2018 Sep 11;9(71):33536-33548.

Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23. Chen L, He Z, Iuga AC, Martins Filho SN, Faith JJ, Clemente JC, Deshpande M, Jayaprakash A, Colombel JF, Lafaille JJ, Sachidanandam R, Furtado GC, Lira SA. Gastroenterology. 2018 Oct;155(4):1177-1191.e16.

A functional genomics predictive network model identifies regulators of inflammatory bowel disease. Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE. Nat Genet. 2017 Oct;49(10):1437-1449.

Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis. Bozec D, Iuga AC, Roda G, Dahan S, Yeretssian G. Oncotarget. 2016 Jul 19;7(29):46384-46400.

Mouse and human Notch-1 regulate mucosal immune responses. Mathern DR, Laitman LE, Hovhannisyan Z, Dunkin D, Farsio S, Malik TJ, Roda G, Chitre A, Iuga AC, Yeretssian G, Berin MC, Dahan S. Mucosal Immunol. 2014 Jul;7(4):995-1005.

Anti-inflammatory Effects of the Chinese Herbal Formula FAHF-2 in Experimental and Human IBD. Song Y, Dunkin D, Dahan S, Iuga A, Ceballos C, Hoffstadter-Thal K, Yang N, Benkov K, Mayer L, Li XM. Inflamm Bowel Dis. 2014 Jan;20(1):144-53.

A role for EGFR signaling in the development of intestinal serrated polyps in mice and humans. Bongers G, Muniz LR, Pacer M, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Premkumar Reddy E, Mayer L, Furtado GC, Harpaz N, Lira SA Gastroenterology 2012 Sep;143(3):730-40.

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. Nature, 2006 Jun; 441(7093):646-50.

List of publications from PubMed