At the PGC, we have collaborators from around the world. Listed below are various career opportunities from some of our colleagues.
Biostatistician – Psychiatric genetics research program
We are looking for an experienced biostatistician to work on genome-wide data to understand the etiology of childhood mental illness in the multidisciplinary research team of Drs. Russell Schachar and Jennifer Crosbie. The successful applicant will work at the Hospital for Sick Children’s Research Institute on numerous collaborative projects with a focus on genome-wide association analyses (GWAS, polygenic risk scores, SNP heritability) and analysis of next-generation whole genome and exome sequence data. The research participant population comprises of a diverse mix of healthy children and children with childhood mental illnesses including attention-deficit/hyperactivity disorder, obsessive-compulsive disorder and autism spectrum disorder.
The successful candidate should have at least an MSc in biostatistics as well as experience with microarray and/or sequencing data. Experience relating to psychology, psychiatry or neuroscience data is an asset. Successful candidate should have experience in cleaning, manipulating and analyzing small and large datasets using shell (bash) scripts, R, plink, gcta, imputation tools and UNIX-based data manipulation software such as bcftools, vcftools, etc. This position will involve extensive data cleaning and statistical analysis of multifaceted datasets for the purposes of exploratory analysis, grant application and publication preparation. The successful candidate will also assist various trainees and study staff with statistical analysis and data interpretation as well as participate in international collaborations (e.g., Psychiatric Genomics Consortium). An ideal candidate would also have excellent problem-solving, time management and written and oral communication skills.
Employment Type: Full-Time Permanent, 1.0 FTE
Inquires about the position can be directed to Dr. Crosbie (firstname.lastname@example.org)
A joint bioinformatics post-doctoral position is available in the Neurobiology of Fear Laboratory, directed by Kerry Ressler, MD, PhD and the Translational Molecular Genomics Laboratory directed by Torsten Klengel MD, PhD.
The laboratory’s mission is to identify and understand molecular mechanisms of neuropsychiatric diseases and develop novel preventive and therapeutic approaches. The lab focuses on stress-related disorders and collaborates with other groups on the broad spectrum of neuropsychiatric disorders. We employ dry and wet lab genetic, epigenetic, transcriptomic and proteomic approaches together with sophisticated animal models for psychiatric disorders, postmortem brain, and clinical studies (www.klengellab.com and www.resslerlab.com).
To read more details, please see here.
The Statistical Genetics Data Analyst III will support our NIH-funded projects focused on the analysis of whole-genome, exome and genome-wide association (GWAS) data in psychiatric and neurodevelopmental disorders. The goal of our research is understand how the combined effects of rare genetic variation and common polygenic risk influence brain development and dimensional measures of cognitive function, and ultimately, how genes shape the clinical features of mental disorders.
Under the direction of Dr Jonathan Sebat, the Analyst will carry out statistical genetic analyses of large well-powered datasets from the Psychiatric Genomics Consortium, the Genes 2 Mental Health Network, the UK Biobank and the PsychEncode project. The Analyst will perform moderately to highly complex analysis of gene-trait relationships, functional characterization of genes, and will support multi-omics analysis of functional genomic data (RNA Sequencing, Ribosome profiling, Hi-C).
How To Apply: Candidates should send curriculum vitae and recommendations to Dr Jonathan Sebat. Please list subject line as: Applying for Statistical Genetics Data Analyst III.
Here is the link to our laboratory website: https://www.sebatlab.org
To read more details, please see here.
The Integrative Mental Health Lab (IMHL) at Stanford University is hiring 1-2 postdocs/analysts, to start work as early as September 2021. Our primary aim is to make discoveries using genomic data (GWAS and sequencing), and to translate those findings into improved treatments for psychiatric disorders. We seek motivated individuals, ideally with strong computational backgrounds (e.g. degree in mathematics, statistics, computer programing). Statistical genetics experience is preferred, but interested applicants are encouraged to apply regardless of past training experiences. Major projects in the lab include translational neuroscience projects designed to derive biological meaning from large-scale genomic findings, projects focused on hormone effects on mental health (leveraging genomic tools), and studies using data from postmortem tissue and single cell/nucleus assays. Trainee-led projects are also encouraged, and there are ample opportunities for growth in the lab and at Stanford. We have world class collaborations locally, nationally, and abroad to support a rich training experience. Please reach out if you have any questions. We look forward to meeting you!
Submit CV, a brief statement about scientific interests, and up to three writing samples to Dr. Laramie Duncan. Transcripts and other materials are optional. Please note that international students, minorities, women, and other protected individuals are particularly encouraged to apply.
Please see below an exciting postdoc statistical genetics job opportunity with Dr. Qingqin Li working on neuropsychiatric genetics. The position is dedicated to a Horizon 2020 funded REALMENT project under the leadership of Professor Ole Andreassen with 10+ consortium members from world leading institutes. Qingqin (email@example.com) would be happy to answer any questions you have. Link to the posted job https://jobs.jnj.com/jobs/2105941844W?lang=en-us&previousLocale=en-US.
We are excited to announce a new 4-year postdoc (funded by Horizon 2020, a funding mechanism in Europe) for result-oriented early career researcher with expertise in statistics genetics to work on GWAS, WES, and WGS data to conduct research in neuropsychiatric diseases and treatment response with a focus on schizophrenia, depression, and bipolar disorder (>=20K samples from neuropsychiatric diseases from Company Sponsored Clinical Studies (many of them are randomized controlled trials (RCT)) with rich/deep phenotype data and collaborative study studies. The postdoc will be dedicated to the Horizon 2020 project REALMENT with the main aim being to bring personalized medicine interventions to psychiatry across Europe. Building on Real-Word Data (RWD), the consortium will develop: i) a sustainable data infrastructure (REAL-WD platform) to facilitate access to RWD data across Europe; ii) novel artificial intelligence (AI) and machine learning (ML) tools to exploit large datasets/volumes of data; iii) a clinical management platform (4MENT) with algorithms for medication response and adverse effects to significantly improve patient outcomes and quality of life. Being the company with extensive RCT data participating in the consortium, REALMENT provides a unique opportunity to validate findings from RCTs (short term, monotherapy) in RWD (long term, polypharmacy) and vice versa. The postdoc will therefore be focusing on the genetic and clinical data generated from the RCT and collaborative studies but has the opportunity to interact with other consortium leaders from world leading institutes and laboratories. The postdoc will be a member of Neuroscience Data Science team in Janssen Research & Development, LLC (JRD) with presence in both United States and Europe and be exposed to other multi-omic/digital phenotyping/RWE projects and interacting with other organizations on drug discovery and drug development, and gain the first-hand experience on the clinical trial study design to meet the requirement of health authority in order to bring life-changing therapy to the patients with unmet medical needs.
The position will be based in Beerse, Belgium (considered as an employee of Janssen Pharmaceutica NV (JPNV), both JPNV and JRD are subsidiary of Johnson & Johnson). Other locations (especially locations where Johnson & Johnson has a presence such as Sweden Office (where KI close by is a participating REALMENT consortium member) could be considered on a case-by-case basis.
Link to the posted job: https://jobs.jnj.com/jobs/2105941844W?lang=en-us&previousLocale=en-US.
This is a full-time post and will be offered on a fixed-term contract for 48 months.
The laboratory of Sebastien Jacquemont is recruiting a talented postdoctoral researcher or PhD candidate to investigate genomic determinants of brain function and psychiatric disorders.
The laboratory of Sébastien Jacquemont is mapping the relationship between rare genomic variants, cognition, behaviour, and risk for neuropsychiatric conditions. This work will be conducted in close collaboration with the laboratories of Guillaume Dumas and Danilo Bzdok. G. Dumas is combining computational tools and multi-scale approaches for the study of mental function and dysfunction, and the tailoring of optimal care to the individual patient, from genomes to smartphones. The laboratory of D. Bzdok capitalizes on the largest emerging biomedical datasets to revisit classical questions in neuroscience by translating analytical tools from machine learning.
Requirements: The ideal candidate holds a solid background in genomics, bioinformatics, and data science and should have coding skills using either R, Python, or Matlab.
To read more details, please see here.
Here is the link to our laboratory website.
Here is the Research center website.
Autism genetics lab at University of California San Francisco seeking postdoctoral fellow or staff researcher for computational analysis of large datasets investigating gene-sex, gene-gene, and gene-environment interaction. Current funded projects include 1) investigating alternative models for explaining the genetic basis for sex differences in autism prevalence and 2) exploring the interplay of genetic predispositions, maternal health conditions, metabolic and immune biomarkers during pregnancy, and offspring neurodevelopmental outcomes. Background in human genetics and analytical experience in genome-wide datasets highly desirable; computer programming, advanced statistical skills, and experience in neuropsychiatric genetics also advantageous. The successful applicant will be self-motivated, a creative trouble-shooter, and flexible in contributing to a range of collaborative projects. Abundant opportunities to publish in the scientific literature, to use emerging technologies and methods, to collaborate with experimentalists, and to contribute to understanding the biological basis and therapeutic potential for autism and related disorders. Please send inquiries to Lauren.Weiss@ucsf.edu.
The PsycheMERGE Network is seeking postdoctoral fellows to work at Vanderbilt University Medical Center in the Davis, Ruderfer, or Walsh labs. We are seeking highly motivated individuals with knowledge of human genetics, informatics, or computational biology, and a strong sense of scientific curiosity, to join our community. In addition to these qualifications, the ideal candidates will have strong written and oral communication skills, excellent organizational skills, and a high level of personal integrity.
This is an exciting opportunity for someone who enjoys collaborative science, big data, analytic challenges, and human genomics. The ideal candidate will enjoy working in a fast-paced, intellectually exciting environment as an integral part of a highly motivated team of colleagues. Excellent communication, organizational skills, and friendly demeanor are essential. We are passionate about seeking a deeper understanding of psychiatry through genomics. If you meet the qualifications, are scientifically curious, and are eager for responsibility, we invite you to apply!
How to Apply: Please send a cover letter, CV, one recent publication, and a list of three references (name, institutional affiliation, email) to firstname.lastname@example.org with the subject line “VUMC PsycheMERGE postdoc application”.
To read more details, please see here.
We are seeking a highly skilled postdoctoral researcher in statistical/computational genomics. The postdoctoral researcher will join a collaborative team studying the genetic and epigenetic factors contributing to the development of, and outcomes associated with, attention-deficit/hyperactivity disorder (ADHD), mood dysregulation, and related traits in multiple longitudinal samples. Areas of focus will be the development and application of polygenic and polyepigenetic scores, evaluation of genetic correlation among psychiatric disorders/traits, investigation of mediators of genetic risk, and the interaction between genetic and environmental factors.
Work will be done in several large, publicly-available datasets (e.g., NIMH ABCD Study, Philadelphia Neurodevelopment Cohort, Psychiatric Genomics Consortium) as well as multiple growing, well-characterized, and deeply-phenotyped data sets at the Center for ADHD Research at Oregon Health & Science University in Portland, Oregon. Both established and novel methods will be applied to the analysis of genome-wide genotype and genome-wide DNA methylation data. Opportunity may also be available to examine neuroimaging data. The postdoctoral researcher on this project would be expected to conduct statistical and computational analyses and to lead manuscript preparation. Ample opportunity to lead and participate in publication will be available.
Requirements include a Ph.D. in Statistical Genetics, Computational Biology, Bioinformatics, Psychiatric Genetics, or other relevant field; excellent statistical and quantitative skills, and strong written and verbal communication skills. The ideal candidate will have experience with R and Python, and familiarity with genome-wide association analyses, epigenome-wide association analyses, polygenic risk scores, and other downstream analyses of genome-wide data.
Inquiries about this position can be directed to Dr. Mooney.
Start date any time September 2021-January 2022
We are looking for an enthusiastic postgraduate with a PhD in psychology, neuroscience, life sciences, genetics, epidemiology or a related subject. The successful applicant will work as a Postdoctoral Research Associate with Prof Thalia Eley in the Social, Genetic and Developmental Psychiatry (SGDP) Centre and will be a member of her Emotional Development, Intervention and Treatment (EDIT) Lab. The post is part of a 5-year MRC-funded project led by Prof Eley, focussed on understanding genetic and environmental influences on the development and intergenerational transmission of anxiety and depression.
The EDIT Lab strives to be a diverse research environment that is open, welcoming and supportive to all. Faculty-wide initiatives are supported by an active Diversity & Inclusion Team. The EDIT Lab is currently predominately women from white backgrounds. To ensure that we are the diverse team we strive to be, we particularly welcome applications from men and individuals from all any other race or ethnicity background (E.g. Black, Asian, Latinx). Please see the Group Culture tab for more information on this.
The post-holder will work with data from the Twins Early Development Study (TEDS), which has followed thousands of twin pairs since birth, tracking their emotional, cognitive and behavioural development. This summer we are launching a major mental health assessment as the twins reach their late twenties. We are also engaged in a challenging new effort linking the twins’ medical records to the information we already hold on them. You will lead analyses of the data resulting from these activities.
If successful, you will actively develop hypotheses, conduct genetic and genomic analyses and write up findings for publication. You will have the opportunity to attend relevant international meetings such as the Behavior Genetics Association and World Congress in Psychiatric Genetics.
The EDIT Lab members believe in Open and Reproducible Science. All papers are pre-registered on the Open Science Framework.
To apply/read more details see here.
Any questions, email Thalia on email@example.com
Deadline: August 31, 2021
The Kowalec Research Group invites applications for a postdoctoral position for a two-year term with the possibility of extension. Led by Dr. Kaarina Kowalec, the Kowalec research group is located within the Rady Faculty of Health Sciences at the University of Manitoba, Canada. This position is funded by the National Institutes of Mental Health (USA) for investigations of the role of genetic and environmental factors in severe psychiatric disorders, such as schizophrenia and depression. The position is based in Canada but works closely with collaborators from the University of North Carolina Chapel Hill (Prof Patrick Sullivan), Karolinska Institute (Dr. Lu Yi), University of Oslo (Prof Ole Andreassen), and Danish Institute of Biological Psychiatry (Prof Thomas Werge). Data will comprise of comprehensive national health register data from Sweden, as well as genome-wide SNP arrays, analysis of copy number variants (CNVs), and whole exome and whole genome sequencing. The position will commence on September 1, 2021, or on a date mutually agreed upon. Salary will be commensurate with experience and qualifications.
The Kowalec lab is a multi-disciplinary research program, which combines genomics and epidemiology to advance the outcomes of those affected by severe psychiatric disorders. Our work regularly involves an extensive network of International collaborators, including the Psychiatric Genomics Consortium. These recent papers describe our efforts in psychiatric genomics (PMID: 33550997, 33723211, 31712719, 31164630).
The overarching goals of the intended position are: on a population scale, how do genes and environment act and interact to modify risk for severe psychiatric disorders? By what molecular and cellular mechanisms do these genes act?
Review of candidates will start at the end of June and will continue until August 31, 2021. An application must contain the following in English:
- A complete resume, including date of the thesis defence, thesis title, previous academic positions, current position, academic distinctions, and committee work.
- Please also include a complete list of publications and a 1-page summary of current work.
You can find more information about required skills and how to apply here.
Deadline: June 1, 2021
The Department of Biomedicine at Faculty of Health at Aarhus University (AU), Denmark invites applications for an exciting position as Postdoc to do research in pharmacogenomics of ADHD as per 1st of September 2021, or as soon as possible thereafter. The position is a fixed-term fulltime position for two years.
About the research project
Stimulant medications are first line treatment for Attention Deficit Hyperactivity Disorder (ADHD) and have proven effective in reducing ADHD core symptoms and risk of several negative outcomes such as injuries, accidents and risk of substance use disorder. Despite this, ~50% of ADHD patients that initiate stimulants discontinue treatment within two years, with poor treatment response and side-effects being the most common reasons. The biological mechanisms underpinning medication discontinuation are not well understood, and the aim of this project is to identify common and rare genetic variants involved in ADHD medication discontinuation and elucidate the shared genetic architecture of medication discontinuation with cardiometabolic diseases. The project entails analyses of comprehensive genome-wide data generated by the iPSYCH consortium including more than 130,000 genotyped individuals (22K ADHD cases), which can be linked to information about ADHD medication use in the National Danish Prescription register.
The work is a part of the large EU-funded project TIMESPAN where the overall objective is to advance the management of cardiometabolic disease in patients with ADHD, by improving available treatments and risk stratification. The successful postdoc will work in a highly collaborative and interdisciplinary consortia setting together with leading researchers in psychiatry genetics and ADHD across Europe and the US. Specifically, the project will be conducted in close collaboration with researchers at the Department of Medical Epidemiology and Biostatistics (MEB) at Karolinska Institute (KI), Stockholm. The psychiatric genomics research group at Aarhus University and the psychiatric epidemiology group at KI have extensive experience with analysing Scandinavian register data, advanced pharmaco-epidemiology and psychiatric research experience, and will provide supervision in these areas to support the postdoc. Finally, there are possibilities to complete a research visits/stay at KI.
You can find more information about required skills and how to apply here.
We have an exciting position as researcher available at the Norwegian Institute of Public Health (NIPH) in Oslo funded through the Research Council of Norway on the project “Intergenerational Transmission of risk for common mental disorders” with a duration of 16 months with the possibility of extension. The successful applicant will work on novel data from more than 100,000 children and their parents from the Norwegian Mother and Child Cohort Study (MoBa), including genomic data, longitudinal questionnaire data from pregnancy onwards, and National registry data. The focus of the project is on the role of genetic and environmental risk factors in intergenerational transmission of risk for common mental disorders and personality traits. We will also examine associations between genetic risk factors and a number of environmental exposures, and the interplay between genetic and environmental risk factors.
The successful applicant will become part of an international and multidisciplinary research environment. The project is led by Professor Eivind Ystrøm and his research group at the Department of mental disorders at the NIPH in collaboration with PROMENTA research center at the University of Oslo, and King’s College London.
Please visit the application portal for more information.
Psychiatric genetics post doc position in Oslo funded by EU Marie Skłodowska-Curie Actions Grant, where applicant can participate in designing the project:
Please contact Ole Andreassen asap if interested.