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Autism Spectrum Disorder

Workgroup Chairs:

The workgroup chairs of the ASD-PGC working group are Elise Robinson and Anders Børglum

Please contact them if you have any questions or remarks concerning the projects this workgroup is undertaking.

Outreach Liaison:

For questions or remarks concerning the ASD-PGC web page or our social media accounts, and/or you have interesting resources that you would like to share with the public, please contact the outreach liaison of the ASD-PGC working group Tinca Polderman..

About Us

ASD-PGC working group Anaheim WCPG 2019

 

The ASD-PGC working group was founded at the start of PGC, in 2008, and includes currently 48 investigators from 30 institutions, representing 10 countries.

For the coming years the ASD-PGC working group aims to:

  • Expand to include >100,000 ASD cases
  • Enhance ancestral diversity
  • Identify (much) more of the genetic risk variation, including the interplay between common and rare risk variation.
  • Improve understanding of genetic risk variants’ impact on pathophysiology
  • Dissect the heterogeneity of case subgroups
  • Enhance prediction of pertinent outcomes

 

Publications

Grove et al. Identification of common genetic risk variants for autism spectrum disorder. Nat Genet. 2019 Mar;51(3): 431-444.

Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.. Mol Autism. 2017 May 22;8:21.

Weiner et al. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet. 2017 Jul;49(7):978-985.

Cross-disorder group of the psychiatric genomics consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. 2019 Dec 12;179(7):1468-1482.

Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. 2018 Jun 22;360(6395).

Funders