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Program Mission

We are active members of the following consortiums offering clinical trials to patients with high-risk, relapsed and refractory malignancies: The mission of the Developmental Therapeutics and Pharmacology program is two-fold.

First, we seek to provide novel, safe, effective therapeutic options to children with high-risk, relapsed, and refractory malignancies. We are carrying out clinical, genomic, and biological research that will enhance care for future generations of children. We are utilizing a combination of UNC investigator-initiated, cooperative group, and pharmaceutical led trials to offer a range of options when precision medicine approaches are indicated, or when standard therapies have failed.

Second, we are utilizing the strengths of the UNC School of Pharmacy and the Lineberger Cancer Center to investigate dosing and toxicity of traditional agents, pharmacology of new molecules, and novel drug delivery mechanisms.


Program Leaders

Click here to email Drs. Alexander and Thompson to discuss trial eligibility or call 919-966-1178


Developmental Clinical Trials – UPDATES COMING SOON!


Recent Publications

For publications from Drs. Thompson or Alexander, please click here.