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Professor of Pediatrics

Education and Training

Medical School: Washington University

Internship & Residency: Massachusetts General Hospital

Fellowship: Harvard University
Area: Pediatric Health Services Research

Fellowship: Massachusetts General Hospital and Boston Children’s Hospital
Area: Pediatric Gastroenterology

Procedures and Research

Crohn’s disease; ulcerative colitis; pediatric endoscopy and colonoscopy; clinical epidemiology; and health services research.Cr+LfCr+LfMy research includes studies of the clinical and comparative effectiveness of treatments for Inflammatory Bowel Disease (IBD) using real-world data to evaluate the risks and benefits of treatments used in everyday clinical practice. He has received research funding from the National Institutes of Health (NIH), Agency for Healthcare Research and Quality (AHRQ), Patient-Centered Outcomes Research Institute (PCORI), foundations, and industry.Cr+LfCr+LfSelected examples of ongoing research studies include:Cr+LfCr+Lf- The largest pediatric Crohn’s trial in history to compare the effectiveness and safety of anti-TNF biologic agents (infliximab, adalimumab) used alone or in combination with a second immune suppressive agent (methotrexate).Cr+Lf- A patient powered research network for children and adults with IBD that utilizes internet based recruitment and data collection to study the course of IBD through the eyes of patients and caregivers.Cr+Lf- A study comparing the effectiveness and safety of 2nd line treatments for patients with IBD who did not respond to, or lost response to, anti-TNF.



Michael D. Kappelman, MD