{"id":2184,"date":"2017-09-15T15:46:49","date_gmt":"2017-09-15T15:46:49","guid":{"rendered":"https:\/\/wordpress-dev.med.unc.edu\/millerlab\/?page_id=7"},"modified":"2018-12-27T11:41:43","modified_gmt":"2018-12-27T16:41:43","slug":"home-2","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/","title":{"rendered":"Home"},"content":{"rendered":"
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C. Ryan Miller Lab @ UNC<\/h2>\n
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Translational Neuro-oncology Laboratory<\/p>\n

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Mission<\/h3>\n

To develop\u00a0genomics<\/a>-driven approaches to diagnosis and treatment of\u00a0gliomas<\/a>, the most common primary brain tumors.<\/p>\n

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Research Overview<\/h3>\n

Precision medicine<\/a>\u00a0promises to revolutionize oncology by tailoring treatments to specific mutations that drive cancer. \u00a0However, this approach fails to account for the dynamic state of tumor cells and their ability to adapt to an ever-changing tumor microenvironment. \u00a0Our laboratory focuses on defining the molecular changes that drive the evolution of gliomas during their progression from low-grade precursors to \u00a0malignant,\u00a0high-grade\u00a0neoplasms. \u00a0We are particularly focused on the most aggressive glioma,\u00a0glioblastoma<\/a>, and seek to:<\/p>\n

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  1. Identify the cell type(s) from which these lethal tumors arise;<\/li>\n
  2. Define the role of tumor cell plasticity and glioma stem cells (GSC) in glioma biology;<\/li>\n
  3. Define the wiring diagrams that control proliferation and migration\/invasion of glioma cells that arise from different cell types in the normal mammalian brain.<\/li>\n<\/ol>\n

    Our laboratory uses sophisticated preclinical model systems and cutting-edge genomic and proteomic techniques to address these questions.<\/p>\n

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