{"id":4615,"date":"2026-01-05T13:39:01","date_gmt":"2026-01-05T18:39:01","guid":{"rendered":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/?p=4615"},"modified":"2026-01-05T13:43:57","modified_gmt":"2026-01-05T18:43:57","slug":"4615","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/2026\/01\/4615\/","title":{"rendered":"Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI"},"content":{"rendered":"<figure id=\"attachment_4616\" class=\"thumbnail wp-caption alignleft\" style=\"width: 244px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4616\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM-234x300.png\" alt=\"Matthew Hirsch, PhD\" width=\"234\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM-234x300.png 234w, https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM.png 262w\" sizes=\"auto, (max-width: 234px) 100vw, 234px\" \/><figcaption class=\"caption wp-caption-text\">Matthew Hirsch, PhD<\/figcaption><\/figure>\n<p data-start=\"74\" data-end=\"515\">A recent publication by Matthew Hirsch, PhD, Associate Professor of Ophthalmology and Microbiology &amp; Immunology at UNC\u2019s Center for Molecular Medicine, advances UNC\u2019s MPS I corneal gene therapy work. The study demonstrates reversal of corneal clouding in an MPS VI feline model and, together with existing MPS I canine data, supports the therapy\u2019s safety and potential efficacy in humans.<\/p>\n<p data-start=\"517\" data-end=\"583\">\ud83d\udd17 Read the publication: <a class=\"decorated-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41348912\/\" target=\"_new\" rel=\"noopener\" data-start=\"542\" data-end=\"583\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41348912\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent publication by Matthew Hirsch, PhD, Associate Professor of Ophthalmology and Microbiology &amp; Immunology at UNC\u2019s Center for Molecular Medicine, advances UNC\u2019s MPS I corneal gene therapy work. The study demonstrates reversal of corneal clouding in an MPS VI feline model and, together with existing MPS I canine data, supports the therapy\u2019s safety and &hellip; <a href=\"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/2026\/01\/4615\/\" aria-label=\"Read more about Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI\">Read more<\/a><\/p>\n","protected":false},"author":119071,"featured_media":4616,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-4615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM.png","featured_image_medium":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM-234x300.png","featured_image_medium_large":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM.png","featured_image_large":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM.png","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-content\/uploads\/sites\/1312\/2026\/01\/Screenshot-2026-01-05-at-12.07.49-PM-150x150.png","featured_image_alt":"Matthew Hirsch, PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/posts\/4615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/users\/119071"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/comments?post=4615"}],"version-history":[{"count":6,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/posts\/4615\/revisions"}],"predecessor-version":[{"id":4622,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/posts\/4615\/revisions\/4622"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/media\/4616"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/media?parent=4615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/categories?post=4615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/pediatrics\/muenzer-mps-center\/wp-json\/wp\/v2\/tags?post=4615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}