Attention Deficit Hyperactivity Disorder
If you have questions concerning the projects this workgroup is undertaking, please contact the work group chair(s).
Data Intake Officer:
If you have questions about submitting samples to the PGC ADHD working group, please contact the data intake officer.
If you have questions concerning this web page or our social media accounts, and/or you have resources that you would like to share with the public, please contact the work group outreach liaison(s).
Data Access Committee (DAC) Representative:
If you have any questions about accessing PGC ADHD data, please contact the DAC representative.ADHD Data Access Portal
The ADHD workgroup was formed in 1998 with funding from a conference grant from the National Institute of Mental Health. We have been part of the PGC since its inception. During that time, our membership has grown to include 106 investigators from 29 institutions and 14 countries. Our group focuses on the study of ADHD and associated features in children and adults.
Our interdisciplinary membership includes graduate and postdoctoral trainees in psychiatric genetics as well as distinguished faculty in psychology, psychiatry, biostatistics, bioinformatics and genetics. Working together we have documented the existence of a polygenic background that mediates the risk for ADHD (please see Select Publications section below).
Our current goals are to:
- Increase the number of ADHD samples with genome-wide association data to 100,000
- Expand the diversity of ancestral populations in our samples
- Extend our work into exome/genome sequencing
Past and ongoing work of the ADHD group is at: https://sites.google.com/broadinstitute.org/pgcadhd/home?authuser=0.
If you are a member of the ADHD workgroup and have questions about a specific analysis or if you are interested in joining an ongoing project, please contact the investigator leading that project.
Cognition Working Group Chair
Focused on investigating the genomics of cognitive features associated with ADHD. Please contact the group chair if 1) you’re interested in joining the working group and have cognitive data on ADHD participants that can be shared with the PGC and/or 2) you have cognitive data on other neuropsychiatric conditions and would like to propose a collaboration.
Rovira P, Demontis D, Sánchez-Mora C, Zayats T, …ADHD Working Group of the Psychiatric Genomics Consortium; …Franke B, Ramos-Quiroga JA, Soler Artigas M, Ribasés M. (2020). Shared genetic background between children and adults with attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2020 Apr 12. https://doi.org/10.1038/s41386-020-0664-5
Demontis D., Walters, RK., Martin J., Mattheisen M., Als, TD., Esben Agerbo,… Benjamin M. Neale. (2019). Discovery Of The First Genome-Wide Significant Risk Loci For ADHD. Nature Genetics. http://doi.org/10.1038/s41588-018-0269-7
Martin J, Walters RK, Demontis D, Mattheisen M, Lee SH, Robinson E,… Neale BM. (2018). A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry. 83(12), 1044-1053. http://doi.org/10.1016/j.biopsych.2017.11.026