{"id":9575,"date":"2025-10-08T09:50:56","date_gmt":"2025-10-08T13:50:56","guid":{"rendered":"https:\/\/www.med.unc.edu\/pathology\/?post_type=directory&p=9575"},"modified":"2025-10-09T12:45:52","modified_gmt":"2025-10-09T16:45:52","slug":"grant-fischer-md-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/","title":{"rendered":"Grant Fischer, MD, PhD"},"content":{"rendered":"

I am a physician-scientist trained in Anatomic Pathology, dermatopathology, and molecular genetic pathology. My doctoral research focused on improving our understanding of the features, drivers, and heterogeneity of melanoma brain metastases to improve our ability to treat this deadly disease complication. My current research utilizes a combination of bionformatics and wet lab techniques to improve our understanding of the molecular pathology of melanoma and other cutaneous neoplasms.<\/p>\n

SELECTED PUBLICATIONS:<\/p>\n

    \n
  1. \n
    Fischer<\/span> GM<\/b>, Maia-Silva D, Dias-Santagata D, Hornick JL, Russell-Goldman E. Undifferentiated melanoma: A clinicopathologic and gene expression analysis study with identification of HMGA2 as a diagnostic marker.\u00a0Am J Surg Pathol. 2025 Jul 9. doi: 10.1097\/PAS.0000000000002452. Epub ahead of print.<\/div>\n<\/li>\n
  2. \n
    Fischer<\/span> GM<\/b>, Lamba N, Vogelzang J, Aizer A, Ligon KL. Genomic profiling reveals SMARCA4<\/i>\u00a0mutations are associated with shorter overall and intracranial progression-free survival in melanoma brain metastasis patients. Clin Cancer Res. <\/i>2025;31(4):719-732.<\/div>\n<\/li>\n
  3. \n
    Fischer<\/span> GM<\/b>, Mahadevan NR, Hornick JL, Fletcher CDM, Russell-Goldman E. A comparative genomic study of conventional and undifferentiated melanoma. Mod Pathol. 2024;37(12):100626. doi: 10.1016\/j.modpat.2024.100626.<\/div>\n<\/li>\n
  4. \n
    Fischer<\/span> GM<\/b>, Gliem TJ, Greipp PT, Rosenberg AE, Folpe AL, Hornick JL. Anaplastic Kaposi sarcoma: A clinicopathologic and molecular genetic analysis. Mod Pathol. 2023;36(8):100191. Doi: 10.1016\/j.modpat.2023.100191.<\/div>\n<\/li>\n
  5. Fischer<\/span> GM<\/b>, Papke DJ. Gene fusions in superficial mesenchymal neoplasms: Emerging entities and useful diagnostic adjuncts. Semin Diagn Pathol. 2023;40(4):246-257.<\/li>\n
  6. \n
    Fischer<\/span> GM<\/b>, Lindeman NI, Ligon AH, Russell-Goldman E. Proliferating pilar tumors are characterized by recurrent 15q, 6q, and 6p22.2 alterations. Am J Dermatopathol. 2023;45(4):217-226.<\/div>\n<\/li>\n
  7. \n
    Fischer<\/span> GM<\/b>, Guerrieri RA, Hu Q, Joon AY, Kumar S, Haydu LE, McQuade JL, Vashisht Gopal YN, Knighton B, Deng W, Hudgens CW, Lazar AJ, Tetzlaff MT, Davies MA. Clinical, molecular, metabolic, and immune features associated with oxidative phosphorylation in melanoma brain metastases. Neurooncol Adv. 2021;3(1):vdaa177. doi: 10.1093\/noajnl\/vdaa177.<\/div>\n<\/li>\n
  8. \n
    Fischer<\/span> GM<\/b>, Carapeto FCL, Joon AY, Haydu LE, Chen H, Wang F, Van Arnam JS, McQuade JL, Wani K, Kirkwood JM, Thompson JF, Tetzlaff MT, Lazar AJ, Tawbi HA, Gershenwald JE, Scoyler RA, Long GV, Davies MA. Molecular and immunological associations of elevated serum lactate dehydrogenase in metastatic melanoma patients: A fresh look at an old biomarker. Cancer Med. 2020;9(22):8650-8661.<\/div>\n<\/li>\n
  9. \n
    Fischer<\/span> GM<\/b>, Jalali A, Kircher DA, Lee W, McQuade JL, Haydu LE, Joon A, Reuben A, Petaccia de Macedo M, Carapeto F, Yang C, Srivastava A, Ambati CR, Sreekumar A, Hudgens C, Knighton B, Deng W, Ferguson S, Tawbi HA, Glitza I, Gershenwald JE, Vashisht Gopal YN, Hwu P, Huse JT, Wargo JA, Futreal AP, Putluri N, Lazar AJ, DeBerardinis RJ, Marszalek JR, Zhang J, Holmen SL, Tetzlaff MT, Davies MA. Molecular profiling reveals unique immune and metabolic features of melanoma brain metastases. Cancer Discov.\u00a02019;9(5):628-645.<\/div>\n<\/li>\n
  10. Fischer<\/span> GM<\/b>, Yennu-Nanda VG, Peng W, McQuade JL, Davies MA. Metabolic strategies of melanoma cells: mechanisms, effects on the tumor microenvironment, and therapeutic implications. Pigment Cell Melanoma Res. <\/i>2018;31(1):11-30.<\/li>\n<\/ol>\n

    Pub Med Profile<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    I am a physician-scientist trained in Anatomic Pathology, dermatopathology, and molecular genetic pathology. My doctoral research focused on improving our understanding of the features, drivers, and heterogeneity of melanoma brain metastases to improve our ability to treat this deadly disease complication. My current research utilizes a combination of bionformatics and wet lab techniques to improve … Read more<\/a><\/p>\n","protected":false},"featured_media":9573,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_links_to":"","_links_to_target":""},"class_list":["post-9575","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"\nGrant Fischer, MD, PhD | Department of Pathology and Laboratory Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grant Fischer, MD, PhD | Department of Pathology and Laboratory Medicine\" \/>\n<meta property=\"og:description\" content=\"I am a physician-scientist trained in Anatomic Pathology, dermatopathology, and molecular genetic pathology. My doctoral research focused on improving our understanding of the features, drivers, and heterogeneity of melanoma brain metastases to improve our ability to treat this deadly disease complication. My current research utilizes a combination of bionformatics and wet lab techniques to improve … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Pathology and Laboratory Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-09T16:45:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2157\" \/>\n\t<meta property=\"og:image:height\" content=\"2518\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@UNCPathology\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/\",\"name\":\"Grant Fischer, MD, PhD | Department of Pathology and Laboratory Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg\",\"datePublished\":\"2025-10-08T13:50:56+00:00\",\"dateModified\":\"2025-10-09T16:45:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg\",\"width\":2157,\"height\":2518,\"caption\":\"Photo of Grant Fischer\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/pathology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Grant Fischer, MD, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/pathology\/\",\"name\":\"Department of Pathology and Laboratory Medicine\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/pathology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/#organization\",\"name\":\"UNC Department of Pathology and Laboratory Medicine\",\"url\":\"https:\/\/www.med.unc.edu\/pathology\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2017\/06\/PathologyandLaboratoryMedicine_logo_2c_rgb_v.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2017\/06\/PathologyandLaboratoryMedicine_logo_2c_rgb_v.png\",\"width\":488,\"height\":460,\"caption\":\"UNC Department of Pathology and Laboratory Medicine\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/pathology\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/UNCPathology\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Grant Fischer, MD, PhD | Department of Pathology and Laboratory Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/","og_locale":"en_US","og_type":"article","og_title":"Grant Fischer, MD, PhD | Department of Pathology and Laboratory Medicine","og_description":"I am a physician-scientist trained in Anatomic Pathology, dermatopathology, and molecular genetic pathology. My doctoral research focused on improving our understanding of the features, drivers, and heterogeneity of melanoma brain metastases to improve our ability to treat this deadly disease complication. My current research utilizes a combination of bionformatics and wet lab techniques to improve … Read more","og_url":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/","og_site_name":"Department of Pathology and Laboratory Medicine","article_modified_time":"2025-10-09T16:45:52+00:00","og_image":[{"width":2157,"height":2518,"url":"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@UNCPathology","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/","url":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/","name":"Grant Fischer, MD, PhD | Department of Pathology and Laboratory Medicine","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/pathology\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg","datePublished":"2025-10-08T13:50:56+00:00","dateModified":"2025-10-09T16:45:52+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg","contentUrl":"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2025\/10\/Fischer-Grant-photo.jpg","width":2157,"height":2518,"caption":"Photo of Grant Fischer"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/pathology\/directory\/grant-fischer-md-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/pathology\/"},{"@type":"ListItem","position":2,"name":"Grant Fischer, MD, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/pathology\/#website","url":"https:\/\/www.med.unc.edu\/pathology\/","name":"Department of Pathology and Laboratory Medicine","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/pathology\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/pathology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/pathology\/#organization","name":"UNC Department of Pathology and Laboratory Medicine","url":"https:\/\/www.med.unc.edu\/pathology\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/pathology\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2017\/06\/PathologyandLaboratoryMedicine_logo_2c_rgb_v.png","contentUrl":"https:\/\/www.med.unc.edu\/pathology\/wp-content\/uploads\/sites\/646\/2017\/06\/PathologyandLaboratoryMedicine_logo_2c_rgb_v.png","width":488,"height":460,"caption":"UNC Department of Pathology and Laboratory Medicine"},"image":{"@id":"https:\/\/www.med.unc.edu\/pathology\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/UNCPathology"]}]}},"_upd_display_name":["Grant Fischer, MD, PhD"],"_upd_reverse_display_name":["Fischer, Grant"],"_upd_last_name":["Fischer"],"_upd_first_name":["Grant"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["Assistant Professor\r\n\r\n<a href=\"mailto:Grant_Fisher@med.unc.edu\">Email<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/directory\/9575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":1,"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/directory\/9575\/revisions"}],"predecessor-version":[{"id":9576,"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/directory\/9575\/revisions\/9576"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/media\/9573"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pathology\/wp-json\/wp\/v2\/media?parent=9575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}