Ruth Winecker

Ruth E. Winecker, PhD, D-ABFT

Associate Professor

Chief Toxicologist,
N. C. Office of the Chief Medical Examiner

Office: 919-743-9000


Research Interests

Forensic toxicology including post-mortem redistribution of drugs, analytical methodology, reviews of therapeutic and abused drugs, the toxicology of metals, and the measurement of therapeutic and abused drugs in alternative matrices such as hair, amniotic fluid, umbilical cord tissue, meconium and breast milk.

Selected Publications

Books and Book Chapters:

Winecker RE: Quantification of Antidepressants using Gas Chromatography Mass Spectrometry. In: Clinical Applications of Mass Spectrometry, Hammet-Stabler CH and Garg U, eds. Humana Press, Clifton, NJ. 2010. (pp. 45-56).

Bertholf RL and Winecker RE, eds: Chromatographic Methods in Clinical Chemistry and Toxicology. John Wiley & Sons, Inc., London, England. 2007.

Journal Articles (refereed):

Bishop-Freeman, Sandra C.; Brower, Justin O, Feaster, Marc S, Miller, Allison; Hargrove, Robert L, Winecker, Ruth E. Loperamide-Related Deaths in North Carolina. J Anal Toxicol. 2016 Oct; 40(8):677-686.

Bishop-Freeman, Sandra C.; Miller, Allison; Hensel, Erin; Winecker, Ruth E. Postmortem Metaxalone (Skelaxin®) Data from North Carolina. J Anal Toxicol. 2015 Oct; 39(8):629-36. doi: 10.1093/jat/bkv066).

Bishop-Freeman, Sandra C.; Kornegay, Nina C.; Winecker, Ruth E. Postmortem Levetiracetam (Keppra®) Data from North Carolina. J Anal. Toxicol. July 36:422–428 (2012).

Howard, Matthew O. PhD; Hall, Martin T. PhD; Edwards, Jeffrey D. MSW; Vaughn, Michael G. PhD; Perron, Brian E. PhD; Winecker, Ruth E. PhD. Suicide By Asphyxiation Due to Helium Inhalation. American Journal of Forensic Medicine & Pathology. March 32(1):61-70 (2011).

D Garside, RL Hargrove, RE Winecker. Concentration of Oxymorphone in Postmortem Fluids and Tissue. J Anal. Toxicol. April, 33:121-128 (2009).

S Thomas, RE Winecker and JP Pestaner. Unusual Fentanyl Patch Administration. The American Journal of Forensic Medicine and Pathology. June, 29:162-163 (2008).

ND Bynum, JL Poklis, D Garside and RE Winecker. Postmortem Memantine Concentrations. . J Anal Toxicol. May; 31:233-236 (2007).

JD Ropero-Miller and RE Winecker. Case Report: Overdose from Deliberate Duragesic Misuse. AACC Clinical and Forensic Toxicology News. Sept: 1, 2-3 (2006).

Winecker RE. Immunoassays Continue to Improve, Expand and Evolve. AACC Clinical and Forensic Toxicology News. March: 1, 7-10 (2005).

JL Poklis, JD Ropero-Miller, D Garside and RE Winecker: Case Report: Metaxalone (Skelaxin ®) Related Death. J Anal Toxicol. Oct; 28:537-541 (2004).

Tharp AM, Winecker RE and Winston DC. Fatal intravenous fentanyl abuse: four cases involving extraction of fentanyl from transdermal patches. Am J Forensic Med Pathol. Jun;25(2):178-81 (2004).

Winecker RE. Methadone: An Old Drug Achieves New Notoriety. AACC Clinical and Forensic Toxicology News. June: 1-5 (2003).

Winecker RE, Ropero-Miller J, Broussard LA, Hammett-Stabler CA. The Toxicology of Heavy Metals. Part III. Getting the Lead Out. Laboratory Medicine 33: 934-947 (2002).

Winecker RE, Hammett-Stabler CA, Chapman JF, Ropero-Miller JD: HbA1c as a Postmortem Tool to Identify Glycemic Control. J Forensic Sci; 47(6): 1373-1379 (2002).

Ropero-Miller JD, Lambing MK, Winecker RE. Simultaneous quantification of opioids in blood by EI-GC-MS analysis following deproteination, detautomerization of keto analytes, solid phase extraction, and trimethylsilyl derivatization. J Anal Toxicol 2002 26:524-528.

Broussard LA, Hammett-Stabler CA, Winecker RE, Ropero-Miller J. The Toxicology of Heavy Metals. Part II. Mercury. Laboratory Medicine 33: 614-625 (2002).

Hammett-Stabler CA, Broussard LA, Winecker RE, Ropero-Miller JD: The toxicology of Heavy Metals. Part 1: New Insights into an Old Poison, Arsenic. Laboratory Medicine; 33:437-447 (2002).

Winecker RE, Goldberger BA, Tebbett IR, Behnke M, Eyler FD, Karlix J, Wobie K, Phillips D and Bertholf RL: Measurement of cocaine and metabolites in breast milk. J Forensic Sci 46(5): 213-215 (2001).

Ropero-Miller JD, Paget-Wilkes H, and Winecker RE. Pharmacological Treatment of Sexual Dysfunction: From Yohimbe to Viagra. Therapeutic Drug Monitoring and Toxicology. 3:71-81 (1999).

Winecker RE, Goldberger BA, Tebbett IR, Behnke M, Eyler F D, Conlan M, Wobie K, Karlix J, and Bertholf RL. Detection of Cocaine and its Metabolites in Amniotic Fluid and Umbilical Cord Tissue. J. Anal. Toxicol. 21:97-104 (1997).

View list of publications from PubMed