Autism Spectrum Disorder
Please contact them if you have any questions or remarks concerning the projects this workgroup is undertaking.
For questions or remarks concerning the ASD-PGC web page or our social media accounts, and/or you have interesting resources that you would like to share with the public, please contact the outreach liaison of the ASD-PGC working group Tinca Polderman..
ASD-PGC working group Anaheim WCPG 2019
The ASD-PGC working group was founded at the start of PGC, in 2008, and includes currently 48 investigators from 30 institutions, representing 10 countries.
For the coming years the ASD-PGC working group aims to:
- Expand to include >100,000 ASD cases
- Enhance ancestral diversity
- Identify (much) more of the genetic risk variation, including the interplay between common and rare risk variation.
- Improve understanding of genetic risk variants’ impact on pathophysiology
- Dissect the heterogeneity of case subgroups
- Enhance prediction of pertinent outcomes
Grove et al. Identification of common genetic risk variants for autism spectrum disorder. Nat Genet. 2019 Mar;51(3): 431-444.
Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.. Mol Autism. 2017 May 22;8:21.
Weiner et al. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet. 2017 Jul;49(7):978-985.
Cross-disorder group of the psychiatric genomics consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. 2019 Dec 12;179(7):1468-1482.
Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. 2018 Jun 22;360(6395).