{"id":36237,"date":"2024-05-10T08:28:06","date_gmt":"2024-05-10T12:28:06","guid":{"rendered":"https:\/\/www.med.unc.edu\/pediatrics\/?post_type=ud_entry&p=36237"},"modified":"2025-06-10T14:29:22","modified_gmt":"2025-06-10T18:29:22","slug":"matthew-laughon-md-mph","status":"publish","type":"ud_entry","link":"https:\/\/www.med.unc.edu\/pediatrics\/people\/matthew-laughon-md-mph\/","title":{"rendered":"Matthew Laughon, MD, MPH"},"content":{"rendered":"

Dr. Laughon is a physician scientist specializing in Neonatal and Perinatal Medicine.<\/p>\n

Dr. Laughon\u2019s research interests include neonatal epidemiology, neonatal clinical pharmacology trials (phase I, II, and III), and neonatal lung disease-particularly bronchopulmonary dysplasia (BPD). His research work integrates clinical efforts of neonatologists and pharmacologists from academic healthcare institutions across the US to determine efficacy of medications in pediatric populations.<\/p>\n

Performing clinical trials in a neonatal population (infants up to 28 days of age) is challenging for many reasons, including 1) ongoing development of drug handling systems (i.e. liver and renal systems); 2) need for small volume and low number of samples; 3) low rates of parental consent; and 4) lack of pediatric clinical pharmacology expertise. Dr. Laughon\u2019s research team has successfully participated and led trials under the Food and Drug Administration\u2019s guidance to determine the optimal dose for off-patent therapeutics in term and premature infants. His team also works extensively with the Pediatric Trials Network and the Neonatal Research Network. Dr. Laughon is using innovative trial designs which have allowed him to successfully perform early phase trials in neonates in shorter times than traditional early phase studies. These innovations have been adopted by the pharmaceutical industry to study new drugs in development and to reduce timelines to approval.<\/p>\n

Dr. Laughon\u2019s future research plans include continuing investigation into medications used to treat common health problems associated with premature birth, including bronchopulmonary dysplasia, pulmonary arterial hypertension and patent ductus arteriosus.<\/p>\n

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