{"id":27986,"date":"2021-04-13T17:01:07","date_gmt":"2021-04-13T21:01:07","guid":{"rendered":"https:\/\/www.med.unc.edu\/pediatrics\/?page_id=27986"},"modified":"2025-06-17T16:36:15","modified_gmt":"2025-06-17T20:36:15","slug":"developmental-therapeutics-and-pharmacology","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/developmental-therapeutics-and-pharmacology\/","title":{"rendered":"Developmental Therapeutics and Pharmacology"},"content":{"rendered":"<p><a name=\"top\"><\/a><\/p>\n<h2>Program Mission<\/h2>\n<p>We are active members of the following consortiums offering clinical trials to patients with high-risk, relapsed and refractory malignancies: The mission of the Developmental Therapeutics and Pharmacology program is two-fold.<\/p>\n<p>First, we seek to provide novel, safe, effective therapeutic options to children with high-risk, relapsed, and refractory malignancies. We are carrying out clinical, genomic, and biological research that will enhance care for future generations of children. We are utilizing a combination of UNC investigator-initiated, cooperative group, and pharmaceutical led trials to offer a range of options when precision medicine approaches are indicated, or when standard therapies have failed.<\/p>\n<p>Second, we are utilizing the strengths of the UNC School of Pharmacy and the Lineberger Cancer Center to investigate dosing and toxicity of traditional agents, pharmacology of new molecules, and novel drug delivery mechanisms.<\/p>\n<table style=\"height: 100%;width: 100%\" border=\"0\">\n<tbody>\n<tr>\n<th style=\"width: 25%\" width=\"25%\"><a href=\"https:\/\/childrensoncologygroup.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10371\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/cog-150x110-1.jpeg\" alt=\"\" width=\"170\" height=\"125\" \/><\/a><\/th>\n<th style=\"width: 25%\" width=\"25%\"><a class=\"external-link\" title=\"\" href=\"https:\/\/cbtn.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"image-inline aligncenter\" title=\"CBTN\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2023\/09\/HEMONC_LOGO_CBTN.png\" alt=\"CBTN\" width=\"166\" height=\"125\" \/><\/a><\/th>\n<th width=\"25%\"><a href=\"https:\/\/nationalpcf.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3872\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/sunshineproject-300x244-1.png\" alt=\"\" width=\"154\" height=\"125\" \/><\/a><\/th>\n<th style=\"width: 25%\" width=\"25%\"><a href=\"https:\/\/sarctrials.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3873\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/sarc-300x238-1.jpeg\" alt=\"\" width=\"157\" height=\"125\" \/><\/a><\/p>\n<div><\/div>\n<\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Program Leaders<\/h2>\n            <section>\n                <ul class=\"divisions-container multi-column\" aria-label=\"people-directory\">\n            <li class=\"row post entry\">\n    <div class=\"directory-gallery-thumbnail\">\n                                                                    \n                            <div class=\"entry-title\">\n                                    <a class=\"post-author\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/thomas-alexander-md-mph\/\">\n                                        <div class=\"upd-image\">\n                            <img loading=\"lazy\" decoding=\"async\" class=\"upd_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2020\/04\/DIR_HEMONC_Alexander-Thomas-768x1024.jpeg\" alt=\" \" height=\"160\" width=\"120\"\/>\n                            <img decoding=\"async\" class=\"print_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2020\/04\/DIR_HEMONC_Alexander-Thomas-768x1024.jpeg\" alt=\" \" \/>\n                        <\/div>\n                                                    Thomas Alexander, MD, MPH                                                            <\/a>\n                                <\/div>\n            \t\n            <\/div>\n\n    <div class=\"directory-gallery-content\">\n\n        \n\n        <div class=\"ud-gallery-view__positions\"><p class=\"ud-gallery-view__positions__title\">Associate Professor of Pediatrics<\/p>            <\/div>\n                \n                    \n<\/li><li class=\"row post entry\">\n    <div class=\"directory-gallery-thumbnail\">\n                                                                    \n                            <div class=\"entry-title\">\n                                    <a class=\"post-author\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/patrick-thompson-md\/\">\n                                        <div class=\"upd-image\">\n                            <img loading=\"lazy\" decoding=\"async\" class=\"upd_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2022\/03\/FIMG_HemOnc_Thompson-Patrick.png\" alt=\" \" height=\"160\" width=\"120\"\/>\n                            <img decoding=\"async\" class=\"print_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2022\/03\/FIMG_HemOnc_Thompson-Patrick.png\" alt=\" \" \/>\n                        <\/div>\n                                                    Patrick Thompson, MD                                                            <\/a>\n                                <\/div>\n            \t\n            <\/div>\n\n    <div class=\"directory-gallery-content\">\n\n        \n\n        <div class=\"ud-gallery-view__positions\"><p class=\"ud-gallery-view__positions__title\">Professor of Pediatrics<\/p><p class=\"ud-gallery-view__positions__title\">Fellowship Director of the Pediatric Hematology-Oncology Program<\/p>            <\/div>\n                \n                    \n<\/li>                <\/ul>\n            <\/section>\n                            <\/nav>\n\n            \n<p style=\"text-align: center\"><a class=\"btn btn-default btn-lg givebtn  oscitas-bootstrap-container\" target=\"_self\" href=\"mailto:talex@email.unc.edu; patom@email.unc.edu\">Click to email Drs. Alexander &amp; Thompson to discuss trial eligibility or call 919-966-1178<\/a>\n<p>&nbsp;<\/p>\n<h2>Developmental Clinical Trials &#8211; UPDATES COMING SOON!<\/h2>\n<p>&nbsp;<\/p>\n<h2>Recent Publications<\/h2>\n<p>For publications from Drs. Thompson or Alexander,<a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=(Thompson%2C%20Patrick%20A%5BAuthor%5D)%20OR%20Alexander%2C%20Thomas%20B%5BAuthor%5D\" target=\"_self\" rel=\"noopener noreferrer\">\u00a0please click here.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Program Mission We are active members of the following consortiums offering clinical trials to patients with high-risk, relapsed and refractory malignancies: The mission of the Developmental Therapeutics and Pharmacology program is two-fold. First, we seek to provide novel, safe, effective therapeutic options to children with high-risk, relapsed, and refractory malignancies. We are carrying out clinical, &hellip; <a href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/patrick-thompson-md\/\" aria-label=\"Read more about Patrick Thompson, MD\">Read more<\/a><\/p>\n","protected":false},"author":3424,"featured_media":0,"parent":27353,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-27986","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Developmental Therapeutics and Pharmacology | Department of Pediatrics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/developmental-therapeutics-and-pharmacology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Developmental Therapeutics and Pharmacology | Department of Pediatrics\" \/>\n<meta property=\"og:description\" content=\"Program Mission We are active members of the following consortiums offering clinical trials to patients with high-risk, relapsed and refractory malignancies: The mission of the Developmental Therapeutics and Pharmacology program is two-fold. 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