{"id":8485,"date":"2023-08-31T09:58:32","date_gmt":"2023-08-31T13:58:32","guid":{"rendered":"https:\/\/www.med.unc.edu\/pathology\/?post_type=directory&#038;p=8485"},"modified":"2025-10-17T09:36:08","modified_gmt":"2025-10-17T13:36:08","slug":"melinda-yates-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pathology\/directory\/melinda-yates-phd\/","title":{"rendered":"Melinda Yates, PhD"},"content":{"rendered":"<h5>Faculty Advisor, <a href=\"https:\/\/www.med.unc.edu\/pathology\/mcp\/mcp\/pbts\/womens-health-multidisciplinary-consortium\/\">Women&#8217;s Health Multidisciplinary Consortium<\/a><\/h5>\n<h2><span data-contrast=\"none\">About<\/span><\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-9171 alignright\" src=\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2023\/08\/MediumSquareLogo-whitebkgd86-e1739974476609-300x214.jpg\" alt=\"Trained mentor logo (white)\" width=\"252\" height=\"180\" srcset=\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2023\/08\/MediumSquareLogo-whitebkgd86-e1739974476609-300x214.jpg 300w, https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2023\/08\/MediumSquareLogo-whitebkgd86-e1739974476609-600x429.jpg 600w, https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2023\/08\/MediumSquareLogo-whitebkgd86-e1739974476609.jpg 690w\" sizes=\"auto, (max-width: 252px) 100vw, 252px\" \/><\/p>\n<p><span data-contrast=\"auto\">As a laboratory-based researcher, my experience and expertise are in translational tissue-based biomarker studies, molecular mech<\/span><span data-contrast=\"auto\">anisms of carcinogenesis, rodent models of cancer, and pharmacology. I have extensive experience in the characterization of molecular changes leading to development of endometrial cancer and biomarkers associated with treatment response and tumorigenesis in clinical studies. My program is centered in building bridges between laboratory-based research and unmet clinical needs, working in partnership with clinical colleagues.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<h2><span data-contrast=\"none\">Education\/Fellowships<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">BS in Chemistry, Purdue University<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">PhD in Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">Postdoctoral Fellowship, Cancer Prevention Research Training Program, Gynecologic Oncology, University of Texas MD Anderson Cancer Center<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<\/ul>\n<h2><span data-contrast=\"auto\">Expertise<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"none\">In parallel with human tissue-based studies, our team uses preclinical tools (rodent models, organoids, and novel cell lines) to understand mechanisms of endometrial cancer development.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Fun fact: I collaborate with a multidisciplinary team to develop and evaluate approaches to improve mentoring environments, so that faculty can implement data-driven approaches to improve research training.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<h2>Research Interests<\/h2>\n<ul>\n<li>Endometrial cancer<\/li>\n<li>Obesity-related cancer development<\/li>\n<li>Hereditary cancers (Lynch syndrome)<\/li>\n<li>Environmental exposures in cancer risk<\/li>\n<\/ul>\n<p><span class=\"TextRun SCXW196990601 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW196990601 BCX0\">The <\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW196990601 BCX0\">Yates<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> lab is focused on <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">cancers<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> that form in the lining of the uterus (endometrium). In contrast to <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">almost all<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> other <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">cancer types<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">, endometrial cancer incidence and mortality continue to increase at an alarming rate. To change these trends, our research has a particular emphasis on cancer interception (prevention). The <\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW196990601 BCX0\">Yates<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> lab is interested in the earliest <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">molecular changes that occur in the endometrium during cancer development related to obesity and hereditary DNA mismatch repair defects. <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">Our <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">overall<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> goal is to use these tools to define mechanisms related to <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">environmental factors (obesity, hormones, and exposures linked with social determinants of health) that influence endometrial cancer development and disparities.<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> Our research <\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">ultimately aims<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> to us<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\">e<\/span><span class=\"NormalTextRun SCXW196990601 BCX0\"> pharmacologic agents to prevent, block, or reverse endometrial cancer development and improve outcomes for women.<\/span><\/span><span class=\"EOP SCXW196990601 BCX0\" data-ccp-props=\"{&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<h2>Awards and Honors<\/h2>\n<p>President\u2019s Faculty Excellence Award in Cancer Prevention or Outreach, MD Anderson Cancer Center, 2022<\/p>\n<p>Faculty Recognition Award, University of Texas, MD Anderson, UTHealth Graduate School of Biomedical Sciences, 2022<\/p>\n<p>Faculty Educator of the Quarter, University of Texas, MD Anderson Cancer Center, 2020<\/p>\n<p>Faculty Recognition Award, University of Texas, MD Anderson, UTHealth Graduate School of Biomedical Sciences, 2019<\/p>\n<h2><span data-contrast=\"auto\">Current funding:<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">U54 CA302426 (NIH\/NCI)\u00a0\u00a0\u00a0\u00a0 <\/span> <span data-contrast=\"auto\">09\/04\/2025 \u2013 7\/31\/2030<\/span> <span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u201cObesity-related metabolic reprogramming in endometrial cancer disparities\u201d<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Role: Principal investigator (Project 3)<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Faculty Advisor, Women&#8217;s Health Multidisciplinary Consortium About As a laboratory-based researcher, my experience and expertise are in translational tissue-based biomarker studies, molecular mechanisms of carcinogenesis, rodent models of cancer, and pharmacology. I have extensive experience in the characterization of molecular changes leading to development of endometrial cancer and biomarkers associated with treatment response and tumorigenesis &hellip; <a href=\"https:\/\/www.med.unc.edu\/pathology\/directory\/melinda-yates-phd\/\" aria-label=\"Read more about Melinda Yates, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":8486,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-8485","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Melinda Yates, PhD | Department of Pathology and Laboratory Medicine<\/title>\n<meta name=\"description\" content=\"endometrial cancer, obesity, hereditary cancers, pharmacology, disparities, cancer prevention\" 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