{"id":27990,"date":"2021-04-13T17:02:59","date_gmt":"2021-04-13T21:02:59","guid":{"rendered":"https:\/\/www.med.unc.edu\/pediatrics\/?page_id=27990"},"modified":"2024-10-11T17:12:37","modified_gmt":"2024-10-11T21:12:37","slug":"hematopoietic-stem-cell-transplant-research","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/hematopoietic-stem-cell-transplant-research\/","title":{"rendered":"Hematopoietic Stem Cell Transplant Research"},"content":{"rendered":"<p><a name=\"top\"><\/a><\/p>\n<h2>Program Mission<\/h2>\n<p>Dr. Kim Kasow&#8217;s research interests involve improving outcomes for a pediatric patient who require hematopoietic stem cell transplantation for the possibility of long-term survival. These patients include those requiring autologous and allogeneic stem cell transplants, regardless of the stem cell source.<\/p>\n<p>Our hematopoietic stem cell transplant research team participates in collaborative studies through the following consortiums: the <em><strong>Children&#8217;s Oncology Group (COG)<\/strong><\/em> , the <strong><em>Blood and Marrow Transplant Clinical Trials Network<\/em><\/strong>, and the <em><strong>Pediatric Blood and Marrow Transplant Consortium<\/strong><\/em> in order to help move the field of pediatric transplantation forward.<\/p>\n<p>We are active members of the following consortiums offering clinical trials to patients with high-risk, relapsed and refractory malignancies:<\/p>\n<table style=\"height: 100%;width: 100%\" border=\"0\">\n<tbody>\n<tr>\n<th style=\"width: 25%\" width=\"25%\"><a href=\"http:\/\/www.childrensoncologygroup.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10371\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/cog-150x110-1.jpeg\" alt=\"Children's Oncology Group\" width=\"170\" height=\"125\" \/><\/a><\/th>\n<th style=\"width: 25%\" width=\"25%\">\u00a0<a href=\"https:\/\/web.emmes.com\/study\/bmt2\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3878\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/blood-marrow-transplant-ctn-300x120-1.jpeg\" alt=\"\" width=\"313\" height=\"125\" \/><\/a><\/th>\n<th style=\"width: 25%\" width=\"25%\"><a href=\"http:\/\/www.pbmtc.org\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3879\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2021\/04\/pediatric-blood-and-marrow-transplant-consortium-1.png\" alt=\"\" width=\"409\" height=\"125\" \/><\/a><\/th>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Program Leaders<\/h2>\n            <section>\n                <ul class=\"divisions-container multi-column\" aria-label=\"people-directory\">\n            <li class=\"row post entry\">\n    <div class=\"directory-gallery-thumbnail\">\n                                                                    \n                            <div class=\"entry-title\">\n                                    <a class=\"post-author\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/george-hucks-jr-md\/\">\n                                        <div class=\"upd-image\">\n                            <img loading=\"lazy\" decoding=\"async\" class=\"upd_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2020\/09\/DIR_HEMONC_Hucks-John-768x1024.jpg\" alt=\" \" height=\"160\" width=\"120\"\/>\n                            <img decoding=\"async\" class=\"print_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2020\/09\/DIR_HEMONC_Hucks-John-768x1024.jpg\" alt=\" \" \/>\n                        <\/div>\n                                                    George Hucks, Jr., MD                                                            <\/a>\n                                <\/div>\n            \t\n            <\/div>\n\n    <div class=\"directory-gallery-content\">\n\n        \n\n        <div class=\"ud-gallery-view__positions\"><p class=\"ud-gallery-view__positions__title\">Assistant Professor of Pediatrics<\/p>            <\/div>\n                \n                    \n<\/li><li class=\"row post entry\">\n    <div class=\"directory-gallery-thumbnail\">\n                                                                    \n                            <div class=\"entry-title\">\n                                    <a class=\"post-author\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/michael-winstead-md\/\">\n                                        <div class=\"upd-image\">\n                            <img loading=\"lazy\" decoding=\"async\" class=\"upd_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2024\/02\/FIMG_HEMONC_Winstead-Michael.png\" alt=\" \" height=\"160\" width=\"120\"\/>\n                            <img decoding=\"async\" class=\"print_img\" src=\"https:\/\/www.med.unc.edu\/pediatrics\/wp-content\/uploads\/sites\/1115\/2024\/02\/FIMG_HEMONC_Winstead-Michael.png\" alt=\" \" \/>\n                        <\/div>\n                                                    Michael Winstead, MD                                                            <\/a>\n                                <\/div>\n            \t\n            <\/div>\n\n    <div class=\"directory-gallery-content\">\n\n        \n\n        <div class=\"ud-gallery-view__positions\"><p class=\"ud-gallery-view__positions__title\">Associate Professor of Pediatrics<\/p>            <\/div>\n                \n                    \n<\/li>                <\/ul>\n            <\/section>\n                            <\/nav>\n\n            \n<h2>Studies<\/h2>\n<h3>Currently Open Clinical Trails &#8211; UPDATES COMING SOON!<\/h3>\n<p><strong>If you have any questions about our clinical trails, please\u00a0<a class=\"email-link\" title=\"\" href=\"mailto:cuffee@med.unc.edu?subject=Transplant Research Inquiry\" target=\"_self\" rel=\"noopener noreferrer\">email the Transplant Coordinator, Juanita Cuffee<\/a>.<\/strong><\/p>\n<h2>Publications<\/h2>\n<p>Below is a list of recent publications; for additional publications from Dr. Kasow,\u00a0<a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Kasow%2C%20Kimberly%20A%5BAuthor%5D\" target=\"_self\" rel=\"noopener noreferrer\">please click here<\/a>.<\/p>\n<ol>\n<li><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27625358\" target=\"_self\" rel=\"noopener noreferrer\">A trail of unrelated onor marrow transplantation for children with severe sickle cell disease<\/a>. Shenoy, S., Eapen, M., Panepinto, J.A., Logan, B.R., Wu, J., Abraham, A., Brochstein, J., Chaudhury, S., Godder, K., Haight, A.E., Kasow, K.A., Leung, K., Andreansky, M., Bhatia, M., Dalal, J., Haines, H., Jaroscak, J., Lazarus, H.M., Levine, J.E., Krishnamurti, L., Margolis, D., Megason, G.C., Yu, L.C. Pulsipher, M.A., Gersten, I., DiFronzo, N., Horowitz, M.M., Walters, M.C., &amp; Kamani, N. \u00a0(2016).\u00a0<em>Blood.\u00a0<\/em><\/li>\n<li><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27164064\" target=\"_self\" rel=\"noopener noreferrer\">Long-term follow-up after reduced-intensity conditioning and stem cell transplantation for childhood nonmalignant disorders<\/a>. Madden, L.M., Hayashi, R.J., Chan, K.W., Pulsipher, M.A., Douglas, D., Hale, G.A., Chaudhury, S., Haut, P., Kasow, K.A., Gilman, A.L., Murray, L.M. &amp; Shenoy, S. (2016).\u00a0<em>Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation.<\/em><\/li>\n<li><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26481770\" target=\"_self\" rel=\"noopener noreferrer\">Sequential renal and bone marrow transplants in a child with Fanconi anemia<\/a>. Vincent, C.L., Primack, W.A., Hipps, J. &amp; Kasow, K.A.\u00a0<em>Pediatric Transplantation.\u00a0<\/em><\/li>\n<li><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25617808\" target=\"_self\" rel=\"noopener noreferrer\">Using fludarabine to reduce exposure to aklylating agents in children with sickle cell disease receiving busulfan, cyclophosphamide, and antithymocyte globulin transplant conditioning: Results of a dose de-escalation trail.<\/a> Horan, J.T., Haight, A., Dioguardi, J.L. Brown, C., Grizzle, A., Shelman, C., Kanter, J., Hale, G., Nieder, M., Benton, M, Kasow, K.A., Abraham, A. &amp; Chiang, K.Y. (2015).\u00a0<em>Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation.\u00a0<\/em><\/li>\n<li><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25579158\" target=\"_self\" rel=\"noopener noreferrer\">Through the eyes of young sibling donors: The hematopoietic stem cell donation experience.<\/a> D&#8217;Auria, J.P, Fitzgerald, T.M, Presler, C.M. &amp; Kasow, K.A. (2015).\u00a0<em>Journal of Pediatric Nursing.<\/em><\/li>\n<li><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25042734\" target=\"_self\" rel=\"noopener noreferrer\">Second solid cancers after allogeneic hematopoietic cell transplantation using reduced-intensity conditioning<\/a>. Ringden, O., Brazauskas, R., Wang, Z., Ahmed, I., Atsuta, Y., Buchbinder, D., Burns, L.J., Cahn, J.Y., Duncan, C., Hale, G.A., Halter, J., Hayashi, R.J., Hsu, J.W., Jacobsohn, D.A., Kamble, R.T., Kamani, N.R., Kasow, K.A., Khera, N., Lazarus, H.M., Loren, A.W., Marks, D.I., Myers, K.C., Ramanathan, M., Saber, W., Savani, B.N., Schouten, H.C., Socie, G., Sorror, M.L., Steinberg, A., Popat, U., Wingard, J.R., Mattsson, J. &amp; Majhail, N.S. (2014).\u00a0<em>Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation.<\/em><\/li>\n<\/ol>\n<p><a href=\"#top\">Return to Top<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Program Mission Dr. Kim Kasow&#8217;s research interests involve improving outcomes for a pediatric patient who require hematopoietic stem cell transplantation for the possibility of long-term survival. These patients include those requiring autologous and allogeneic stem cell transplants, regardless of the stem cell source. Our hematopoietic stem cell transplant research team participates in collaborative studies through &hellip; <a href=\"https:\/\/www.med.unc.edu\/pediatrics\/people\/michael-winstead-md\/\" aria-label=\"Read more about Michael Winstead, MD\">Read more<\/a><\/p>\n","protected":false},"author":3424,"featured_media":0,"parent":27353,"menu_order":13,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-27990","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hematopoietic Stem Cell Transplant Research | Department of Pediatrics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/pediatrics\/hemonc\/research\/hematopoietic-stem-cell-transplant-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hematopoietic Stem Cell Transplant Research | Department of Pediatrics\" \/>\n<meta property=\"og:description\" content=\"Program Mission Dr. Kim Kasow&#8217;s research interests involve improving outcomes for a pediatric patient who require hematopoietic stem cell transplantation for the possibility of long-term survival. These patients include those requiring autologous and allogeneic stem cell transplants, regardless of the stem cell source. 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