{"id":5637,"date":"2020-10-06T10:53:46","date_gmt":"2020-10-06T14:53:46","guid":{"rendered":"https:\/\/www.med.unc.edu\/pathology\/?post_type=directory&p=5637"},"modified":"2025-10-16T16:09:52","modified_gmt":"2025-10-16T20:09:52","slug":"bronaus","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pathology\/directory\/bronaus\/","title":{"rendered":"Russell Broaddus, MD, PhD"},"content":{"rendered":"

Research Interests<\/h2>\n

My research lab focuses on the molecular pathogenesis of endometrial cancer, the most common gynecologic cancer in the Western world.\u00a0 Current projects include developing molecular diagnostics for predicting endometrial cancer histotype, stage, and recurrence developing clinical and lab-based algorithms for the identification of patients with hereditary endometrial cancer (Lynch Syndrome), discovering novel molecular mediators of endometrial cancer invasion and metastasis, and identifying novel signaling pathways important in the pathogenesis of endometrial cancer.<\/p>\n

Selected Publications<\/h2>\n

Bartley AN, Luthra R, Saraiya DS, Urbauer DL, Broaddus RR. Identification of cancer patients with Lynch syndrome: clinically significant discordances and problems in tissue-based mismatch repair testing. Cancer Prev Res (Phila) 2012; 5(2):320-7. PMCID:\u00a0PMC3273660<\/a><\/p>\n

Djordjevic B, Hennessy BT, Li J, Barkoh BA, Luthra R, Mills GB, Broaddus RR. Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing. Mod Pathol 2012; 25(5):699-708.\u00a0 PMCID:\u00a0PMC3341518<\/a>.<\/p>\n

Kurnit, K.C., Kim, G., Fellman, B.M., Urbauer, D., Mills, G.B., Zhang, W., Broaddus, R.R.\u00a0 CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.\u00a0 Mod Pathol 2017; 30:\u00a0 1032-1041.\u00a0 PMCID:\u00a0PMC5493522<\/a><\/p>\n

Bruegl AS, Djordjevic B, Batte B, Daniels MS, Fellman BM, Urbauer DL, Luthra R, Sun C, Lu K, Broaddus RR. Evaluation of clinical criteria for the identification of Lynch Syndrome among unselected endometrial cancer patients. Cancer Prev Res (Phila) 2014; 7:\u00a0 686-697.\u00a0 PMCID:\u00a0\u00a0PMC4090057<\/a><\/p>\n

Estrella JS, Ma LT, Milton DR, Yao JC, Wang H, Rashid A, Broaddus RR. Expression of estrogen-induced genes and estrogen receptor \u03b2 in pancreatic neuroendocrine tumors: implications for targeted therapy. Pancreas 2014; 43:\u00a0 996-1002.\u00a0 PMCID:\u00a0\u00a0PMC4628823<\/a><\/p>\n

Bowser JL, Blackburn MR, Shipley GL, Molina JG, Dunner K, Broaddus RR. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest 2016; 126(1): 220-38. PMCID:\u00a0PMC4701552<\/a><\/p>\n

Deng L, Feng J, Broaddus RR.\u00a0 The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.\u00a0 Cell Death Dis 2010; e32.\u00a0 PMCID:\u00a0\u00a0PMC2976047<\/a><\/p>\n

List of publications from\u00a0PubMed<\/a><\/strong><\/p>\n

\"Trained<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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