{"id":49,"date":"2017-09-15T16:49:43","date_gmt":"2017-09-15T16:49:43","guid":{"rendered":"https:\/\/wordpress-dev.med.unc.edu\/millerlab\/?page_id=49"},"modified":"2018-09-07T17:19:42","modified_gmt":"2018-09-07T21:19:42","slug":"ryan-e-bash-ms","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/lab-members\/ryan-e-bash-ms\/","title":{"rendered":"Ryan E. Bash, MS"},"content":{"rendered":"
\n
\n
\n
\n

<\/h3>\n

\"\"<\/h3>\n

Research Specialist<\/p>\n

Department of Pathology and Laboratory Medicine<\/a>
\n6105 Neurosciences Building<\/p>\n

919-966-0587<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

ryan_bash [at] med.unc.edu<\/a><\/p>\n

 <\/p>\n

 <\/p>\n

\n
\n

Education<\/h2>\n<\/div>\n

University of North Carolina School of Medicine<\/h3>\n

Masters of Science (MS), June 2010<\/p>\n

\u00a0Curriculum in Genetics and Molecular Biology<\/a><\/p>\n

University of North Carolina<\/h3>\n

Bachelor of Science,\u00a0December 2000<\/p>\n

Major:\u00a0\u00a0Biology<\/a><\/p>\n

\n
\n

Publications<\/h2>\n<\/div>\n
    \n
  1. McNeill RS,\u00a0Stroobant EE,\u00a0Smithberger E,\u00a0Canoutas DA,\u00a0Butler MK,\u00a0Shelton AK,\u00a0Patel SD, Limas JC,\u00a0Skinner KR,\u00a0Bash RE<\/strong>,\u00a0Schmid RS,\u00a0<\/strong>Miller CR.\u00a0 PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.\u00a0 PLoS One.\u00a0 13(7):e0200014 Jul 2018.\u00a0 PMID:\u00a029975751<\/a>\u00a0 PMCID:\u00a0PMC6033446<\/a><\/li>\n
  2. Wu J, Frady LN, Bash RE<\/strong>, Cohen SM, Schorzman AN, Su YT, Irvin DM, Zamboni WC, Wang X, Frye SV, Ewend MG, Sulman EP, Gilbert MR, Earp HS, Miller CR.\u00a0 MerTK as a therapeutic target in glioblastoma.\u00a0 Neuro-oncology. 20(1):92-102 Jan 2018.\u00a0 PMID: 28605477<\/a> \u00a0PMCID:\u00a0 PMC5761530<\/a><\/li>\n
  3. Van Swearingen AED, Sambade MJ, Siegel MB, Sud S, McNeill RS, Bevill SM, Chen X, Bash RE<\/strong>, Mounsey L, Golitz BT, Santos C, Deal A, Parker JS, Rashid N, Miller CR, Johnson GL, Anders CK.\u00a0 Combined kinase inhibitors of MEK1\/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.\u00a0 Neuro-oncology.\u00a0 19(11):1481-1493 Oct 2017.\u00a0 PMID: 28486691<\/a> \u00a0PMCID:\u00a0 PMC5737524<\/a><\/li>\n
  4. McNeill RS, Canoutas DA, Stuhlmiller TJ, Dhruv HD, Irvin DM, Bash RE<\/strong>, Angus SP, Herring LE, Simon JM, Skinner KR, Limas JC, Chen X, Schmid RS, Siegel MB, Van Swearingen AED, Hadler MJ, Sulman EP, Sarkaria JN, Anders CK, Graves LM, Berens ME, Johnson GL, Miller CR.\u00a0 Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.\u00a0 Neuro-oncology.\u00a0 19(11):1469-1480 Oct 2017.\u00a0 PMID: 28379424<\/a> \u00a0PMCID:\u00a0 PMC5737415<\/a><\/li>\n
  5. Vitucci M*, Irvin DM*, McNeill RS, Schmid RS, Simon JM, Dhruv HD, Siegel MB, Werneke AM, Bash RE<\/strong>, Kim S, Berens ME, Miller CR.\u00a0 Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.\u00a0 Neuro-oncology.\u00a0 19(9):1237-1247 Sep 2017.\u00a0 *Co-first authors.\u00a0 PMID: 28398584<\/a> \u00a0PMCID:\u00a0 PMC5570221<\/a><\/li>\n
  6. Schmid RS, Simon JM,\u00a0Vitucci M,\u00a0McNeill RS,\u00a0Bash RE<\/strong>,\u00a0Werneke AM,\u00a0Huey L,\u00a0White KK, Ewend MG,\u00a0Wu J,\u00a0Miller CR.\u00a0 Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation, but resistant to temozolomide.\u00a0 Neuro-oncology.\u00a0 18(7):962-973 Jul 2016.\u00a0 PMID:\u00a026826202<\/a>\u00a0 PMCID:\u00a0PMC4896545<\/a><\/li>\n
  7. Okolie O, Bago JR,\u00a0Schmid RS,\u00a0Irvin DM,\u00a0Bash RE<\/strong>,\u00a0Miller CR*, Hingtgen SD*.\u00a0 Reactive astrocytes potentiate tumor aggressiveness in murine glioma resection and recurrence model.\u00a0 Neuro-oncology.\u00a0 DOI: 10.1093\/neuonc\/now117 Jun 2016.\u00a0 PMID:\u00a027298311<\/a>\u00a0 *Co-senior authors.<\/li>\n
  8. Irvin DM,\u00a0McNeill RS,\u00a0Bash RE<\/strong>,\u00a0Miller CR.\u00a0 Intrinsic astrocyte heterogeneity influences tumor growth in glioma mouse models.\u00a0 Brain Pathology.\u00a0 Epub Jan 13, 2016.\u00a0 DOI: 10.1111\/bpa.12348.\u00a0 PMID:\u00a026762242<\/a><\/li>\n
  9. Karginova O, Siegel MB, Adamo B, Deal AM, Van Swearingen AED, Nikolaishvili-Feinberg N, Parker JS, Santos CM, Darr D, Bash R<\/strong>, Sandison K, Zamboni WC,\u00a0Miller CR, Anders CK.\u00a0 Efficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple negative breast cancer.\u00a0 Molecular Cancer Therapeutics.\u00a0 14(4):920-930 Apr 2015. PMID:\u00a025824335<\/a>\u00a0 PMCID:\u00a0PMC4394032<\/a><\/li>\n
  10. McNeill RS,\u00a0Schmid RS,\u00a0Bash RE<\/strong>,\u00a0Vitucci M,\u00a0White KK,\u00a0Werneke AM,\u00a0Constance BH,\u00a0Huff B,\u00a0Miller CR.\u00a0 Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.\u00a0 Journal of Visualized Experiments.\u00a0 90:e51763 Aug 2014.\u00a0 PMID:\u00a025146643<\/a>.<\/li>\n
  11. Song Y, Zhang Q, Kutlu B, Difilippantonio S,\u00a0Bash R<\/strong>, Gilbert D, Yin C, O\u2019Sullivan TN, Yang C, Kozlov S, Bullitt E, McCarthy KD, Kafri T, Louis DN,\u00a0Miller CR, Hood L, Van Dyke T.\u00a0 Evolutionary etiology of high-grade astrocytomas.\u00a0 Proceedings of the National Academy of Science USA.\u00a0 110(44):17933-17938 Oct 2013. \u00a0PMID:\u00a024114272<\/a>\u00a0PMCID:\u00a0PMC3816471<\/a><\/li>\n
  12. Vitucci M, Karpinich NO,\u00a0Bash RE<\/strong>,\u00a0Werneke AM,\u00a0Schmid RS,\u00a0White KK,\u00a0McNeill RS,\u00a0Huff B, Wang S, Van Dyke T,\u00a0Miller CR.\u00a0 Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis. \u00a0Neuro-oncology.\u00a0 15(10):1317-1329 Oct 2013.\u00a0 PMID:\u00a023814263<\/a>\u00a0 PMCID:\u00a0PMC3779038<\/a><\/li>\n
  13. Anders CK, Adamo B, Karginova O, Deal AM, Rawal S, Walsh M, Darr D, Schorzman A, Santos C, Bash R<\/strong>, Kafri T, Carey L,\u00a0Miller CR, Perou CM, Sharpless N, Zamboni WC.\u00a0 Pharmacokinetics and efficacy of PEGylated liposomal doxorubicin in an intracranial model of breast cancer.\u00a0 PLoS One.\u00a0 8(5): e61359 May 2013. \u00a0PMID:\u00a023650496<\/a>\u00a0 PMCID:\u00a0PMC3641071<\/a><\/li>\n
  14. Simin K, Hill R, Song Y, Zhang Q,\u00a0Bash R<\/b>, Cardiff RD, Yin C, Xiao A, McCarthy K, van Dyke T. \u00a0Deciphering cancer complexities in genetically engineered mice. \u00a0Cold Spring Harb Symp Quant Biol. \u00a070:283-290. \u00a02005. \u00a0PMID:\u00a016869764<\/a><\/li>\n
  15. Bash R<\/strong>, Matthysse AG. \u00a0Attachment of roots and virulence of a chvB mutant of Agrobacterium tumefaciens are temperature sensitive. \u00a0Mol Plant Microbe Interact. \u00a015(2):160-163. \u00a0Feb 2002. \u00a0PMID:\u00a011876426<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Research Specialist Department of Pathology and Laboratory Medicine 6105 Neurosciences Building 919-966-0587 ryan_bash [at] med.unc.edu     Education University of North Carolina School of Medicine Masters of Science (MS), June 2010 \u00a0Curriculum in Genetics and Molecular Biology University of North Carolina Bachelor of Science,\u00a0December 2000 Major:\u00a0\u00a0Biology Publications McNeill RS,\u00a0Stroobant EE,\u00a0Smithberger E,\u00a0Canoutas DA,\u00a0Butler MK,\u00a0Shelton AK,\u00a0Patel SD, … Read more<\/a><\/p>\n","protected":false},"author":68816,"featured_media":0,"parent":34,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-49","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/pages\/49","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/users\/68816"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/comments?post=49"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/pages\/49\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/pages\/34"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pathology\/millerlab\/wp-json\/wp\/v2\/media?parent=49"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}