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Course Offerings<\/h2>\n
This page provides a brief description of courses offered by the Pathobiology and Translational Science graduate program, and the faculty of the Department of Pathology and Laboratory Medicine. Courses that are infrequently offered are not listed.<\/p>\n
Courses for Graduate Students<\/h3>\nPATH 713 Mechanisms of Disease (3 Hours)<\/h3>\n
A graduate course on cell injury and pathogenesis of disease with emphasis on basic mechanisms at the molecular, cellular, and organismal levels. Prerequisite: None. Three hours lecture and 2.5 hours laboratory each week. Offered Fall semester. Course Directors: J.W. Homeister jonathon_homeister@med.unc.edu<\/span><\/a><\/p>\n A graduate laboratory course on cell injury and pathogenesis of disease featuring microscopic and gross pathology specimens. Prerequisite: Pathology 713. Can be taken concurrently with Pathology 713. Three hours laboratory each week. Offered Fall semester. Course Director: V.L. Godfrey virginia_godfrey@med.unc.edu<\/span><\/a><\/p>\n Thisis a 2-hour course for biomedical science graduate students that are interested in translation of basic science into clinical practice, irrespective of primary discipline. This course will address (i) core competencies for translational researchers, (ii) fundamental molecular approaches that form the basis for translational science, (iii) fundamentals of personalized medicine, (iv) concepts related to team science, (v) commercialization of basic science, and (vi) industrial translational science. Offered Spring semester. Course Directors: E. Weimer eric.weimer@unchealth.unc.edu<\/a> and K. Alby kevin_alby@unc.edu<\/span><\/a><\/span><\/p>\n This course will cover a range of topics including cancer etiology, mechanism, pathogenesis, hallmark and clinical features, and treatment. Lecturers will emphasize an interdisciplinary approach drawing on observations from epidemiology, genetics, molecular biology, animal modeling, histopathology and clinical medicine. The intent is to provide a firm foundation in pathobiologic features of cancer and thereby facilitate the translation of bench science into the clinical laboratory. Three lecture hours per week. Offered Fall semester. Course Director: A. Gladden agladden@email.unc.edu<\/span><\/a><\/p>\n This course emphasizes recent advances in heart and blood vessel development and the molecular mechanisms that regulate cardiovascular cell function. It is taught by UNC faculty of the McAllister Heart Institute and will stress primary literature and current methodologies. In general, course-work will consist of discussion and presentation of assigned manuscripts. Offered Fall semester. Course Director: Christopher Mack cmack@med.unc.edu<\/span><\/a><\/p>\n This advanced course will explore the underlying pathogenesis of clinical cardiac and vascular disease with the objective of teaching students to understand, investigate, and communicate current concepts of cardiovascular disease. Study topics include hypertensions, lipid metabolism and atherosclerosis, metabolic syndrome, myocardial injury, heart failure, angiogenesis, thrombosis and thrombolysis, genetics and epidemiology of cardiovascular disease, and others. Offered Spring semester. Course Directors: J.W. Homeister jonathon_homeister@med.unc.edu<\/a><\/p>\n This course is designed for second to third-year students who intend on performing in vivo animal research. This course is intended to familiarize graduate students in the issues associated with the development and interpretation of mouse models and also an introduction to alternative models. Offered Spring semester. Course Director R. Sellers rsselle@unc.edu<\/a><\/p>\n This journal club-style discussion course explores the molecular mechanisms regulating normal cell cycle progression and how their deregulation leads to cancer. We will trace the historical development of the cell cycle field, illustrating how scientific inquiry has shaped current paradigms. This course is ideal for students interested in cell proliferation and cancer biology, regardless of prior knowledge. Beyond providing a thorough understanding of the cell cycle, a major goal of this course is to develop students\u2019 grant-writing skills, specifically in preparing F31 fellowship applications. The first part of the course emphasizes the scientific method \u2013 teaching students how to identify key problems, formulate testable hypotheses, analyze experimental data, and build new biological models. The course then transitions into a grant-writing boot camp, where students learn to craft persuasive fellowship proposals. Offered Fall semester. Course Director: C. Vaziri cyrus_vaziri@med.unc.edu<\/a> and J. Bowser jlbowser@email.unc.edu\u00a0<\/a><\/span><\/p>\n<\/div>\n This course is designed for second to third-year students who have chosen their thesis lab.\u00a0\u00a0The students will develop a research plan based on their thesis project and write an 8-page grant in the style of an NRSA F31 application.\u00a0\u00a0Students will learn to edit and critique their fellow students\u2019 proposals which will help prepare the students for writing and editing their preliminary exam and future grant applications. Offered Spring semester. Course Director: A. Gladden agladden@email.unc.edu<\/a><\/p>\n This is a research course in which advanced students in pathology carry on investigations on mechanisms of disease. Six or more laboratory hours per week. May be repeated. Offered Fall and Spring semesters, and Summer sessions. Instructors: Staff.<\/p>\n May be repeated. Offered Fall and Spring semesters, and Summer sessions. Instructors: Staff.<\/p>\n<\/div>\n<\/div>\nPATH 714 Mechanisms of Disease Laboratory (2 Hours)<\/h3>\n
PATH 723 Practical Considerations for Translational Research (2 Hours)<\/h3>\n
PATH 725 Cancer Pathology (3 Hours)<\/h3>\n
PATH 766 Current Topics in Cardiovascular Biology (3 Hours)<\/h3>\n
PATH 767 Molecular and Cellular Biology of Cardiovascular Disease (3 Hours)<\/h3>\n
PATH 770 The Mouse Efficacy and Disease Models (3 Hours)<\/h3>\n
PATH 801 Critical Thinking in Science: From Hypothesis to Grant Proposal<\/span> (3 Hours)<\/h3>\n
PATH 850 Pathology Scientific Writing (1 Hour)<\/h3>\n
PATH 900 Research in Pathology (2-12 Hours)<\/h3>\n
PATH 994 Doctoral Dissertation (Hours\/credits vary)<\/h3>\n